SAPONINE
Saponin
CAS: 8047-15-2;11006-75-0
Molecular Formula: C27H42O3
SAPONINE - Names and Identifiers
SAPONINE - Physico-chemical Properties
| Molecular Formula | C27H42O3 |
| Density | 1.015-1.020 g/mL at 20 °C (5% in H2O)(lit.) |
| Melting Point | 158℃ |
| Boling Point | 101.9℃[at 101 325 Pa] |
| Water Solubility | Soluble in cold water. |
| Solubility | Soluble in water, insoluble in benzene, chloroform and ether. |
| Vapor Presure | 0.009Pa at 105℃ |
| Appearance | Powder |
| Color | Yellow crystalline |
| Odor | Odorless |
| Merck | 14,8365 |
| Storage Condition | Store at RT. |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00081981 |
| Physical and Chemical Properties | Character: White amorphous powder with irritating odor. solubility soluble in water, insoluble in benzene, chloroform and ether. |
| Use | It is used as emulsifier, foaming agent and preservative, and is also an intermediate for the manufacture of steroid hormone drugs. |
SAPONINE - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R36/37 - Irritating to eyes and respiratory system. R36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. |
| WGK Germany | 2 |
| RTECS | VQ1400000 |
| FLUKA BRAND F CODES | 3 |
| TSCA | Yes |
| HS Code | 29389090 |
SAPONINE - Upstream Downstream Industry
SAPONINE - Reference
| Reference Show more | 1. Lai Xu Qian, Zhong Shan, Min Wang Chao, et al. Optimization of tea saponin purification by response surface methodology [J]. Grain and Oil Processing (electronic version) 2015 000(012):78-84. 2. Li Guo-Wu [1], Gong Zhi-Hua [1], Duan Yi-Fan [1], etc. Separation and Purification of tea saponin from tea seed cake by macroporous adsorption resin [J]. Journal of Food Safety and quality testing, 2018. 3. Tang Wendi, Li Guoqing, Huang Jun, etc. Comprehensive extraction of saponin and Polyphenol from Camellia oleifera [J]. Journal of Guangxi Normal University (Natural Science Edition), 2019, v.37(02):135-142. 4. Li Xiaoran, Mao Tao, Zheng Cheng, et al. Microwave-assisted extraction and surface properties of tea seed saponin [J]. Fine Chemicals, 2018(8). 5. Zhang Yongshi, Liao Huawei, Zhou xiongjian. Preliminary Study on separation and purification of tea saponin [J]. Scientific Information, 2019, v.17;No.565(28):38-39. 6. Wang Ling, Fang Xuezhi, du Menghao, long Qi Zhi. Effects of supercritical CO_2 extraction on oil quality and physicochemical properties of tea saponin in Camellia oleifera cake [J]. China Oils, 2020,45(08):109-114. 7. Wang Jiajia, Li Guoyu, Zhang Yan, Liao Na, Wei Zhencheng, Li Qiaoling. Establishment of continuous multistage reverse water extraction process of tea saponin from camellia seed meal [J]. Journal of Food Science and Technology, 2021,39(01):153-161. 8. Dong, Zhijun, et al. "Effect of tea saponin on ephyrae and polyps of the moon jellyfish Aurelia sp. 1." Plos one 12.8 (2017): e0182787.https://doi.org/10.1371/journal.pone.0182787 9. Xiaoyan, Zheng, et al. "Study on stability and in vitro digestion of camellia oil nanoemulsion system." E3S Web of Conferences. Vol. 189. EDP Sciences, 2020. https://doi.org/10.1051/e3sconf/202018902010 10. Gong, W., Huang Y., Ji, A., Peng, W., Liu, C., Zeng, Y., Yang, R., Yan, L., Wang, X. and Sheng, J. (2018), Optimisation of saponin extraction conditions with Camellia sinensis var. assamica seed and its application for a natural detergent. J. Sci. Food Ag 11. Li Zhigang, et al. "Fabrication of the tea saponin functionalized reduced graphene oxide for fast adsorptive removal of Cd (II) from water." Applied Physics A 124.5 (2018): 1-12.https://doi.org/10.1007/s00339-018-1816-x 12. [IF=4.742] Xiaoping Zhang et al."A vaccine targeting basic fibroblast growth factor elicits a protective immune response against murine melanoma."Cancer Biol Ther. 2018;19(6):518-524 13. [IF=3.978] Hongfei Yu et al."The effect of triterpenoid saponins on pancreatic lipase in vitro: Activity, conformation, kinetics, thermodynamics and morphology."Biochem Eng J. 2017 Sep;125:1 14. [IF=3.174] Hejun Ren et al."Synthesis and characterization of saponin-modified Fe3O4 nanoparticles as heterogeneous Fenton-catalyst with enhanced degradation of p-nitrophenol."J Chem Technol Biot. 2017 Jun;92(6):1421-1427 15. [IF=2.584] Li Zhigang et al."Fabrication of the tea saponin functionalized reduced graphene oxide for fast adsorptive removal of Cd(II) from water."Appl Phys A- Mater. 2018 May;124(5):1-12 16. [IF=9.297] Yuanyuan Zhang et al."High hydrostatic pressure-assisted micellar media as an efficient and green strategy to extract artemisinin from Artemisia annua L.."J Clean Prod. 2021 Nov;324:129245 17. [IF=7.086] Qiqi Li et al."Effective extraction and recovery of rare earth elements (REEs) in contaminated soils using a reusable biosurfactant."Chemosphere. 2020 Oct;256:127070 18. [IF=3.833] Limao Fan et al."Triterpenoid saponins in tea (Camellia sinensis) plants: biosynthetic gene expression content variations, chemical identification and cytotoxicity."Int J Food Sci Nutr. 2021;72(3):308-323 19. [IF=7.491] Xinyu Yang et al."Tea saponin additive to extract eleutheroside B and E from Eleutherococcus senticosus by ultrasonic mediation and its application in a semi-pilot scale."ULTRASONICS SONOCHEMISTRY. 2022 May;86:106039 |
SAPONINE - Nature
Open Data Verified Data
White amorphous powder with irritating odor. Soluble in water, insoluble in benzene, chloroform and ether. With shaking with water, a large amount of foam was generated.
Last Update：2024-01-02 23:10:35
SAPONINE - Preparation Method
Open Data Verified Data
after the raw materials such as dioscoreae and Dioscorea zingiberensis are soaked in water, the diosgenin is dissolved, and the extract is subjected to pressure hydrolysis in the presence of sulfuric acid, neutralized, washed and dried. Extraction with 120# gasoline, followed by crystallization, centrifugal filtration, drying to obtain the finished product.
Last Update：2022-01-01 10:54:37
SAPONINE - Use
Open Data Verified Data
This product is mainly used as medical raw materials, is the manufacture of cortisone, testosterone, progesterone and oral contraceptives and other twenty kinds of steroid hormone raw materials. Can also be used for the preparation of detergents, emulsifiers, foaming agents, preservatives, etc.
Last Update：2022-01-01 10:54:36
SAPONINE - Safety
Open Data Verified Data
This product is non-toxic. Packed in a carton lined with a plastic bag. Storage in a dry, ventilated place, heat, sun, moisture. According to the general storage and transportation of chemical products.
Last Update：2022-01-01 10:54:37
SAPONINE - Reference Information
| LogP | -0.24 at 20℃ |
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| Introduction | saponin, also known as "saponin", "glucoside", is the plant kingdom (Rosaceae, Caryophyllaceae, dioscoreae, etc.) widely distributed a class of complex structure of glycoside compounds (glycoside). Its aqueous solution can produce a permanent foam similar to soap liquid, so called. According to the basic chemical structure of sapogenin produced after the hydrolysis of saponin (sapogenin), generally can be divided into steroidal saponin (exists in the plants of the Digitalis family, has a strong heart effect) and triterpenoid saponin (exists in the soap root, soap skin, no cardiotonic effect) two kinds. |
| Application | , daily chemical used as emulsifier, detergent, foaming agent, also used in pharmaceutical.|
| preparation | a process method for cleaner production of saponin from Dioscorea zingiberensis, which is realized by the following process steps:(1) pretreatment of raw materials: the yellow ginger is washed, crushed with a crusher, and then ground with a mill to form a slurry, so that the particles in the slurry reach 30 mesh, and the mass percentage concentration is 30%;(2) extract saponin slurry: the starch was separated by a variable frequency differential horizontal screw discharge sedimentation centrifuge to obtain saponin slurry. (3) the saponin slurry was placed at room temperature for 36 hours of natural fermentation. Acid hydrolysis: the fermented saponin slurry is put into the hydrolysis tank, acid hydrolysis is carried out with sulfuric acid, and the pressure is controlled at 0.2MPa to obtain the hydrolyzed saponin slurry;(5) Acid washing and water removal: Acid washing and water removal are carried out on the filter press to obtain filter residue; At the same time, sewage is produced;(6) drying: the filter residue is put into a vacuum dryer with steam through the interlayer for drying, and the water content of the filter residue is controlled at 3-5%;(7) the dried filter residue is put into an extraction tank, and 120 gasoline is added, the mass ratio of saponin slurry to gasoline is 5:6, heated to 90 degrees Celsius, and the extraction time is 2 hours to obtain the saponin gasoline mixture; At the same time, the insoluble fiber is separated;(8) the saponin gasoline mixture is concentrated and crystallized to obtain a finished product;(9) the sewage produced in step (5) is discharged into the neutralization tank and reacted with lime, and then enters the electrolytic device for electrolysis, and then into the hydrolysis anaerobic tank for anaerobic biological treatment, Then it enters into three push-flow aeration tanks used in series for biological reaction treatment, and finally enters the sedimentation tank for precipitation. The treated water is completely up to standard, and is recycled for step (1). Neutralization in step (5). |
| Application | application in light industry, chemical industry, pesticide, feed, breeding, textile, oil extraction, mining, building materials and highway construction and other fields saponin can be used for the determination of blood oxygen capacity and oxygen content in clinical tests; The Flame Atomic Absorption spectrophotometric determination of metal in milk detergent; the tumor cells were found in the blood around the white blood cells by electron counting. A secondary metabolite that facilitates the penetration of proteins through cell membranes. It is used as emulsifier, foaming agent and preservative, and is also an intermediate in the manufacture of steroid hormone drugs. Saponin is an amphiphilic glycoside and surfactant. |
| category | toxic substances |
| toxicity grade | poisoning |
| Acute toxicity | oral-mouse LDL0: 3000 mg/kg |
| stimulation data | leaves and berries contain ividin (a toxic saponin), vomit and Diarrhea |
| flammability hazard characteristics | solvent 120# gasoline flammable |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Storage and transportation is separated from oxidant |
| extinguishing agent | dry powder, foam, sand, carbon dioxide, water mist |
Last Update：2024-04-10 22:29:15
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Raw Materials for SAPONINE
Downstream Products for SAPONINE