Name | SDZ285-428 |
Synonyms | SDZ 285428 SDZ-285428 SDZ285-428 NVP-VID-400 N-(2-(1H-Imidazol-1-yl)-2-phenylethyl)-4'-chloro-[1,1'-biphenyl]-4-carboxamide [1,1'-Biphenyl]-4-carboxamide, 4'-chloro-N-[2-(1H-imidazol-1-yl)-2-phenylethyl]- |
CAS | 174262-13-6 |
Molecular Formula | C24H20ClN3O |
Molar Mass | 401.89 |
Melting Point | 202-205°C |
Solubility | Chloroform (Slightly), Methanol (Slightly) |
Appearance | Solid |
Color | White to Off-White |
Storage Condition | -20°C, Inert atmosphere |
In vivo study | Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases. |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 2.488 ml | 12.441 ml | 24.883 ml |
5 mM | 0.498 ml | 2.488 ml | 4.977 ml |
10 mM | 0.249 ml | 1.244 ml | 2.488 ml |
5 mM | 0.05 ml | 0.249 ml | 0.498 ml |
biological activity | NVP-VID-400 (SDZ285428) is an inhibitor of CYP51. The I/E2a(5 min) values of NVP-VID-400 (SDZ285428) inhibition T. cruzi and T. brucei were both <1 and I/E2(60 min) values were 9 and 35, respectively. |
target | TargetValue CYP51 () |
Target | Value |
in vivo study | Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases. |