SNK-860
Fidarestat
CAS: 136087-85-9
Molecular Formula: C12H10FN3O4
SNK-860 - Names and Identifiers
| Name | Fidarestat |
| Synonyms | Aldos SNK-860 fidarestat Fidarestat (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione (2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide (2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide (2S,4S)-6-FLUORO-2'',5''-DIOXOSPIRO(3,4-DIHYDRO-2H-1-BENZOPYRAN-4,4''-IMIDAZOLIDINE)-2-CARBOXAMIDE |
| CAS | 136087-85-9 |
| EINECS | 200-258-5 |
SNK-860 - Physico-chemical Properties
| Molecular Formula | C12H10FN3O4 |
| Molar Mass | 279.22 |
| Density | 1.61±0.1 g/cm3(Predicted) |
| pKa | 8.46±0.40(Predicted) |
| Storage Condition | Room Temprature |
| In vitro study | Fidarestat is an inhibitor of aldose reductase, with IC 50 s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. |
| In vivo study | Fidarestat (SNK-860; 1 or 4 mg/kg. p.o., daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats. |
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CAS: 136087-85-9
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CAS: 136087-85-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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