S-1670
Sucrose stearate ester
CAS: 25168-73-4
Molecular Formula: C30H56O12
S-1670 - Names and Identifiers
| Name | Sucrose stearate ester |
| Synonyms | S-1670 Sucrapan S sucrose stearate Saccharose stearate SUCROSE MONOSTEARATE Sucrose stearate ester Ryoto sugar ester S 1670 1-O-octadecanoyl-beta-D-fructofuranosyl alpha-D-glucopyranoside alpha-d-glucopyranoside,beta-d-fructofuranosyl,monooctadecanoate .beta.-D-Fructofuranosyl-.alpha.-D-Glucopyranoside,monooctadecanoate 2,5-anhydro-5-(hydroxymethyl)-6-O-octadecanoyl-alpha-D-gluco-D-manno-undec-6-ulopyranose |
| CAS | 25168-73-4 |
| EINECS | 246-705-9 |
| InChI | InChI=1/C30H56O12/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(33)39-20-30(28(38)25(35)22(19-32)41-30)42-29-27(37)26(36)24(34)21(18-31)40-29/h21-22,24-29,31-32,34-38H,2-20H2,1H3/t21-,22-,24-,25-,26+,27-,28+,29-,30+/m1/s1 |
S-1670 - Physico-chemical Properties
| Molecular Formula | C30H56O12 |
| Molar Mass | 608.76 |
| Density | 1.246g/cm3 |
| Melting Point | 67-71 °C |
| Boling Point | 763.216°C at 760 mmHg |
| Flash Point | 235.593°C |
| Water Solubility | Soluble in water and ethanol at 75°C. |
| Solubility | Very slightly soluble in water, sparingly soluble in ethanol (96 per cent). |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Powder |
| Color | White to Off-white |
| Storage Condition | Refrigerator |
| Refractive Index | 1.546 |
| Use | Used as food additives, pharmaceutical excipients, emulsion dispersants |
S-1670 - Upstream Downstream Industry
| Raw Materials | Stearic acid |
S-1670 - Preparation Method
Open Data Verified Data
sucrose and fatty acid methyl ester were added to a dimethylformamide solvent, and the reaction was carried out at 90 to 95 ° C. Using K2 C03 as a catalyst, and methanol and excess sucrose were removed.
Last Update：2022-01-01 09:28:41
S-1670 - Nature
Open Data Verified Data
colorless or yellowish viscous liquid or powder, tasteless. Good dispersion, wetting, solubilization and washing, sterilization. Slightly soluble in water, soluble in ethanol.
Last Update：2024-01-02 23:10:35
S-1670 - Standard
Authoritative Data Verified Data
This product is sucrose stearic acid ester mixture, according to the monoester in the total Ester phase content, mainly divided into sucrose stearate S-3, S-7, S-11 and S-15.
Last Update：2024-01-02 23:10:35
S-1670 - Trait
Authoritative Data Verified Data
- This product is a white to light yellow-brown solid or powder; 3 odor or slightly odor, tasteless.
- This product is dissolved in hot n-butanol, chloroform or tetrahydrofuran, and is very slightly dissolved in water.
acid value
take 4g of this product, precision weighing, add 40ml and 20ml of tetrahydrofuran, slightly heat to dissolve, cool, according to the potential titration method (General 0701), month sodium hydroxide titration solution (0.lmol/L) titration to pH 8.20 for the end point, and the results of the titration with a blank test correction, acid value (General 0713) should not be greater than 5.0.
Last Update：2022-01-01 11:28:11
S-1670 - Use
Open Data Verified Data
can be used as emulsifier, wetting agent, dispersant, solubilizer and emollient. Emulsifier for cosmetics, food, pharmaceutical industry, can also be used in detergents, fiber processing, agriculture and animal husbandry and canned products. When used as emulsifier and preservative in food, the dosage is 1~1.5g/kg.
Last Update：2022-01-01 09:28:41
S-1670 - Differential diagnosis
Authoritative Data Verified Data
- take 0.5g of this product, add 20ml of n-butanol and 20ml of 5% chlorinated solution (preheated to 40-60°C), shake to dissolve, stand still, and remove the aqueous layer, the n-butanol layer was then washed twice with 40ml of 5% sodium chloride solution (preheated at 340-60°C), and about 2ml of the n-butanol layer was taken, about 3ml of anthrone test solution was slowly added along the wall to form a layer, which was heated in a 60 ° C. Water bath for 3 minutes. Blue to green appeared at the contact surface of the two liquid layers.
- in the chromatogram recorded under the fatty acid composition check item, the retention time of the methyl palmitate peak and the methyl stearate peak in the Test Bay solution should be consistent with the retention time of the corresponding peak in the control S solution.
Last Update：2022-01-01 11:28:12
S-1670 - Safety
Open Data Verified Data
non-toxic, non-irritating. Rat oral LD50:30000mg/kg.
Last Update：2022-01-01 09:28:41
S-1670 - Exam
Authoritative Data Verified Data
free sucrose
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using amino-bonded silica gel as 3 agent; Using ammonium acetate acetonitrile solution (lOug/ml) as mobile phase A, tetrahydrofuran-water (90:10) solution of acetic acid (10ug/ml) was used as mobile phase B; Tetrahydrofuran-water (87.5: 12.5) was used as diluent; the measurement was performed with an evaporative light scattering device (reference condition: drift tube temperature 45 ° C., carrier gas 2.0L/min). The sucrose reference substance is accurately weighed, dissolved and diluted with diluent to make a solution containing about 0.2mg per 1 ml. 20ul is injected into the human liquid chromatograph, and linear gradient elution is carried out according to the following table, and the chromatogram is recorded, the signal to noise ratio of sucrose peak should be greater than 10, and the separation degree between adjacent peaks should meet the requirements.
- determination Method: Take appropriate amount of sucrose reference substance respectively, weigh it precisely, add diluent to dissolve and quantitatively dilute it respectively, and make it contain about 0.25mg, 0.50mg and l of sucrose per 1 ml. Omg, 2. Solutions of 0mg and 2.5mg were used as control solutions. Accurately take 20ul of each of the above reference solution, inject human liquid chromatograph respectively, record the chromatogram, and calculate the linear regression equation with the logarithmic value of the concentration of the reference solution and the logarithmic value of the corresponding peak area, and the correlation coefficient is O). Should not be less than 0.99; Take an appropriate amount of this product, precision weighing, plus dilution solution dissolved and quantitative dilution made of sucrose stearate 50mg per 1 mL solution, the same method for the determination, using linear regression equation to calculate the content of free sucrose in the test article, should not exceed 4.0%.
loss on drying
take this product, with phosphorus pentoxide as desiccant, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 3.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 1.5%.
Heavy metals
The residue left under the ignition residue item shall not contain more than 20 parts per million of heavy metals as determined by law (general chapter 0821 second method).
arsenic salt
take 2.Og of this product, add 5ml of sulfuric acid and 5ml of nitric acid, slowly heat to boiling, and continuously add 2 ~ 3ml of nitric acid, every time, until the solution is colorless or light yellow, let it cool, add 15ml saturated ammonium oxalate solution, heat to smoke, concentrate to 2-3ml, let it cool, add water to 25ml, and inspect according to law (General Principles 0822, first law), and meet the requirements (0.0001%).
fatty acid composition
take this product O.lg, put in a 50ml Erlenmeyer flask, add 2ml of 0.5mol/L sodium hydroxide methanol solution, heat and reflux in a 65°C water bath for about 30 minutes, cool, add 2ml of 14% trivapor boron methanol solution, then heat and reflux in 65°C water bath for about 30 minutes, cool down, add 4ml heptane, continue heating and reflux in 65°C water bath for 5 minutes, cool down, add 10ml saturated sodium chloride solution, shake well, the mixture was allowed to stand to separate into layers, and 2ml of the upper layer was taken, washed 3 times with 2ml of water each time, and dried over anhydrous sodium sulfate. According to the gas chromatography method (General 0521) test, with bonded polyethylene glycol as stationary liquid, the initial temperature is 130°C, maintained for 2 minutes, at a rate of 5°C per minute to 2 3 0°C, maintained for 18 minutes. The inlet temperature was 220°C and the detector temperature was 270°C. 20mg of the reference substance of lauric acid, myristic acid, palmitic acid and stearic acid were taken respectively, and the reference substance solution was prepared by the same method as above. lul was injected into human gas chromatograph, and the chromatogram was recorded. The resolution of each chromatographic peak should meet the requirements. The upper layer was injected into the gas chromatograph, and the chromatogram was recorded. The peak area was calculated by area normalization method, and both lauric acid and myristic acid were not more than 3.0%, stearic acid was not less than 40.0%, and the total amount of palmitic acid and stearic acid was not less than 90.0%.
monoester content
take about 0.2g of this product, weigh it accurately, put it in a 10ml measuring flask, add chloroform to dissolve and dilute it to the scale, shake it well. According to the thin layer chromatography (General 0502) test, the above solution is absorbed 20ul, and is put on the silica gel G thin layer plate, with chloroform-methanol-glacial acetic acid-water (80:10:8:2) for the development, spread out and take out. The mixture was dried, heated at 100 ° C. For 30 minutes, allowed to cool, sprayed with a Morin solution (Morin 50mg, dissolved in methanol to ML), and examined under a UV lamp (365mn). And divide the monoester (M: The closest one from the origin), diester (D: two to four in the middle) and triester (T: one to four most distant from the origin) spots (single, two, the distance between the three Ester spots is relatively large). Scraping M, D, T Ester spots of silica gel, respectively, put 10ml centrifuge tube, each
Add ethanol (1 ml) and anthrone (7ml) in precision, shake well, heat in 60°C water bath for 20 minutes, let it cool, centrifuge for 15 minutes, rotate at 2500 rpm, take supernatant, as a test solution; The other scraping of the same thin layer plate blank and the same size of the Test spot of silica gel, the same method of treatment as a blank control solution. According to UV-visible spectrophotometry (General rule 0401), the absorbance was measured AT the wavelength of 625nm to obtain Am, AD and, the monoester content (based on 100% of total esters) is calculated according to the following formula, and the monoester content is 0 ~ 24% S-3; 25% ~ 44% S-7; And 45% ~ 64% S-ll; s-15 is not less than 65%.
Last Update：2022-01-01 11:28:13
S-1670 - Category
Authoritative Data Verified Data
pharmaceutical excipients, solubilizers and emulsifiers.
Last Update：2022-01-01 11:28:13
S-1670 - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 11:28:13
S-1670 - Reference Information
| introduction | sucrose stearate is a sucrose ester. Sucrose esters are products obtained by esterification or transesterification of sucrose and fatty acids or fatty acid derivatives. The synthetic raw material of sucrose ester comes from renewable resources, has excellent application performance, good biodegradability and toxicological properties, and the product itself is friendly to the environment and organisms. As an important natural surfactant, it is widely used in food, medicine, cosmetics and detergents. |
| preparation | 1) preparation of ethyl stearate: weigh 42.65g of stearic acid, add it to a three-mouth flask for heating and melting, add 0.5mL of concentrated sulfuric acid and 55mL of absolute ethanol under stirring, and react at about 80 ℃ for 8 hours after the reaction ends. Evaporate ethanol under reduced pressure, neutralize with KOH to pH 6~7, wash with hot water, let the upper liquid of the layer as crude ester, and refine the crude ester to obtain the product. 2) Preparation of sucrose ester Take a certain amount of ethyl stearate, propylene glycol, sucrose and K2CO3, add them into a 250mL three-mouth flask, heat to 90 ℃, end the reaction after a certain period of reaction, add tartaric acid, evaporate most of the solvent under reduced pressure, add the distillation residue to 8% sodium chloride solution under stirring, until the two solutions produce obvious interfacial delamination, and remove the water layer to obtain crude sucrose ester, the crude product was further purified with ethyl acetate and vacuum dried to constant weight to obtain a white waxy solid. |
| use | can improve the processing performance, disintegration performance and dissolution of the drug, thus improving the product quality. it is especially suitable for oral cephalosporins, macrolide antibiotics and penicillin antibiotics, elastase, interferon, N4-acylarabinoside stabilizers and absorption promoters. |
| production method | 3mol of sucrose and 1mol of fatty acid methyl ester are added into dimethylformamide (DMF) solvent, K2CO3 is used as catalyst, and the methanol and excess sucrose are removed after the reaction is carried out at 90-95 ℃ and 10-13kPa pressure. |
Last Update：2024-04-09 20:49:11
Supplier List
Spot supply
Product Name: Sucrose stearate Request for quotationCAS: 25168-73-4
Tel: +86-18162425036
Email: 3866263148@qq.com
Mobile: 18162425036
QQ: 3866263148
Wechat: 18162425036
Product Name: Sucrose stearate ester Request for quotation
CAS: 25168-73-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 25168-73-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Sucrose stearate Visit Supplier Webpage Request for quotation
CAS: 25168-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 25168-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Sucrose stearate Request for quotationCAS: 25168-73-4
Tel: +86-18162425036
Email: 3866263148@qq.com
Mobile: 18162425036
QQ: 3866263148
Wechat: 18162425036
Product Name: Sucrose stearate ester Request for quotation
CAS: 25168-73-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
CAS: 25168-73-4
Tel: 0086-551-65418684
Email: sales@tnjchem.com
info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840
Wechat: 0086 189 4982 3763
WhatsApp: 0086 189 4982 3763
Product List: View Catalog
Product Name: Sucrose stearate Visit Supplier Webpage Request for quotation
CAS: 25168-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 25168-73-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
Raw Materials for S-1670