SB-204990(racemic)
SB 204990
CAS: 154566-12-8
Molecular Formula: C18H22Cl2O5
SB-204990(racemic) - Names and Identifiers
SB-204990(racemic) - Physico-chemical Properties
| Molecular Formula | C18H22Cl2O5 |
| Molar Mass | 389.27 |
| Density | 1.332±0.06 g/cm3(Predicted) |
| Melting Point | 87-89 °C |
| Boling Point | 571.6±40.0 °C(Predicted) |
| pKa | 4.33±0.10(Predicted) |
| Storage Condition | 2-8℃ |
| Use | SB 204990 is a potent and specific inhibitor of ATP citrate lyase (ACLY). |
| In vitro study | SB204990 (SB) is a specific inhibitor of ACLY enzyme. SB204990 treatment leads to a decrease in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels. |
| In vivo study | SB 204990, when administered orally to rats, is absorbed into the systemic circulation. When administered in the diet (0.05-0.25%, w/w) for 1 week, SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels. |
SB-204990(racemic) - Introduction
SB 204990 is a chemical compound whose chemical name is N-(2-chlorophenyl)-2-[2-(2,5-dimethoxyphenyl) ethoxy] acetamide. The following is an introduction to the nature, use, preparation and safety information of SB 204990:
Nature:
-Appearance: The SB 204990 is a light yellow or white solid.
-Molecular formula: C19H20ClNO4
-Molecular weight: 361.82g/mol
-Melting point: About 100-104 ° C
Use:
SB 204990 is mainly used as a chemical reagent for research and development of drugs. It is widely used in the synthesis and optimization of small molecule compounds, especially in the development of anti-tumor drugs.
Preparation Method:
The method of preparing SB 204990 usually involves the following steps:
1. The reaction of 2-chlorophenylacetic acid and dimethylimine to obtain the corresponding aldehyde compound.
2. The aldehyde and the corresponding benzene borate Ester were subjected to copper-catalyzed Suzuki coupling reaction.
3. The resulting compound is subjected to an amidation reaction to obtain the final product SB 204990.
Safety Information:
There are no extensive studies or reports on the safety and toxicity of SB 204990. However, as with any chemical substance, general safe practices should be followed when handling and using SB 204990. This includes wearing appropriate protective equipment (such as gloves and glasses), operating in a well-ventilated area, and keeping it away from substances such as flammables and strong oxidants. During use, care should also be taken to avoid contact and inhalation of this compound. If you come into contact with SB 204990, rinse immediately with plenty of water and seek medical help if necessary.
Nature:
-Appearance: The SB 204990 is a light yellow or white solid.
-Molecular formula: C19H20ClNO4
-Molecular weight: 361.82g/mol
-Melting point: About 100-104 ° C
Use:
SB 204990 is mainly used as a chemical reagent for research and development of drugs. It is widely used in the synthesis and optimization of small molecule compounds, especially in the development of anti-tumor drugs.
Preparation Method:
The method of preparing SB 204990 usually involves the following steps:
1. The reaction of 2-chlorophenylacetic acid and dimethylimine to obtain the corresponding aldehyde compound.
2. The aldehyde and the corresponding benzene borate Ester were subjected to copper-catalyzed Suzuki coupling reaction.
3. The resulting compound is subjected to an amidation reaction to obtain the final product SB 204990.
Safety Information:
There are no extensive studies or reports on the safety and toxicity of SB 204990. However, as with any chemical substance, general safe practices should be followed when handling and using SB 204990. This includes wearing appropriate protective equipment (such as gloves and glasses), operating in a well-ventilated area, and keeping it away from substances such as flammables and strong oxidants. During use, care should also be taken to avoid contact and inhalation of this compound. If you come into contact with SB 204990, rinse immediately with plenty of water and seek medical help if necessary.
Last Update：2024-04-09 21:54:55
