R-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol

Name	2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol
Synonyms	PNU-200577 PNU 200577 Desfesoterodine (R)-5-HydroxyMethyl Tolterodine (R)-5-Hydroxymethyl tolterodine 5-hydroxyMethyl tolterodine (PNU 200577) R-(+)-2(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol R-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol 2-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]-4-(hydroxymethyl)phenol (R)-2-(3-(diisopropylaMino)-1-phenylpropyl)-4-(hydroxyMethyl)phenol (5-HMT) 3-[(1R)-3-[Bis(1-methylethyl)amino]-1-phenylpropyl]-4-hydroxybenzenemethanol 3-[(1R)-3-[Bis(1-Methylethyl)Amino]-1-Phenylpropyl]-4-Hydroxy-Benzenemethanol
CAS	207679-81-0
InChI	InChI=1/C22H31NO2/c1-16(2)23(17(3)4)13-12-20(19-8-6-5-7-9-19)21-14-18(15-24)10-11-22(21)25/h5-11,14,16-17,20,24-25H,12-13,15H2,1-4H3/t20-/m1/s1

Molecular Formula	C22H31NO2
Molar Mass	341.49
Density	1.060±0.06 g/cm3(Predicted)
Melting Point	68-72°C
Boling Point	490.7±45.0 °C(Predicted)
Flash Point	233.165°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0mmHg at 25°C
Appearance	Solid
Color	Off-White to Pale Yellow
pKa	9.61±0.48(Predicted)
Storage Condition	-20°C Freezer
Refractive Index	1.563
In vitro study	5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine competitively inhibits carbacol-induced contraction of isolated guinea pig bladder strips with concentration-dependent characteristics. 5-hydroxymethyl tolterodine antagonized the muscarinic receptor with a pA 2 value of 9.1. 5-hydroxymethyl tolterodine can inhibit (-) 5-hydroxymethyl tolterodine in guinea pig bladder, parotid gland, heart and cerebral cortex homogenates with pharmacological properties similar to that of tolterodine. Intravenous injection of 5-hydroxymethyl tolterodine inhibits bladder volume-induced bladder contraction, which is representative of micturition pressure, in a dose-dependent manner.
In vivo study	5-hydroxymethyl tolterodine inhibited acetylcholine-induced bladder contraction in anesthetized cats more effectively than electrical stimulation-induced salivation with ID50 of 15 and 40 nmol/kg, respectively. 5-hydroxymethyl tolterodine is three times more effective in the bladder than in the salivary glands.

Last Update：2024-01-02 23:10:35

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R-(+)-2-(3-diisopropylamino-1-phenylpropyl)-4-hydroxymethylphenol Request for Quotation