S-555739
Asapiprant
CAS: 932372-01-5
Molecular Formula: C24H27N3O7S
S-555739 - Names and Identifiers
S-555739 - Physico-chemical Properties
| Molecular Formula | C24H27N3O7S |
| Molar Mass | 501.55 |
| Density | 1.341±0.06 g/cm3(Predicted) |
| Melting Point | >218°C (dec.) |
| Boling Point | 731.6±70.0 °C(Predicted) |
| Solubility | DMSO : 11.11 mg/mL (22.15 mM; Need ultrasonic) |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 2.92±0.10(Predicted) |
| Storage Condition | -20°C Freezer, Under inert atmosphere |
| Use | Asapiprant is a potent and selective DP1 receptor antagonist with a Ki value of 0.44 nM. |
S-555739 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.994 ml | 9.969 ml | 19.938 ml |
| 5 mM | 0.399 ml | 1.994 ml | 3.988 ml |
| 10 mM | 0.199 ml | 0.997 ml | 1.994 ml |
| 5 mM | 0.04 ml | 0.199 ml | 0.399 ml |
Last Update：2024-01-02 23:10:35
S-555739 - In Vivo
Oral administration of Asapiprant to sheep at 1 and 3 mg/kg significantly (P<0.01) suppresses the increase in nasal resistance by 82% and 92%, respectively. Oral administration of Asapiprant to sheep at 5 mg/kg suppresses Prostaglandin (PG) D2 (PGD)2-induced nasal resistance by 86%. When orally administered 1 h before the antigen challenge in pigs, Asapiprant (3, 10, and 30 mg/kg) suppresses immediate airway response (IAR) by 52%, 57%, and 96%, and late airway response (LAR) by 67%, 50%, and 79%, respectively. Orally administered with Asapiprant (5 mg/kg) for 4 days, the Asapiprant significantly (P<0.01) suppresses antigen-induced nasal resistance by 73% in sheep. Treatment with 3 and 30 mg/kg of Asapiprant in pigs significantly (P<0.01) suppresses nasal secretion by 53% and 72%, respectively. Treatment with Asapiprant in rats at 10 mg/kg significantly (P<0.05) reduces airway hyper-responsiveness (AHR), infiltration of inflammatory cells, and mucin production in bronchoalveolar lavage fluid (BALF), although treatment with Asapiprant at 0.1 mg/kg does not have a significant effect on any responses。
Last Update：2023-08-16 21:32:38
Supplier List
Spot supply
Product Name: Asapiprant Visit Supplier Webpage Request for quotationCAS: 932372-01-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Asapiprant Visit Supplier Webpage Request for quotationCAS: 932372-01-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History