RK24466
7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR
CAS: 213743-31-8
Molecular Formula: C23H22N4O
RK24466 - Names and Identifiers
RK24466 - Physico-chemical Properties
| Molecular Formula | C23H22N4O |
| Molar Mass | 370.45 |
| Density | 1.30±0.1 g/cm3(Predicted) |
| Boling Point | 605.1±55.0 °C(Predicted) |
| Solubility | DMSO: 17mg/mL at≤60°C, soluble |
| Appearance | White solid |
| Color | white |
| pKa | 5.75±0.30(Predicted) |
| Storage Condition | 2-8°C |
| In vitro study | RK-24466 is selective for Lck over a range of receptor, non-receptor tyrosine kinases and seronine/threonine kinases. RK-24466 are potent inhibitors of IL2 production in Jurkat cells stimulated with anti-CD3 antibody, being at least 100-fold more potent than PP1. RK-24466 displays remarkable cellular selectivity. RK-24466 significantly inhibits both VSMC proliferation and migration. RK-24466 suppresses VSMC proliferation and migration via down-regulating the protein kinase B (Akt) and extracellular signal regulated kinase (ERK) pathways, and it significantly decreases the expression of proliferating cell nuclear antigen (PCNA) and cyclin D1 and, the phosphorylation of retinoblastoma protein (pRb). |
| In vivo study | RK-24466 inhibits T-cell receptor stimulated (a-CD3 mAb) IL-2 production in mice at low doses (ED 50 =4 mg/kg) after ip administration. However, efficacy is greatly reduced after oral administration (ED 50 =25 mg/kg) which is presumed to reflect poor intestinal absorption in the latter regimen. Inhibition of antigen specific T-cell immune responses is also seen for RK-24466. After administration of RK-24466 twice daily (100 mg/kg po) for 3 days during the in vivo priming phase, a 70% inhibition of IFNγ production is seen upon subsequent antigen-specific (KLH) challenge of lymphocytes from the draining lymph nodes in vitro . RK-24466 suppresses the migration of VSMCs from endothelium-removed aortic rings, as well as neointima formation following rat carotid balloon injury. |
RK24466 - Risk and Safety
| WGK Germany | 3 |
RK24466 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.699 ml | 13.497 ml | 26.994 ml |
| 5 mM | 0.54 ml | 2.699 ml | 5.399 ml |
| 10 mM | 0.27 ml | 1.35 ml | 2.699 ml |
| 5 mM | 0.054 ml | 0.27 ml | 0.54 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: 7-CYCLOPENTYL-5-(4-PHENOXY)PHENYL-7H-PYR Visit Supplier Webpage Request for quotationCAS: 213743-31-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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