Rapitil

Name	Nedocromil
Synonyms	Rapitil Tilarin FPL-59002 Nedocromil NEDOCROMIL FPL-59002KP FPL 59002KP 69049-74-7 (Di-hydrochloride salt) 9-Ethyl-4,6-dioxo-10-propyl-6,9-dihydro-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid 4H-pyrano[3,2-g]quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl- 4H-Pyrano(3,2-G)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-
CAS	69049-73-6
InChI	InChI=1/C19H17NO7/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26)

Molecular Formula	C19H17NO7
Molar Mass	371.34
Density	1.472±0.06 g/cm3(Predicted)
Melting Point	298-300° (dec)
Boling Point	645.5±55.0 °C(Predicted)
Flash Point	344.2°C
Solubility	DMSO: soluble2mg/mL, clear (warmed)
Vapor Presure	1.52E-17mmHg at 25°C
Color	white to beige
pKa	2.19±0.40(Predicted)
Storage Condition	Sealed in dry,2-8°C
Refractive Index	1.64
Physical and Chemical Properties	Yellow crystalline powder. Melting point 298-300 °c (decomposition). Nedocromil Disodium salt: C19H15NO7Na2. [69049-74-7]. Pale yellow crystalline powder.
In vitro study	Nedocromil inhibits the release of histamine, LTC 4 , and PGD 2 from mast cells challenged with antigen (with IC 30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC 30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).
In vivo study	Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.

Hazard Symbols	Xi - Irritant
Risk Codes	36 - Irritating to the eyes
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

Last Update：2024-01-02 23:10:35

biological activity	Nedocromil inhibits the action or formation of a variety of mediators, including histamine, leukotriene C4 (LTC4) and prostaglandin D2 (PGD2).
Use	An asthma preventive drug, which must be administered by inhalation. This product is excreted in the original form, not metabolized, and thus long-term use will not produce accumulation. For reversible airway obstructive diseases, including bronchial asthma, asthmatic bronchitis, new attack asthma, asthma caused by Labor can be used for regular prevention and treatment.
production method	reaction of N, 4-diacetyl-n-ethyl-3-hydroxyaniline with allyl bromide, formation of allyl ether; Heating isomerization of 2-allyl-n, 4-diacetyl-n-ethyl-3-hydroxyaniline; Catalytic hydrogenation of allyl to propyl; the acetyl group on nitrogen is removed by hydrolysis with hydrobromic acid; After the addition reaction of the alkyne bond in the dimethyl butyneate, the methanol is removed under the action of Polyphosphoric acid to form a dihydroquinolinone derivative; And then the ester exchange with diethyl oxalate, condensation cyclization to produce the pyrano [3,2-g] quinoline derivative; Finally hydrolysis of sodium bicarbonate to give nedocromil.

Last Update：2024-04-10 22:29:15

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CAS: 69049-73-6
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Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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