RO-9187

Name	RO-9187
Synonyms	RO9187 RO-9187 RO 9187 4-Amino-1-(4-C-azido-beta-D-arabinofuranosyl)-2(1H)-pyrimidinone
CAS	876708-03-1

Molecular Formula	C9H12N6O5
Molar Mass	284.22878
Melting Point	188.0-189.0℃
Storage Condition	-20℃
In vitro study	RO-9187 is excellent substrates for deoxycytidine kinase and is phosphorylated with efficiencies up to 3-fold higher than deoxycytidine. RO-9187 inhibits RNA synthesis by HCV polymerases from either HCV genotypes 1a and 1b or containing S96T or S282T point mutations with similar potencies, suggesting no cross-resistance with either R1479 (4′-azidocytidine) or 2′-C-methyl nucleosides. The formation of RO-9187-TP increased in a time- and dose-dependent manner. The maximal triphosphate concentration at 24 h is 87 pmol/106 cells with half-maximal triphosphate formation achieved at 12 μM RO-9187.
In vivo study	Plasma exposures of RO-9187 in rats increase in a dose-dependent manner between 10 and 2000 mg/kg after oral dosing. Plasma concentrations of 1.4 and 26 μM (390 and 7454 ng/mL) are achieved in rats and dogs at the 10 mg/kg dose level, respectively. Plasma concentrations up to 57 μM are achieved in rats dosed with 2000 mg/kg/day.

Last Update：2024-01-02 23:10:35

biological activity	RO-9187 is a potent inhibitor of HCV Virus replication with an IC50 value of 171 nM.
Target	IC50: 171 nM (HCV)

Last Update：2024-04-10 22:29:15

Product Name: RO-9187 Visit Supplier Webpage Request for quotation
CAS: 876708-03-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

Product Name: RO-9187 Visit Supplier Webpage Request for quotation
CAS: 876708-03-1
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

View History

RO-9187

RO-9187 Request for Quotation