SBI115 - Names and Identifiers
SBI115 - Physico-chemical Properties
Molecular Formula | C14H13ClN2O4S
|
Molar Mass | 340.78 |
Solubility | DMSO : 150 mg/mL (Need ultrasonic);H2O : < 0.1 mg/mL (insoluble) |
Storage Condition | 2-8°C |
SBI115 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 2.934 ml | 14.672 ml | 29.344 ml |
5 mM | 0.587 ml | 2.934 ml | 5.869 ml |
10 mM | 0.293 ml | 1.467 ml | 2.934 ml |
5 mM | 0.059 ml | 0.293 ml | 0.587 ml |
Last Update:2024-01-02 23:10:35
SBI115 - Reference Information
biological activity | SBI-115 is a novel antagonist of TGR5 (GPCR19). SBI-115 in Cystic bile duct cells can inhibit cell proliferation, reduce the growth rate of bile duct cells and the level of cAMP. |
Target | Value |
Cell Line:
| shRNA-transfected ADPKD cholangiocytes |
Concentration:
| 100, 200 µM |
Incubation Time:
| 24 hours |
Result:
| Inhibited proliferation (by 32-48%) triggered by pre-treatment of cystic cholangiocytes with TLCA. |
Last Update:2024-04-10 22:29:15