SF-1670

Name	SF1670
Synonyms	SF1670 SF-1670 SF 1670 PTP CD45 Inhibitor SF1670(PTENINHIBITOR) SF1670(PTENinhibitor) 6-PHENYL-2-(2-PYRAZINYL)-4(1H)-PYRIMIDINONE N-(9,10-Dioxo-9,10-dihydro-2-phenanthrenyl)-2,2-diMethylpropanaMide N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
CAS	345630-40-2

Molecular Formula	C19H17NO3
Molar Mass	307.34
Density	1.271±0.06 g/cm3(Predicted)
Boling Point	554.1±29.0 °C(Predicted)
Solubility	10 mM in DMSO
Appearance	Red-violet solid
Color	, light pink to red to very dark purple
pKa	14.31±0.20(Predicted)
Storage Condition	2-8°C
In vitro study	SF1670 showed potent cytotoxicity in HBEC,PC-3,H1299 cells, with IC50 of 5 μm, 10 μm, 44 μm, respectively. SF1670 stimulates the process of angiogenesis in a mouse aortic ring artificial basement membrane angiogenesis model. SF1670 increases chemoattractant-induced PtdIns(3,4,5)P3 signaling in neutrophils and enhances neutrophil function.
In vivo study	In neutropenic peritonitis and bacterial Pneumonia mice, SF1670 pretreatment (500 nM, I. V.) increased Bactericidal Capacity and decreased Pneumonia of Mortality Rate associated with neutropenia.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

Last Update：2024-01-02 23:10:35

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Product Name: SF1670 Visit Supplier Webpage Request for quotation
CAS: 345630-40-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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SF-1670

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