RTA408
RTA-408
CAS: 1474034-05-3
Molecular Formula: C33H44F2N2O3
RTA408 - Names and Identifiers
RTA408 - Physico-chemical Properties
| Molecular Formula | C33H44F2N2O3 |
| Molar Mass | 554.71 |
| Density | 1.19±0.1 g/cm3(Predicted) |
| Boling Point | 662.0±55.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 13.71±0.70(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | RTA408 effectively increased the expression of Nrf2 target genes in RAW 264.7 cells and reversed IFNγ-mediated inhibition of Gclc expression. In a panel of 8 human tumor cell lines, RTA 408 inhibited growth with a mean GI50 value of 260 nM and induced apoptosis. In tumor cells, RTA 408 also inhibits NF-κB and activates JNK. |
| In vivo study | In radiation-induced dermatitis mice, 1.0% RTA 408 significantly reduced epidermal and collagen thickness, prevented dermal necrosis, and completely alleviated skin ulcers. In rat skin, RTA 408 activates Nrf2 and induces cytoprotective genes. RTA 408 also reduced hematopoietic acute radiation syndrome in mice. |
RTA408 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.803 ml | 9.014 ml | 18.027 ml |
| 5 mM | 0.361 ml | 1.803 ml | 3.605 ml |
| 10 mM | 0.18 ml | 0.901 ml | 1.803 ml |
| 5 mM | 0.036 ml | 0.18 ml | 0.361 ml |
Last Update：2024-01-02 23:10:35
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Spot supply
Product Name: Omaveloxolone Visit Supplier Webpage Request for quotationCAS: 1474034-05-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Spot supply
Product Name: RTA-408 Visit Supplier Webpage Request for quotationCAS: 1474034-05-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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