RAD51 inhibitor 1

Name	RI-1
Synonyms	RI1 RI-1 RAD51 inhibitor 1 RAD51 inhibitor RI-1 3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-
CAS	415713-60-9

Molecular Formula	C14H11Cl3N2O3
Molar Mass	361.61
Density	1.61
Boling Point	483.0±45.0 °C(Predicted)
Solubility	DMSO 50 mg/mL;Water <1 mg/mL; EtOH <1 mg/mL
Appearance	powder
Color	yellow to orange
pKa	-3.45±0.20(Predicted)
Storage Condition	2-8°C
Stability	Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Use	The RI-1 is a RAD51 inhibitor with an IC50 of 5 to 30 μM.
In vitro study	RI-1 by direct and specific destruction of HsRAD51 and inhibition of RAD51, the ability to form single-stranded DNA filaments, increase the sensitivity of cells to DNA damage. In addition, MCF-7 of all three cancer cell lines (HeLa cells, RI-1 and U2OS) produced single-dose toxicity alone with LD50 values in the 20-40 micron range. RI-1 reduced γ-H2AX foci in G2 cells and resulted in an increase in unrepaired DNA double-strand breaks 6 hours after irradiation.
In vivo study	RI-1 (50 mg/kg; i.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumor growth in mice. Animal Model: Female BALB/c nude mice (6 weeks) bearing TNBC tumor Dosage: 50 mg/kg Administration: I.p. every 3 days for 30 days Result: Resulted in significant inhibition of tumor growth. Did not cause body weight loss significantly.

Last Update：2024-01-02 23:10:35

Biological activity	RI-1 (RAD51 inhibitor 1) is a RAD51 inhibitor with an IC50 of 5 to 30 µM.
target	TargetValue RAD51 <30 μM
Target	Value
RAD51	<30 μM
in vitro study	RI-1 the ability to form single-stranded DNA filaments and improve the sensitivity of cells to DNA damage by directly and specifically destroying HsRAD51 and inhibiting RAD51. In addition, in all three cancer cell lines (HeLa cells, MCF-7 and U2OS), RI-1 single-dose toxicity alone, LD50 values are in the 20-40 micrometer range. RI-1 reduced γ-H2AX foci in G2 phase cells and resulted in an increase in unrepaired DNA double-strand breaks after 6 h of irradiation.
in vivo study	RI-1 (50 mg/kg; I.p. every 3 d for 30 d) significantly reduces triple negative breast cancer (TNBC) tumour growth in mice. Animal model: female balb/c nude mice (6 weeks) bearing TNBC tumour Dosage: 50 mg/kg Administration: I.p. every 3 days for 30 days result: Resulted in significant inhibition of tumor growth. did not cause body weight loss significantly.
Animal Model:	Female BALB/c nude mice (6 weeks) bearing TNBC tumor
Dosage:	50 mg/kg
Administration:	I.p. every 3 days for 30 days
Result:	Resulted in significant inhibition of tumor growth. Did not cause body weight loss significantly.

Last Update：2024-04-09 22:09:11

Product Name: RI-1 Visit Supplier Webpage Request for quotation
CAS: 415713-60-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: RI-1 Visit Supplier Webpage Request for quotation
CAS: 415713-60-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

RAD51 inhibitor 1

RAD51 inhibitor 1 Request for Quotation