R162
R162
CAS: 64302-87-0
Molecular Formula: C17H12O3
R162 - Names and Identifiers
| Name | R162 |
| Synonyms | R162 R 162 R-162 2-Allyl-1-hydroxy-9,10-anthraquinone 9,10-Anthracenedione, 1-hydroxy-2-(2-propen-1-yl)- |
| CAS | 64302-87-0 |
R162 - Physico-chemical Properties
| Molecular Formula | C17H12O3 |
| Molar Mass | 264.28 |
| Density | 1.308±0.06 g/cm3(Predicted) |
| Melting Point | 120-120.5 °C(Solv: acetone (67-64-1)) |
| Boling Point | 459.0±34.0 °C(Predicted) |
| Solubility | DMSO: ≥ 100 mg/mL |
| Appearance | solid |
| Color | Orange |
| pKa | 7.43±0.20(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
| In vitro study | Inhibition of GDH1 activity by R162 treatment results in decreased intracellular fumarate levels, attenuated GPx activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells, which can be significantly rescued by methyl-α-KG treatment as well as by antioxidant NAC. R162 inhibits cell proliferation and tumor growth potential of human cancer cells. |
| In vivo study | R162 (30 mg/kg/day, i.p.) does not result in a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties in xenograft tumor mouse models. R162 (20 mg/kg/day) results in significantly decreased tumor growth and masses in mice compared with control mice and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice. |
R162 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.784 ml | 18.92 ml | 37.839 ml |
| 5 mM | 0.757 ml | 3.784 ml | 7.568 ml |
| 10 mM | 0.378 ml | 1.892 ml | 3.784 ml |
| 5 mM | 0.076 ml | 0.378 ml | 0.757 ml |
Last Update：2024-01-02 23:10:35
R162 - Introduction
R162 refers to the compound benzoic acid (also known as benzoic acid). The following is a description of its nature, use, preparation and safety information:
Nature:
R162 is a colorless crystal with aromatic and sour taste. Its chemical formula is C6H5CH2COOH and its molar mass is 122.12g/mol. It is solid at room temperature, soluble in water and organic solvents.
Use:
R162 has a wide range of uses in the chemical industry. It is often used as a solvent, preservative and mordant. In addition, it can also be used in the synthesis of flavors, drugs and dyes.
Preparation Method:
R162 can be prepared by the oxidation of phenyl ethylene and benzophenone peroxide under the catalysis of a reactant. The specific preparation method can be adjusted according to actual needs to adapt to different synthesis conditions and reaction requirements.
Safety Information:
R162 is generally safe under normal conditions of use. However, it is a corrosive substance that can cause damage to the skin, eyes and respiratory system. Therefore, wear appropriate protective equipment such as gloves, goggles and respiratory protection when handling r162. In addition, care should be taken to avoid contact with strong oxidants and combustibles to prevent dangerous accidents. When using and storing R162, Please strictly follow the relevant safety operation procedures. If an accident occurs, seek medical help immediately.
Nature:
R162 is a colorless crystal with aromatic and sour taste. Its chemical formula is C6H5CH2COOH and its molar mass is 122.12g/mol. It is solid at room temperature, soluble in water and organic solvents.
Use:
R162 has a wide range of uses in the chemical industry. It is often used as a solvent, preservative and mordant. In addition, it can also be used in the synthesis of flavors, drugs and dyes.
Preparation Method:
R162 can be prepared by the oxidation of phenyl ethylene and benzophenone peroxide under the catalysis of a reactant. The specific preparation method can be adjusted according to actual needs to adapt to different synthesis conditions and reaction requirements.
Safety Information:
R162 is generally safe under normal conditions of use. However, it is a corrosive substance that can cause damage to the skin, eyes and respiratory system. Therefore, wear appropriate protective equipment such as gloves, goggles and respiratory protection when handling r162. In addition, care should be taken to avoid contact with strong oxidants and combustibles to prevent dangerous accidents. When using and storing R162, Please strictly follow the relevant safety operation procedures. If an accident occurs, seek medical help immediately.
Last Update：2024-04-09 20:52:54
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Product Name: R162 Visit Supplier Webpage Request for quotationCAS: 64302-87-0
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: R162 Visit Supplier Webpage Request for quotationCAS: 64302-87-0
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: R162 Visit Supplier Webpage Request for quotationCAS: 64302-87-0
Tel: +16314854226
Email: info@bocsci.com
Mobile: +16314854226
Linkedin: https://www.linkedin.com/company/boc-sciences
Product List: View Catalog
Spot supply
Product Name: R162 Visit Supplier Webpage Request for quotationCAS: 64302-87-0
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: R162 Visit Supplier Webpage Request for quotationCAS: 64302-87-0
Tel: 18301782025
Email: 3008007409@qq.com
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View History
R162
2-methoxy-p-phenylenediaminesulfate
Anion exchange resin 717
1040274-10-9
2-thioxo-3-[4-(trifluoromethyl)phenyl]thiazolidin-4-one
amyloid protein non-aβ component
儿茶提取物
cobalt(2+),ditetrafluoroborate,hexahydrate
380659-06-3
(3aR,4S,7aR)-Octahydro-4-hydroxy-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester
2-methoxy-p-phenylenediaminesulfate
Anion exchange resin 717
1040274-10-9
2-thioxo-3-[4-(trifluoromethyl)phenyl]thiazolidin-4-one
amyloid protein non-aβ component
儿茶提取物
cobalt(2+),ditetrafluoroborate,hexahydrate
380659-06-3
(3aR,4S,7aR)-Octahydro-4-hydroxy-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester