SILANE TBM2

SILANE TBM2 - Names and Identifiers

Name	tert-Butyldimethylsilyl chloride
Synonyms	TBDMCS TBDMSCL TBDMSCI SILANE TBM2 t-butylchlorodimethyl-silan T-BUTYLDIMETHYLCHLOROSILANE t-Butyldimethylchlorosilane t-butyl dimethyl chlorsilane T-BUTYLDIMENHYLSILYL CHLORIDE T-BUTYLDIMETHYLSILYL CHLORIDE tert-Butylchlorodimethylsilane Tert-Butyl Dimethylchlorosilane tert-Butyldimethylsilyl chloride Tert-butyl-dimethyl chlorosilance Tertiary butyldimethylchlorosilane Tert-Butyl Dimethyl Silyl Chloride SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL- (1-chloro-2-methylpropan-2-yl)(dimethyl)silane
CAS	18162-48-6
EINECS	242-042-4
InChI	InChI=1/C6H15ClSi/c1-6(2,5-7)8(3)4/h8H,5H2,1-4H3
InChIKey	BCNZYOJHNLTNEZ-UHFFFAOYSA-N

SILANE TBM2 - Physico-chemical Properties

Molecular Formula	C6H15ClSi
Molar Mass	150.72
Density	0.87g/mLat 20°C(lit.)
Melting Point	86-89 °C (lit.)
Boling Point	125 °C (lit.)
Flash Point	73°F
Water Solubility	Soluble in chloroform and ethyl acetate. Insoluble in water.
Solubility	very sol nearly all common organic solvents such asTHF, methylene chloride, and DMF.
Vapor Presure	60-710Pa at 25℃
Appearance	White powder
Specific Gravity	1.225
Color	white
Exposure Limit	ACGIH: TWA 20 ppmOSHA: Ceiling 300 ppm; TWA 200 ppmNIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
BRN	505999
Storage Condition	Store below +30°C.
Sensitive	Moisture Sensitive
Refractive Index	n20/D 1.46
MDL	MFCD00000501
Physical and Chemical Properties	Density 0.81 melting point 85-91°C boiling point 125°C flash point 22°C
Use	Used as pharmaceutical intermediates and for organic synthesis, as a hydroxyl protective agent in organic synthesis

SILANE TBM2 - Risk and Safety

Risk Codes	R22 - Harmful if swallowed R35 - Causes severe burns R40 - Limited evidence of a carcinogenic effect R34 - Causes burns R10 - Flammable R19 - May form explosive peroxides R11 - Highly Flammable R67 - Vapors may cause drowsiness and dizziness R65 - Harmful: May cause lung damage if swallowed R63 - Possible risk of harm to the unborn child R48/20 - R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R45 - May cause cancer R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R37 - Irritating to the respiratory system R36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S46 - If swallowed, seek medical advice immediately and show this container or label. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S25 - Avoid contact with eyes. S16 - Keep away from sources of ignition. S28 - After contact with skin, wash immediately with plenty of soap-suds. S27 - Take off immediately all contaminated clothing. S33 - Take precautionary measures against static discharges. S29 - Do not empty into drains. S53 - Avoid exposure - obtain special instructions before use. S36/37 - Wear suitable protective clothing and gloves.
UN IDs	UN 2925 4.1/PG 2
WGK Germany	2
RTECS	VV2000000
FLUKA BRAND F CODES	10-21
TSCA	Yes
HS Code	29310095
Hazard Note	Flammable/Corrosive/Moisture Sensitive
Hazard Class	4.1
Packing Group	III

SILANE TBM2 - Reference Information

Open Data Unverified Data

LogP	2.5 at 20℃
NIST chemical information	Information provided by: webbook.nist.gov (external link)
EPA chemical information	Information provided by: ofmpub.epa.gov (external link)
use	auxiliary raw materials for the synthesis of prostaglandins, certain antibiotics, hypolipidemic drugs lovastatin and simvastatin used as pharmaceutical intermediates and Used in organic synthesis, as a hydroxyl protective agent in organic synthesis used in drug intermediates and organic synthesis, is a sterically hindered silicone protective agent, widely used in the synthesis of original drugs. It is used as a protective group for the hydroxyl group in the synthesis of ribonucleosides, and is also an oxidant and decyanating agent. silanizer. As a hydroxyl protective agent in organic synthesis, derivatization reagents are used for analysis and preparation. Protect tertiary alcohols. Reacts with alcohols to form silicone ether. Determination of the conformation of cholesterol derivatives. Synthesis of prostaglandins, auxiliary raw materials for certain antibiotics, lipid-lowering drugs Lofostine (Lovastatin) and Neofostine (Simvastatin).
Production method	The pentane solution of dichlorodimethylsilane is cooled to 0°C, and the pentane solution of tert-butyl lithium is added dropwise under nitrogen and stirring. Maintain 0 ℃, stir for 1.5h, then raise the temperature to 25 ℃, and continue the reaction for 48h. Distillate, collect 125 ℃(97.5kPa) fraction, stand and solidify to obtain tert-butyl dimethylchlorosilane. The yield is 70%.

Last Update：2024-04-09 19:43:38

SILANE TBM2 - Introduction

Sensitive to humidity. Flammable. It's corrosive. Reacts with water, dissolves in ethers and hydrocarbons, and reacts with alcohols, organic acids and amines.

Last Update：2022-10-16 17:14:31

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SILANE TBM2

tert-Butyldimethylsilyl chloride

CAS: 18162-48-6

Molecular Formula: C6H15ClSi

SILANE TBM2 - Names and Identifiers

SILANE TBM2 - Physico-chemical Properties

SILANE TBM2 - Risk and Safety

SILANE TBM2 - Reference Information

Open Data Unverified Data

SILANE TBM2 - Introduction

Supplier List

SILANE TBM2 Request for Quotation

tert-Butyldimethylsilyl chloride

CAS: 18162-48-6

Molecular Formula: C6H15ClSi

SILANE TBM2 - Names and Identifiers

SILANE TBM2 - Physico-chemical Properties

SILANE TBM2 - Risk and Safety

SILANE TBM2 - Reference Information

Open Data Unverified Data

SILANE TBM2 - Introduction

Supplier List

SILANE TBM2