S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate
Fluticasone propionate
CAS: 80474-14-2
Molecular Formula: C25H31F3O5S
S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate - Names and Identifiers
S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate - Physico-chemical Properties
| Molecular Formula | C25H31F3O5S |
| Molar Mass | 500.57 |
| Density | 1.32±0.1 g/cm3(Predicted) |
| Melting Point | 275 °C |
| Boling Point | 568.3±50.0 °C(Predicted) |
| Specific Rotation(α) | D +30° (c = 0.35) |
| Flash Point | 288.4°C |
| Solubility | DMSO 100 mg/mL ;Water <1 mg/mL; Ethanol 5 mg/mL |
| Vapor Presure | 1.52E-14mmHg at 25°C |
| Appearance | White Solid |
| Color | white |
| Merck | 14,4211 |
| pKa | 12.53±0.70(Predicted) |
| Storage Condition | Store at RT |
| Refractive Index | 31 ° (C=1, Dioxane) |
| MDL | MFCD00866007 |
| Physical and Chemical Properties | Crystalline, melting point 272-273 °c (decomposition). ^[α]D 30 °(C = 0.35). |
| In vitro study | In human lung fibroblasts, Fluticasone propionate(1 pM) inhibited the constitutive and TGF-β-induced expression of α-SMA. Fluticasone propionate blocks nuclear translocation of the pro-inflammatory transcription factor NF-κB induced by TNF-α in human lung fibroblasts. Fluticasone propionate inhibits IL-13 (tyrosine kinase 2,STAT1,STAT3,STAT6, mitogen-activated protein kinase)-induced activation of the Janus kinase/STAT pathway in the early stages of lung fibroblast differentiation. In mildly or fully differentiated myofibroblast cultures, Fluticasone propionate still exhibited potential anti-inflammatory activity, although it only inhibited phosphorylation of tyrosine kinase 2. In early and mildly differentiated myofibroblasts, Fluticasone propionate inhibited constitutive and TGF-β-induced expression of α-smooth muscle actin, which is a major marker of myofibroblast differentiation. Fluticasone propionate exhibited an additional powerful anti-inflammatory effect, reducing the nuclear translocation of myofibroblast NF-κB independent of its degree of differentiation. Fluticasone propionate inhibited allergen-induced T cell proliferation, expression of IL-3,IL-5, and GM-CSF mRNA, and secretion of the corresponding proteins in a concentration-dependent manner. Fluticasone propionate significantly inhibited allergen-induced T-cell production of asthma-related cytokines. |
| In vivo study | In horses, Fluticasone propionate administration after induction of severe eye deterioration resulted in complete resolution of clinical symptoms, normalization of pulmonary function tests and a significant decrease in bronchoalveolar neutrophil lavage (BAL). |
S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | BV7980000 |
| HS Code | 29372900 |
| Toxicity | LD50 oral in rat: > 2gm/kg |
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View History
S-Fluoromethyl-6alpha,9alpha-difluoro-11beta-hydroxy-16alpha-methyl-3-oxo-17alpha-propionyloxyandrosta-1,4-diene-17beta-carbothioate
2-METHYLACETOPHENONE
(R)-(+)-2-AMINO-4-BUTYROLACTONE HYDROCHLORIDE
m-Nitrochlorobenzen
Bis(dibenzylideneacetone)palladium
4-Benzyloxy-3-chlorobroMobenzene
Glycolic acid, di-TMS
Alkaloid A, fromCoptis groenlandica
tert-Butyl 4-aminobenzoate
聚肌苷酸
2-METHYLACETOPHENONE
(R)-(+)-2-AMINO-4-BUTYROLACTONE HYDROCHLORIDE
m-Nitrochlorobenzen
Bis(dibenzylideneacetone)palladium
4-Benzyloxy-3-chlorobroMobenzene
Glycolic acid, di-TMS
Alkaloid A, fromCoptis groenlandica
tert-Butyl 4-aminobenzoate
聚肌苷酸