RG7420
Cobimetinib
CAS: 934660-93-2
Molecular Formula: C21H21F3IN3O2
RG7420 - Names and Identifiers
RG7420 - Physico-chemical Properties
| Molecular Formula | C21H21F3IN3O2 |
| Molar Mass | 531.31 |
| Density | 1.706 |
| Melting Point | 165 - 166°C |
| Boling Point | 565.9±50.0 °C(Predicted) |
| Solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slig |
| Appearance | Solid |
| Color | Off-White |
| pKa | 13.13±0.20(Predicted) |
| Storage Condition | Refrigerator |
| In vitro study | Cobimetinib exhibits strong inhibitory activity against the growth of a broad group of tumor cells, particularly against BRAF or KRAS mutant cancer cell lines. Binding of GDC-0941,GDC-0973 in 888MEL and A2058 cells resulted in decreased viability, pathway inhibition, and increased apoptosis. Co-administration of GDC-0973 and vemurafenib significantly increased decreased GLUT-1 levels on cell membranes in all BRAF V600E lines. |
| In vivo study | Cobimetinib (10 mg/kg, p.o.) produced anti-tumor effects in mice bearing BRAF V600E and KRAS mutant tumors, which combined GDC-0973 and GDC-0941 to improve efficacy. Binding of GDC-0973 to GDC-0941 induced reduced levels of hexokinase II,c-RAF,Ksr and p-MEK proteins in drug-resistant loading A375 xenograft mice. |
RG7420 - Risk and Safety
| HS Code | 29333990 |
RG7420 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.882 ml | 9.411 ml | 18.821 ml |
| 5 mM | 0.376 ml | 1.882 ml | 3.764 ml |
| 10 mM | 0.188 ml | 0.941 ml | 1.882 ml |
| 5 mM | 0.038 ml | 0.188 ml | 0.376 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Cobimetinib Visit Supplier Webpage Request for quotationCAS: 934660-93-2
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Cobimetinib Visit Supplier Webpage Request for quotation
CAS: 934660-93-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 934660-93-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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