SAFFLOWERYELLOWCOLOUR
SAFFRON POWDER
CAS: 1401-20-3
Molecular Formula: C43H44O24
SAFFLOWERYELLOWCOLOUR - Names and Identifiers
| Name | SAFFRON POWDER |
| Synonyms | SAFFRON POWDER CARTHAMIN YELLOW Carthamas yellow SAFFLOWERYELLOWCOLOUR SAFFRON FOR MICROSCOPY SAFFRON ALCOHOLIC SOLUTION FOR MICROSCOPY |
| CAS | 1401-20-3 |
SAFFLOWERYELLOWCOLOUR - Physico-chemical Properties
| Molecular Formula | C43H44O24 |
| Molar Mass | 944.79506 |
| Storage Condition | Room Temprature |
| Physical and Chemical Properties | Yellow or brown-yellow powder, easy to absorb moisture, brown when absorbing moisture, and form a block. The product after moisture absorption does not affect the use effect. Melting point 230 ℃. The light resistance is good, and the color tone is stable in the pH range of 5~7. It is quite stable on heat. When added to the fruit juice, the pigment residue rate is 70% after instantaneous sterilization at 80 ℃. The pH value is 7 and the pigment residue rate is 88.9% when irradiated under sunlight for 8 hours. The dyeability to starch is excellent, and the dyeability to protein is slightly worse. Iron ions can make it black, Ca2, Sn2,. Mg2 +, Cu2 +, "Al3 + plasma has almost no effect. Easily soluble in cold water (alkaline or acidic), hot water, dilute ethanol, dilute propylene glycol, almost insoluble in absolute ethanol, insoluble in ether, petroleum ether, grease and acetone. |
SAFFLOWERYELLOWCOLOUR - Introduction
Mixture
Last Update：2022-10-16 17:41:57
SAFFLOWERYELLOWCOLOUR - References
| 1. Effect on cardiovascular system | 1) dilating coronary artery and improving myocardial blood supply: the myocardial ischemia model was prepared by ligating the anterior descending branch of coronary artery in dogs, safflower yellow can inhibit the increase of lactate dehydrogenase and creatine kinase caused by coronary artery ligation, and can also reduce the ST segment of coronary artery ligation dogs, reduce the degree of myocardial ischemia, reduce the scope of myocardial ischemia, low-dose safflower yellow (10 mg/kg) inhibited the heart rate and the ST segment of myocardial ischemia, high dose (40 mg/kg) of the inhibitory effect on the heart is more obvious and can more significantly improve myocardial ischemia. Safflower yellow exerts its anti-Myocardial ischemia effect by decreasing the myocardial tension time index, increasing the flow of aorta and coronary artery, and protecting myocardial cells. 2) lower blood pressure, dilate blood vessels, and improve organ blood supply: the changes of thoracic aortic ring tension in perfused rats were observed by using biological signal acquisition system, safflower yellow was found to significantly inhibit the contraction of KCl and phenylephrine (PE), endothelium and denervated vascular rings in a concentration-dependent manner. |
| pharmacokinetics | 1. The administration route of ear vein injection was used, and the results showed that safflower yellow in healthy rabbits was a chamber model. Main pharmacokinetic parameters: area under the curve (AUC) was 40192.6 μg/min/ml, half-life (T1/2) was 44.0 min, clearance rate constant was 0.016 min, the renal clearance rate was 1.22/min, and safflower yellow had a good linear relationship in the range of 38~168.29 μg/ml, with a half-life of 44 min, it indicated that the metabolism of safflower yellow in the body had a lag phenomenon. 2. The pharmacokinetics of safflower yellow in rats with acute blood stasis was studied by the way of tail vein administration, results the disposal and metabolism of safflower yellow in blood stasis rats were two-compartment open model, the area under the curve was 49 633 μg/min/ml, and the distribution half-life was 1.43 min, the elimination half-life was 95.65 min. The normal rat model is a compartment model, the area under the curve is 42267 μg/min/ml, and the Half-Life is 66.27 min, the linear range of safflower yellow was 28.7~130.9 μg/ml. Compared with normal rats, the area under the curve of blood stasis in vivo drug time is greatly increased, the content of safflower yellow in normal rats can not be measured for 480 min, and the drug concentration can be measured in blood stasis rats. 3. After intravenous administration, the distribution of safflower yellow in the tested organs from large to small in the order of kidney, liver, lung, spleen, heart and brain, and the amount of drug in each tissue decreased with the extension of time after iv, indicating that the drug is not easy to accumulate in vivo. |
| identification test | soluble in water; Slightly insoluble in ether or ethanol (OT-42) thin layer chromatography the cellulose was activated at 60~80 °c for 20min to make a thin layer chromatography plate. The sample was prepared into 10% methanol solution, and 20 μl was dropped on the plate. After drying, it was developed with a mixture of n-butanol: acetic acid: Water = 4:1:2 (by volume) until the solvent had warmed to about 10cm and then dried. Two main components of safflower yellow appear two yellow spots, Rl value between 0.2~0.5. The aqueous solution of the sample was prepared by color reaction, and alkalized with 10% sodium hydroxide solution. The color should be changed from yellow to orange. The sample was dissolved in citric acid/disodium hydrogen phosphate buffer, pH 5.0, should be yellow, and its maximum absorbance was 400 ~ 408nm. |
| content analysis | accurately weigh about 0.02g of sample and move it to a 200ml volumetric flask, dissolve and volume with citric acid/disodium hydrogen phosphate buffer, pH 5.0. Centrifuge if necessary. The absorbance (A) at 400 ~ 408nm was measured in A 1cm Cuvette, and the content of pigment (P,%) was calculated by using buffer as blank: P =(A/487) x (200/W) x 100 where w-mass of sample, g. If the absorbance is not in the range of 0.2~0.7, the sample volume should be re adjusted. E1 CM1% (safflower yellow A)= 487; Λmax = 400 ~ 408nm. |
| toxicity | ADI is not specified (FAO/WHO,2001). LD50> 20.0g/kg (mouse, oral). |
| usage limit | GB 2760-96: fruit juice (taste) beverages, carbonated beverages, prepared wine, candy, cakes, red and green silk, canned food, plum, ice cream, Popsicle, jelly, preserved fruit, all 0.2g/kg. |
| Use | edible yellow pigment. as a food colorant, China's regulations can be used for all kinds of beverages (especially those with high vitamin content), wine, ice cream, popsicles, candy, cakes, red and green silk, canned, plum, jelly, preserved fruit, the maximum amount of 0.2g/kg. |
| production method | safflower yellow is a yellow pigment contained in the plant safflower of Compositae family. During the flowering period in summer, the yellowish flowers were picked up and extracted by soaking in water. It is concentrated, refined and dried to get safflower yellow. Safflower was soaked in water at room temperature for 4-20h, filtered with gauze, and the residue was extracted 5-6 times until most of the pigment was extracted. If 4~5 tank countercurrent extraction, leaching solution concentration can reach 3% ~ 5%. The leaching solution was filtered and vacuum.(87~97kPa) is concentrated to the relative density of 1.12~1.16(15~20 ° Bé), finally in 90~100 deg C drying or spray drying to obtain powder pigment. The female flower buds of the Asteraceae plant Carthamus tinctorius were extracted with water or weak acid solution, purified, concentrated and dried. The safflower red pigment can be extracted from the insoluble matter in water and alkali solution. |
Last Update：2024-04-09 21:01:54
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CAS: 1401-20-3
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CAS: 1401-20-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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