RESERPINE(RG)
Reserpine
CAS: 50-55-5
Molecular Formula: C33H40N2O9
RESERPINE(RG) - Names and Identifiers
RESERPINE(RG) - Physico-chemical Properties
| Molecular Formula | C33H40N2O9 |
| Molar Mass | 608.69 |
| Density | 1.2336 (rough estimate) |
| Melting Point | ~265 °C (dec.) |
| Boling Point | 655.12°C (rough estimate) |
| Specific Rotation(α) | D23 -118° (CHCl3); D26 -164° (c = 0.96 in pyridine); D26 -168° (c = 0.624 in DMF) |
| Flash Point | 22℃ |
| Water Solubility | Soluble in water. |
| Solubility | Easily soluble in chloroform, dichloromethane, glacial acetic acid, soluble in benzene, ethyl acetate, slightly soluble in acetone, methanol, ethanol, ether, acetic acid and citric acid dilute aqueous solution, insoluble in water. |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White or light yellowish brown crystalline powder |
| Color | Off-white |
| Merck | 14,8145 |
| BRN | 102014 |
| pKa | 6.6(at 25℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents. |
| Refractive Index | 177 ° (C=1, DMF) |
| MDL | MFCD00005091 |
| Physical and Chemical Properties | White or pale yellow-brown crystalline powder. Melting point 264-265 °c (decomposition). Soluble in chloroform (about 1g/6ml), slightly soluble in acetone, ethanol (1g/1800ml), insoluble in water. No odor, almost tasteless, light color gradient deep. |
| Use | Widely used in the treatment of mild and moderate hypertension |
RESERPINE(RG) - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R67 - Vapors may cause drowsiness and dizziness R36 - Irritating to the eyes R10 - Flammable |
| Safety Description | S22 - Do not breathe dust. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| UN IDs | 3077 |
| WGK Germany | 3 |
| RTECS | ZG0350000 |
| FLUKA BRAND F CODES | 10-23 |
| TSCA | Yes |
| HS Code | 29399990 |
| Packing Group | II |
| Toxicity | LD50 oral in rat: 420mg/kg |
RESERPINE(RG) - Reference
| Reference Show more | 1. Liang Xuedan, Lin Chuanquan, Zeng Xinping, et al. Study on spleen-qi deficiency rat model induced by reserpine based on semi-quantitative evaluation of physical signs [J]. New Traditional Chinese Medicine & Clinical Pharmacology, 2019, 30(01):26-32. 2. Liu Shuang, Zhang Xiaofei, Miao Xin, Xing Haiyan, Li Gang. Study on the compatibility ratio of Mongolian medicine "Terminalia chebulae solution Aconitum" [J]. China Pharmacy, 2019, 30(11):1519-1524. 3. Jiang Chunyu, Xie Lu, Song Lingling. Effects of donkey milk on some physiological indexes of mice with spleen deficiency syndrome [J]. Journal of Animal and feed Sciences, 2017,38(07):18-19. 4. Sun Lei, Li Zhao, Wu huaixiu, etc. Preparation of recombinant human acetylcholinesterase expression in vitro and screening of related small molecule activity [J]. Journal of Pharmaceutical Analysis, 2019(3):386-392. 5. Lili, Chen Yong, Zhang Mengwei, Huang Hongxia, Gao Shouhong, Chen Wansheng. Determination of 11 main components in UHPLC-MS experience prescription cold dampness lung decoction by Novel coronavirus pneumonia (COVID-19)/MS [J]. Journal of Pharmaceutical Practice, 2021,39(02):148-151 156. 6. Yang, Hui, et al. "Essential abuse mechanism of araloside A in situ single-pass essential perfusion and in vitro Caco-2 cell model." Biomedicine & Pharmacotherapy 106 (2018): 1563-1569.https://doi.org/10.1016/j.biopha.2018.07.117 7. Zhenlong Qin, Lei Wang, Guoyan Li, Xuwen Qian, Jie Zhang, Ying Guo, Guokai Liu,Analysis of the analgesic effects of tricyclic antidepressants on neuropathic pain, diabetic neuropathic pain, and fibromyalgia in rat models,Saudi Journal of Biological Scien 8. [IF=4.545] Hui Yang et al."Intestinal absorption mechanisms of araloside A in situ single-pass intestinal perfusion and in vitro Caco-2 cell model."Biomed Pharmacother. 2018 Oct;106:1563 9. [IF=3.411] Zhi Meiru et al."Influence of Different Dosage Forms on Pharmacokinetics of 6 Alkaloids in Raw Aconiti Kusnezoffii Radix (Caowu) and Chebulae Fructus- (Hezi-) Processed Caowu by UPLC-MS/MS."Biomed Res Int. 2020;2020:1942849 |
RESERPINE(RG) - Standard
Authoritative Data Verified Data
This product is 18B-(3,4, 5-trimethoxybenzoyloxy)-11, 17a-dimethoxy-3b, 20a-hexamethyl-16b-methyl formate. Calculated as the dried product, the content of C33H40N209 shall not be less than 98.5%.
Last Update：2024-01-02 23:10:35
RESERPINE(RG) - Trait
Authoritative Data Verified Data
- This product is white to light yellow-brown crystal or crystalline powder; Odorless, light color gradient deep.
- This product is soluble in chloroform, slightly soluble in acetone, and almost insoluble in water, methanol, ethanol or ether.
specific rotation
take this product, precision weighing, plus three gas methane dissolution and quantitative dilution of each lml containing about 10 mg of the solution, according to the law (General 0621), the specific rotation was from 115 ° to -131 °.
Last Update：2022-01-01 11:57:46
RESERPINE(RG) - Differential diagnosis
Authoritative Data Verified Data
- take about 1 mg of this product and add 0.1% of sulfuric acid solution of 0.3 sodium molybdate, which shows yellow color and turns blue after about 5 minutes.
- take about 1 mg of this product and add 0.2 of the new vanillin test solution. After about 2 minutes, it will appear Rose Red.
- take about 0.5mg of this product, add 5mg of p-dimethylaminobenzaldehyde, 0.2ml of glacial acetic acid and 0.2 of sulfuric acid, mix well to show green; Add 1ml of glacial acetic acid to turn red.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 195).
Last Update：2022-01-01 11:57:47
RESERPINE(RG) - Exam
Authoritative Data Verified Data
oxidation products
Take 20mg of this product, put it in a measuring flask, add glacial acetic acid to dissolve and dilute to the scale, shake well, according to UV-visible spectrophotometry (General rule 0401), the absorbance was measured at a wavelength of 388mn, not exceeding 0.10.
Related substances
operation in the dark. Take about 10mg of this product, put it in a 10ml measuring flask, add 1 ml of glacial acetic acid to dissolve it, dilute it to the scale with methanol, shake it well, and use it as a test solution, set in a 100ml measuring flask, dilute to the scale with the mobile phase, and shake to serve as a control solution. According to the chromatographic conditions under the content determination item, each lol of the test solution and the control solution is accurately measured and injected into the human liquid chromatograph respectively, and the chromatogram is recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be greater than 1.5 times (1.5%) of the main peak area of the control solution.
loss on drying
take this product, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.15% (General rule 0841).
Last Update：2022-01-01 11:57:48
RESERPINE(RG) - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
chromatographic conditions and system suitability test
silica gel bonded with eighteen alkyl silane was used as the filler; Acetonitrile -1% ammonium acetate solution (46:54) was used as the mobile phase; The detection wavelength was 268nm. The number of theoretical plates shall not be less than 4000 calculated by reserpine peak; The separation degree between reserpine peak and adjacent impurity peaks shall meet the requirements.
assay
operation in the dark. Take about 50mg of this product, put it in a lOOml measuring flask, add 3ml of glacial acetic acid to dissolve it, dilute it with methanol to the scale, shake it, and take an appropriate amount with precision, A solution containing about 40ug per lml was prepared by quantitative dilution with methanol, and 20M1 was injected into the liquid chromatograph to record the chromatogram. Another reference substance of reserpine was used for precision weighing and determination by the same method. According to the external standard method to calculate the peak area, that is.
Last Update：2022-01-01 11:57:49
RESERPINE(RG) - Category
Authoritative Data Verified Data
antihypertensive drugs.
Last Update：2022-01-01 11:57:49
RESERPINE(RG) - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:57:49
RESERPINE(RG) - Reserpine Tablets
Authoritative Data Verified Data
This product contains reserpine (C33H40N209) should be labeled the amount of 90.0% ~ 110.0%.
trait
This product is colored or sugar-coated tablets. Removal of the coating showed a white or yellowish brown color.
identification
take an appropriate amount of fine powder of this product (about 2.5mg equivalent to reserpine), extract with 10ml of chloroform, filter, evaporate the filtrate, and identify the residue according to reserpine item (1), (2) (3) the test showed the same reaction.
examination
- Content uniformity protected from light. Take 1 tablet of this product, put it in a 50ml Brown measuring flask, heat 5ml of water, fully shake to disintegrate, add 5ml of chloroform, shake, dilute with ethanol to the scale, according to the preparation of the test solution under the content determination item, the content shall be measured and calculated according to law from the "shake, filter", and the content shall be in accordance with the regulations (General 0941).
- dissolution of this product, according to the dissolution and release determination method (General 0931 second method), with 0.100 ml of 1 mol/L acetic acid solution is the dissolution medium, the rotation speed is 0.8 rpm, and the operation is carried out according to law. After 30 minutes, take about 25ml of the solution and filter it with a filter membrane (the pore size is less than um), 10ml of the primary filtrate was discarded, and the secondary filtrate was taken as a test solution. Another reserpine reference material 25mg, precision weighing, plus chloroform 1 ml and anhydrous ethanol 80ml dissolved in 0.1 mol/L acetic acid solution was diluted to a solution containing reserpine 0.25ug(0.25mg specification) or 0.lug(0.1mg specification) per 1 ml as a reference solution. 5ml of the test solution and 5ml of the reference solution were respectively placed in the test tube of the stopper, and then added with 5.OML of absolute ethanol and 1.0ml of vanadium pentoxide solution, which were shaken and placed at 30 ° C. For 1 hour, the fluorescence intensity was measured at an excitation light wavelength of 0405 nm and an emission light wavelength of NM according to a fluorescence analysis method (General description), and the elution amount per sheet was calculated. The limit is 70% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
operation in the dark. Take 20 tablets of this product, such as sugar-coated tablets should be removed from the coating, precision weighing, fine, precision weighing an appropriate amount (equivalent to reserpine 0.5mg), put 100ml Brown measuring bottle, heated water 10ml, shake well, add 10ml of trimethyl methane, shake, dilute to the scale with ethanol, shake well, filter, and take the filtrate accurately, quantitatively dilute with ethanol to make a solution containing about 2ug of reserpine per 1 ml, as a test solution; Take another 10 mg of reserpine reference substance, put it in a 100ml brown measuring flask, add 10ml of trichloromethane to dissolve reserpine, dilute to scale with ethanol, shake; Take 2ml of precision, put 100ml brown flask, dilute to scale with ethanol, shake, as a reference solution. Take 5ml of each of the reference solution and the test solution respectively, place them in the test tube of the stopper, add 2.0 ml of the vanadium pentoxide test solution, and place them at 30 ° C for 1 hour after vigorous shaking, according to the fluorescence analysis method (General rule 0405), the fluorescence intensity was measured at an excitation light wavelength of NM and an emission light wavelength of NM, and calculated.
category
with reserpine.
specification
(1)0.lmg (2)0.25mg
storage
shading, sealed storage.
Last Update：2022-01-01 11:57:50
RESERPINE(RG) - Reserpine injection
Authoritative Data Verified Data
This product is a sterile aqueous solution of reserpine. The content of reserpine (C33H40N209) shall be between 90.0% and 110.0% of the label amount.
trait
This product is a clear liquid with yellowish green color and fluorescence.
identification
- take an appropriate amount of this product (about 25mg of reserpine), add 10ml of water and 5ml of ammonia test solution, extract with 10ml of chloroform, separate the three-gas methane layer, and put it on a water bath to evaporate. The residue showed the same reaction according to the tests of identification (1), (2) and (3) under reserpine.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
- the pH value should be 2.5 to 3.5 (General 0631).
- the related substances were protected from light. Take this product and dilute it with methanol to make a solution containing 1 mg of reserpine per 1 ml as a test solution. Take 1 ml for precision measurement, put it in a 100ml measuring flask, and dilute it to the scale with mobile phase, as a control solution. If there are impurity peaks in the chromatogram of the test solution, the sum of each impurity peak area shall not be more than 3 times (3.0%) of the main peak area of the control solution.
- bacterial endotoxin take this product, according to the law inspection (General 1143), each 1 mg reserpine Endotoxin content should be less than 71EU.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Acetonitrile -1% ammonium acetate solution (46:54) as mobile phase; The detection wavelength was 268nm. The number of theoretical plates shall not be less than 4000 calculated by reserpine peak; The separation degree between reserpine peak and adjacent impurity peaks shall meet the requirements.
- The assay was operated in the dark. Take an appropriate amount of this product with precision and quantitatively dilute it with methanol to make a solution containing about 20ug of reserpine per lml as a sample solution. Take 20 u1 with precision and inject it into the liquid chromatograph to record the chromatogram; another precision weigh about 12.5mg of reserpine reference, put it in a 50ml measuring flask, add 1.5ml of chloroform to dissolve, dilute to the scale with methanol, shake well, take 2ml of precision and put it in a 25ml measuring flask, dilute with methanol to the scale, shake, the same method. According to the external standard method to calculate the peak area, that is.
category
with reserpine.
specification
(l) lml:lmg (2)lml:2.5mg
storage
light shielding, closed storage.
Last Update：2022-01-01 11:57:51
RESERPINE(RG) - Compound Reserpine Tablets
Authoritative Data Verified Data
This product contains reserpine (C33H40N209) should be 85.0% ~ 115.0% of the label amount; Containing hydrogen thiazide (C7H8C1N304S2), promethazine hydrochloride (C17H20N2S • HC1), vitamin B1(C12H17ClN4OS • HC1) vitamin B6(C8H11NO3 • HC1) and dihydralazine sulfate (C8H10N6 • H2S04) should be between 90.0% and 110.0% of the labeled amount.
prescription
reserpine 32Mg
Hydrochlorothiazide 3.lg
Dihydralazine sulfate 4.2g
Promethazine hydrochloride 2.lg
Vitamin A 1.0g
Vitamin B6 1.og
Calcium pantothenate 1.og
Magnesium Trisilicate 30g
Potassium chloride 30g
Appropriate amount of excipients
Made into 1000 tablets
trait
This product is white-like to yellowish tablets or film-coated tablets, sugar-coated tablets, remove the coating, appeared white to yellowish.
identification
- in the chromatograms recorded under the determination of reserpine, hydrochlorothiazide and promethazine hydrochloride, the retention time of the three main peaks in the test solution should be consistent with the retention time of the corresponding three main peaks in the control solution.
- in the chromatograms recorded under the determination of bishydralazine sulfate, vitamin B1, and vitamin B6, the retention time of the three main peaks in the test solution should be consistent with the retention time of the corresponding three main peaks in the control solution.
- Take 10 tablets of this product, remove the sugar coating, grind it finely, put it in an evaporation dish, heat and burn it to remove the possible ammonium salt, let it cool, transfer it to a plug Erlenmeyer flask, Add 10ml of water to dissolve it, and filter it, the filtrate was transferred to a beaker and a 0.1% solution of Sodium tetraphenylborate and acetic acid were added to form a white precipitate.
- Take 10 tablets of this product, remove the sugar coating, grind it fine, put it in a beaker, add 20ml of water to dissolve it, filter it, take 5ml of the filtrate and put it in a test tube with a stopper, add 2.5 of sodium hydroxide solution, add 0.5ml potassium ferricyanide solution and 5ml n-butanol, shake strongly for 2 minutes, place them in layers, and examine them under UV lamp. The upper alcohol layer shows strong blue fluorescence; alkali was added to make it alkaline, and the fluorescence appeared again.
- add 5ml of filtrate under item (4) of identification, add 5ml of water, shake well, put two test tubes a and B respectively, add 2ml of 20% sodium acetate solution each, and add 5ml of water in a tube, 1ml of chlorimino-2, 6-dichloroquinone solution was added rapidly in each solution. The blue-green color in the nail tube disappeared after a few minutes and turned red-brown, tube B showed no blue color.
- take the test solution under the content determination items of bisfluoroxazine sulfate, vitamin B1 and Vitamin S as the test solution; Take an appropriate amount of calcium pantothenate reference, add 0.1% phosphoric acid solution to dissolve and dilute to prepare 10% solution per 1 ml, as a reference solution, according to the chromatographic conditions under the item of determination of bishydralazine sulfate, vitamin B1 and vitamin B6, the test solution and the reference solution of 20 u1 respectively were injected into the human liquid chromatograph, and the chromatograms were recorded. The retention time of the calcium pantothenate peak in the test solution should be consistent with the retention time of the main peak of the control solution.
examination
- Content uniformity reserpine, hydrochlorothiazide, promethazine hydrochloride, dihydralazine sulfate, vitamin D and vitamin D are operated in the dark. According to the calculation of the content of each tablet measured under the content determination item, it shall comply with the regulations (General rule 0941); Wherein the reserpine limit is 20%.
- dissolution hydrogen thiazide and promethazine hydrochloride light-protected operation. Take this product, according to the dissolution and release determination method (General 0931 second method), to O. 900ml of 1 mol/L hydrochloric acid solution is the dissolution medium, and the rotation speed is 50 revolutions per minute, the operation is carried out according to law. After 45 minutes, about 10ml of the solution is taken and filtered with a micropore filter membrane with a pore size of 0.45um, the continued filtrate was taken as the test solution; The appropriate amount of hydrochlorothiazide reference substance and promethazine hydrochloride reference substance were accurately weighed, the diluent was dissolved and quantitatively diluted under the content measurement item to prepare a solution containing 3.4ug hydrogen thiazide and 2.3ug promethazine hydrochloride per 1 ml as a reference solution. The sample solution and the reference solution were respectively 20 u1, except that the mobile phase was [0.06mol/L potassium dihydrogen phosphate solution-methanol (90:10)(pH 3.0)].-Acetonitrile (65:35), according to "reserpine, hydrochlorothiazide and promethazine hydrochloride" content determination method under, the dissolution amount of hydrochlorothiazide and promethazine hydrochloride in each tablet was calculated by peak area according to external standard method. The limit shall be 70% of the labeled amount and shall be in accordance with the regulations.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- light-shielding operation.
- reserpine, hydrochlorothiazide and promethazine hydrochloride were measured by HPLC (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; 0.06mol/L potassium dihydrogen phosphate solution-methanol (90:10)(pH 3.0) as mobile phase A, acetonitrile was used as mobile Phase B, and gradient elution was carried out according to the following table; The detection wavelength was 268mn. The number of theoretical plates shall not be less than 3000 calculated by reserpine peak, and the separation degree between each main peak and other chromatographic peaks shall meet the requirements.
- determination Method: Take 10 tablets of this product, put them in 25ml measuring flasks respectively, and add diluent [sodium acetate solution] (take 9.0g of sodium acetate, add 1000ml of water to dissolve, add 3.0ml of triethylamine, adjust the pH value to 5.0 with glacial acetic acid)-acetonitrile (55:45)] sonicate to dissolve and dilute to the scale, shake well, filter, and take the continued filtrate as the test solution, the chromatogram was recorded by injection of 20u1 into human liquid chromatograph, and the appropriate amounts of reserpine reference substance, hydrochlorothiazide reference substance and promethazine hydrochloride reference substance were separately taken, add diluent to dissolve and quantitatively dilute to prepare a solution containing reserpine 1.28ug, hydrochlorothiazide 124ug and promethazine hydrochloride 84ug per 1 ml, and determine with the same method. The content of each component in each tablet was calculated by peak area according to external standard method, and the average content of each component in 10 tablets was obtained.
- determination of dipyrimidine sulfate, vitamin and vitamin B6 by HPLC (General 0512) ^
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Buffer solution (0.11% sodium hexane sulfonate, 0.02% sodium heptane sulfonate mixed solution, adjust the pH value to 3.5 with glacial acetic acid)-Acetonitrile-methanol (80:10:10) as mobile phase; The detection wavelength was 210Nm. The number of theoretical plates shall not be less than 3000 based on the calculation of bishydralazine sulfate peak; The separation degree between chromatographic peaks shall meet the requirements.
- determination of 10 tablets of this product, respectively, add the appropriate amount of 0.1% phosphoric acid solution, grinding, transfer to a measuring flask, shake for 30 minutes, dilute to the scale with 0.1% phosphoric acid solution, shake, centrifuge, take the supernatant as the test solution, and inject 20u1 into the liquid chromatograph to record the chromatogram. Take the reference substance of bishydrazorecone sulfate and vitamin B accurately, the appropriate amount of each reference substance and vitamin E control substance shall be dissolved and quantitatively diluted with 0.1% phosphoric acid solution to make a solution containing dihydralazine sulfate 42ug, vitamin technology 10ug and Vitamin S 10ug per 1 ml, same method determination. The content of each component in each tablet was calculated by peak area according to external standard method, and the average content of each component in 10 tablets was obtained.
category
antihypertensive drugs.
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:43:23
RESERPINE(RG) - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 24, Sup 7) 1987 |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| properties | white or light yellow crystalline powder; The gas is slight and has no bitter taste. |
| use | reserpine can lower blood pressure and slow down heart rate. its effect is slow, mild and lasting. it has a lasting stabilizing effect on the central nervous system and is a good sedative. During the treatment of hypertensive patients, it can strengthen the effect of lowering blood pressure by attaching topical Chinese medicines such as topical medicine stickers, antihypertensive application stickers, and suspension stickers. Antihypertensive and tranquilizer. The antihypertensive effect is slow but lasting. This product is widely used in the treatment of mild and moderate hypertension. It is often combined with thiazide drugs to increase the efficacy. The drug can be taken for a long time and is well tolerated. Widely used in the treatment of mild and moderate hypertension Inhibition of catecholamine and serotonin uptake. |
| Production method | This line is extracted from the gum chilblain precipitated when the total alkali of the Apocynaceae plant (Rauvolfia) concentrates the acid permeate solution. An alkaloid obtained by chemical synthesis. However, at present, the synthesis method has no production value and is extracted from Rauvolfia. Take the gelatinous substance precipitated when the acid percolate of Rauvola is evaporated and concentrated, add ethanol and glacial acetic acid to obtain an acidic ethanol solution, and then extract it with chloroform to obtain a chloroform solution, and then convert it into nitrate in a weak alkaline solution Extract with acetone, and refine to obtain reserpine. Since the product is extremely prone to oxidation and deterioration, the entire production process must be carried out away from light. The total yield is about 0.01% for raw drugs and about 0.5% for colloids. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 02:00:09
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Spot supply
Product Name: Reserpine Visit Supplier Webpage Request for quotationCAS: 50-55-5
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Multiple SpecificationsSpot supply
Product Name: Reserpine Visit Supplier Webpage Request for quotationCAS: 50-55-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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