SB480848
Darapladib
CAS: 356057-34-6
Molecular Formula: C36H38F4N4O2S
SB480848 - Names and Identifiers
| Name | Darapladib |
| Synonyms | SB480848 SB 480848 SB 435445 SB-480848 DARAPLADIB Darapladib Darapladib API Darapladib(SB-480848) N-[2-(Diethylamino)ethyl]-N-[4'-(trifluoromethyl)-1,1'-biphenyl-4-ylmethyl]-2-[2-(4-fluorobenzylthio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl]acetamide N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-Cyclopentapyrimidine-1-acetamide N-(2-(Diethylamino)ethyl)-2-(2-((4-fluorobenzyl)thio)-4-oxo-4,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-1-yl)-N-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)acetamide |
| CAS | 356057-34-6 |
SB480848 - Physico-chemical Properties
| Molecular Formula | C36H38F4N4O2S |
| Molar Mass | 666.77 |
| Density | 1.25 |
| Boling Point | 741.0±70.0 °C(Predicted) |
| Solubility | DMSO |
| pKa | 9.03±0.10(Predicted) |
| Storage Condition | Inert atmosphere,Store in freezer, under -20°C |
| In vitro study | During copper-catalyzed human LDL oxidation, Darapladib prevents lyso-PtdCho generation and subsequent monocyte chemotaxis with an IC50 of 4 nM. |
| In vivo study | In WHHL rabbits, Darapladib (30 mg/kg, oral) showed Lp-PLA2 good inhibition of 95% atherosclerosis. Darapladib, as a Lp-PLA inhibitor, attenuates advanced coronary atherosclerosis in pigs with diabetes and hypercholesterolemia (DMHC). In DMHC pigs, darapladib reduced the amount of IgG immunopositive substances permeating the brain and decreased the density of aβ42-containing neurons. |
SB480848 - Introduction
Darapladib (SB-480848) is an irreversible lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor with an IC50 of 0.25 nM.
Last Update：2022-10-16 17:41:37
Supplier List
Spot supply
Product Name: Darapladib Visit Supplier Webpage Request for quotationCAS: 356057-34-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: Darapladib Visit Supplier Webpage Request for quotationCAS: 356057-34-6
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History