Name | Pteryxin |
Synonyms | Pterixin pteryxin Pteryxin Pteryxine (+)-Pteryxin |
CAS | 13161-75-6 |
EINECS | 2017-001-1 |
Molecular Formula | C21H22O7 |
Molar Mass | 386.4 |
Density | 1.28±0.1 g/cm3 (20 ºC 760 Torr) |
Melting Point | 81℃ |
Boling Point | 486.8±45.0 °C(Predicted) |
Specific Rotation(α) | (EtOH)+12.5 |
Solubility | Soluble in organic solvents such as methanol and acetone, insoluble in water. |
Appearance | Light yellow solid |
Storage Condition | 2-8℃ |
MDL | MFCD11519465 |
Physical and Chemical Properties | Soluble in methanol, ethanol, DMSO and other organic solvents, derived from Umbelliferae plant North American celery Pteryxia terebinthina(Hook.)Coulter root North American celery variety P.terebinthina var.terebinthina Coult.et Rose root Seseli ericephalum root dense flower rock phoenix Libanotis condensata (L.) Crantz(Seseli condensatum L.Reichb.) root Zizia aptera(Gray)Fernald root. |
biological activity | Pteryxin (( )-Pteryxin) is a dihydropyranocoumarin derivative found in the family Apiaceae Umbelliferae, it is also a potent inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 12.96 μg/ml. Pteryxin can inhibit the production of nitric oxide in mouse peritoneal macrophages induced by LPS with an IC50 value of 20 μm. Pteryxin has the potential to treat Alzheimer's disease (AD). |
Target | Value |
BChE (Cell-free assay) | 12.96 μM |
nitric oxide (in mouse peritoneal macrophages) | 20 μM |
Use | bevacizumab has the effects of lowering blood lipid, cholesterol, increasing coronary flow and lowering blood pressure. |