Name | Retigabine |
Synonyms | D2312 D 23129 Retigabin Retigabine ethyl {2-amino-4-[(4-fluorobenzyl)amino]phenyl}carbamate 2-AMINO-4-(4-FLUORBENZYLAMINO)-1-ETHOXYCARBONYLAMINOBENZENE Ethyl [2-amino-4-[[(4-fluorophenyl)methyl]amino]phenyl]carbamate N-(2-Amino-4-(4-fluorobenzylamino)phenyl)carbamic Acid Ethyl Ester |
CAS | 150812-12-7 |
InChI | InChI=1/C16H18FN3O2/c1-2-22-16(21)20-15-8-7-13(9-14(15)18)19-10-11-3-5-12(17)6-4-11/h3-9,19H,2,10,18H2,1H3,(H,20,21) |
Molecular Formula | C16H18FN3O2 |
Molar Mass | 303.331 |
Density | 1.307g/cm3 |
Boling Point | 430°C at 760 mmHg |
Flash Point | 213.9°C |
Solubility | DMSO: >15mg/mL |
Vapor Presure | 1.34E-07mmHg at 25°C |
Appearance | powder |
Color | white to light brown |
BRN | 8072099 |
pKa | 13.12±0.70(Predicted) |
Storage Condition | 2-8°C |
Refractive Index | 1.655 |
Use | Retigabine (D-23129) is a new antispasmodic agent with activity in a wide range of convulsive models. The mechanism of its activity is mainly to open the KCNQ2-5 voltage-gated potassium ion channels of neurons. |
Risk Codes | R23 - Toxic by inhalation R25 - Toxic if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36/37 - Wear suitable protective clothing and gloves. S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
UN IDs | UN 2811 6.1 / PGIII |
WGK Germany | 3 |