RMC099
URMC-099
CAS: 1229582-33-5
Molecular Formula: C27H27N5
RMC099 - Names and Identifiers
RMC099 - Physico-chemical Properties
| Molecular Formula | C27H27N5 |
| Molar Mass | 421.54 |
| Density | 1.256±0.06 g/cm3(Predicted) |
| Solubility | Soluble in DMSO (>25 mg/ml) |
| Appearance | solid |
| Color | Off-white |
| pKa | 13.49±0.40(Predicted) |
| Storage Condition | -20°C |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Use | URMC-099 is an oral bioeffective mixed lineage kinase 3 (MLK3) (IC50=14 nM) inhibitor with excellent blood-brain barrier penetration. |
| In vitro study | URMC-099 inhibited LPS-induced TNFα release in microglia and HIV-1 Tat-induced cytokine release in human monocytes. URMC-099 prevents the destruction and phagocytosis of cultured axons by microglia. In vitro experiments, URMC-099 reduced fMLP-induced chemotaxis of wild-type neutrophils. URMC-099 inhibited LPS-induced TNFα release in microglia and HIV-1 Tat-induced cytokine release in human monocytes. URMC-099 prevents the destruction and phagocytosis of cultured axons by microglia. In vitro experiments, URMC-099 reduced fMLP-induced chemotaxis of wild-type neutrophils. |
| In vivo study | In mice, URMC-099 showed good pharmacokinetic properties and improved CNS permeability. In vivo, URMC-099 (10 mg/kg I. p.) reduced inflammatory cytokine production, protected neuronal structure, and altered the morphological and ultrastructural response of microglia to HIV-1 Tat exposure. In wild-type mice, URMC099 significantly reduced the entry of neutrophils through fMLP into the peritoneum. In Mice, URMC-099 showed good pharmacokinetic properties and improved CNS permeability. In vivo, URMC-099 (10 mg/kg I. p.) reduced inflammatory cytokine production, protected neuronal structure, and altered the morphological and ultrastructural response of microglia to HIV-1 Tat exposure. In wild-type mice, URMC099 significantly reduced the entry of neutrophils through fMLP into the peritoneum. |
RMC099 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.372 ml | 11.861 ml | 23.723 ml |
| 5 mM | 0.474 ml | 2.372 ml | 4.745 ml |
| 10 mM | 0.237 ml | 1.186 ml | 2.372 ml |
| 5 mM | 0.047 ml | 0.237 ml | 0.474 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: URMC-099 Visit Supplier Webpage Request for quotationCAS: 1229582-33-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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