Pyridine-3-carboxanilide
nicotinanilide
CAS: 1752-96-1
Molecular Formula: C12H10N2O
Pyridine-3-carboxanilide - Names and Identifiers
| Name | nicotinanilide |
| Synonyms | NSC 108206 nicotinanilide NICOTINANILIDE LABOTEST-BB LT00114897 Pyridine-3-carboxanilide 3-PhenylaMinocarbonylpyridine N-phenylpyridine-3-carboxamide N-PHENYL-3-PYRIDINECARBOXAMIDE 3-(N-PHENYL-CARBOXAMIDO)-PYRIDINE Nicotinamide, (Pyridine-3-carboxanilide) |
| CAS | 1752-96-1 |
| EINECS | 217-138-4 |
| InChI | InChI=1/C12H10N2O/c15-12(10-5-4-8-13-9-10)14-11-6-2-1-3-7-11/h1-9H,(H,14,15) |
Pyridine-3-carboxanilide - Physico-chemical Properties
| Molecular Formula | C12H10N2O |
| Molar Mass | 198.22 |
| Density | 1.227±0.06 g/cm3(Predicted) |
| Melting Point | 114-118°C(lit.) |
| Boling Point | 265.8±13.0 °C(Predicted) |
| Flash Point | 114.5°C |
| Vapor Presure | 0.00898mmHg at 25°C |
| BRN | 142066 |
| pKa | 12.28±0.70(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Refractive Index | 1.65 |
| MDL | MFCD00023572 |
Pyridine-3-carboxanilide - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
Pyridine-3-carboxanilide - Introduction
nicotinanilide is an organic compound with the chemical formula C6H5N2C6H4COOH, also commonly known as niacin aniline. The following is a description of some of the properties, uses, formulation and safety information of nicotinanilide:
Nature:
1. Appearance: nicotinanilide is a white crystalline solid.
2. Solubility: nicotinanilide has low solubility in water, but it is soluble in organic solvents such as ethanol, methanol and acetic acid.
3. Stability: nicotinanilide is more stable under dry conditions, but it is easy to decompose under wet and heated conditions.
Use:
1. Drugs: nicotinanilide is a precursor compound of vitamin B3, which can be used to synthesize nicotinic acid (niacin) and nicotinamide (niacinamide), which exert important biological activities and pharmacological effects in the human body.
2. Cosmetics: nicotinanilide has moisturizing, whitening and anti-aging effects, and is often used in cosmetics as an active ingredient.
Method:
There are many ways to prepare nicotinanilide, among which the commonly used methods include the reaction of p-aminophenone and acetone nitrile. The specific step is heating and reacting aminophenone with acetone nitrile under the catalysis of sodium carbonate to obtain nicotinanilide.
Safety Information:
1. nicotinanilide has a stimulating effect on the skin and eyes, and should be rinsed with water immediately after contact.
2. During use and storage, avoid contact with strong oxidants and high heat sources to avoid fire or explosion.
3. Long-term or large-scale exposure may cause certain risks to human health. The dosage should be strictly controlled and relevant safety operation guidelines should be followed.
Nature:
1. Appearance: nicotinanilide is a white crystalline solid.
2. Solubility: nicotinanilide has low solubility in water, but it is soluble in organic solvents such as ethanol, methanol and acetic acid.
3. Stability: nicotinanilide is more stable under dry conditions, but it is easy to decompose under wet and heated conditions.
Use:
1. Drugs: nicotinanilide is a precursor compound of vitamin B3, which can be used to synthesize nicotinic acid (niacin) and nicotinamide (niacinamide), which exert important biological activities and pharmacological effects in the human body.
2. Cosmetics: nicotinanilide has moisturizing, whitening and anti-aging effects, and is often used in cosmetics as an active ingredient.
Method:
There are many ways to prepare nicotinanilide, among which the commonly used methods include the reaction of p-aminophenone and acetone nitrile. The specific step is heating and reacting aminophenone with acetone nitrile under the catalysis of sodium carbonate to obtain nicotinanilide.
Safety Information:
1. nicotinanilide has a stimulating effect on the skin and eyes, and should be rinsed with water immediately after contact.
2. During use and storage, avoid contact with strong oxidants and high heat sources to avoid fire or explosion.
3. Long-term or large-scale exposure may cause certain risks to human health. The dosage should be strictly controlled and relevant safety operation guidelines should be followed.
Last Update：2024-04-09 02:00:43
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