SOPHOCARPINE
sophocarpine
CAS: 145572-44-7
Molecular Formula: C15H22N2O
SOPHOCARPINE - Names and Identifiers
| Name | sophocarpine |
| Synonyms | sophocarpine SOPHOCARPINE Sophocarpinpe Sophora alkaloids Matridine-13-ene-15-one Sophocarpine Monohydrate 13,14-didehydromatridin-15-one (6AS,11AR,11BR,11CS)-2,3,5,6,6A,7,11,11A,11B,11C-DECAHYDRO-1H,4H-3A,7A-DIAZA-BENZO[DE]ANTHRACEN-8-ONE |
| CAS | 145572-44-7 |
| InChI | InChI=1/C15H22N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h1,7,11-13,15H,2-6,8-10H2 |
SOPHOCARPINE - Physico-chemical Properties
| Molecular Formula | C15H22N2O |
| Molar Mass | 246.35 |
| Density | 1.19g/cm3 |
| Melting Point | 8l-2°C |
| Boling Point | 425.4°C at 760 mmHg |
| Specific Rotation(α) | -29.44°（Ethanol） |
| Flash Point | 194°C |
| Solubility | Soluble in methanol, ethanol, chloroform, acetone and benzene, slightly soluble in water, easily soluble in dilute acid. |
| Vapor Presure | 1.92E-07mmHg at 25°C |
| Appearance | White needle crystalline hydrate |
| Color | Pale brownish |
| Storage Condition | -20°C Freezer |
| Refractive Index | 1.603 |
| MDL | MFCD26960838 |
| Physical and Chemical Properties | White needle-like crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from the bitter bean grass, Papaveraceae borgii plants borgii. |
SOPHOCARPINE - Reference
| Reference Show more | 1. Wang Ling, Zhang Ting, Qian Dawei et al. Effects of Volatile Oils of Three Spicy Traditional Chinese Medicines on Transdermal Absorption of Alkaloids from Sophora flavescens [J]. Chinese Journal of Traditional Chinese Medicine 2019 v.44(02):110-115. 2. Liu Liwei Yiyin Pan Wei et al. Simultaneous Determination of Five Active Components in Fushu Zhitou Ointment by GC Method [J]. Journal of Pharmaceutical Analysis 2013 033(011):1882-1886. 3. Shi Xiaoying talks about Wen Pan Song Lijun, etc. HPLC-MS check the blood components of Sophora alopecia alopecia total alkali double-coated pellets [J]. Journal of Liaoning University of Traditional Chinese Medicine 2019 021(004):65-69. 4. Niu Tianzeng, Chen Shilin, Wang Hongfang, et al. Simultaneous Determination of 7 Components in Compound Kushen Injection by One Test and Multiple Evaluation Method [J]. 2019 of Modern Applied Pharmacy in China 36(10):19-24. 5. Zhang Wei, Ma Guizhi, Wang Chunfang, et al. Determination of 4 Alkaloids in Yinxie Formula Granules by One Test and Multiple Evaluation Method [J]. Northwest Journal of Pharmacy 2018(5):595-600. 6. Chang Churui, Lu Pingzhu, Long Qingde. Determination of total alkaloids in different processed products of Sophora flavescens and HPLC fingerprint study [J]. Chinese folk medicine 2018, vol. 27, No. 4, pp. 14-17, 2018. 7. Lu Pingzhu. Optimization of extraction process and determination of total alkaloids in Sophora flavescens leaves [J]. Anhui Agricultural Sciences, v.45; no.558 (17):96-99. 8. [IF = 11.878] Li Xinming et al."A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage." Nat Commun. 2019 Jun;10(1):1-12 9. [IF = 9.811] Manjie Gao et al."High-Crystallinity Covalent Organic Framework Synthesized in Deep Eutectic Solvent: potentially Effective Adsorbents Alternative to Macroporous Resin for Flavonoids." Chem Mater. 2021;33(20):8036-8051 10. [IF = 9.229] Linlin Deng et al."Highly Crystalline Covalent Organic Frameworks Act as a Dual-Functional Fluorescent-Sensing Platform for Myricetin and Water, and Adsorbents for Myricetin." Acs Appl Mater Inter. 2021;13(28):33449-33463 11. [IF = 5.165] Juanning Ren et al."Qualitative and quantitative analysis of multi-components in Xing-Su-Ning Capsules for quality improvement." Arab J Chem. 2022 Jun;15:103825 |
SOPHOCARPINE - Reference Information
| Plant source: | Sophora flavescens |
| biological activity | Sophocarpine (monohydrate) is one of the important alkaloids extracted from traditional herbs Sophora flavescens (Sophora flavescens). Sophora flavescens has many pharmacological effects such as antiviral, antitumor and anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer cells through a variety of mechanisms, such as inducing autophagy (autophagy), activating apoptosis (apoptosis) and downregulating cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been shown to have anti-tumor activity in a variety of cancer cells, including hepatocellular carcinoma, prostate cancer, and colorectal cancer. |
| use | sophocarpine has antitussive, expectorant and antiasthmatic, anti-tumor, analgesic and anti-inflammatory effects. used for content determination/identification/pharmacological experiment, etc. Pharmacological effects: It has an inhibitory effect on the central nervous system and can play an analgesic and anti-inflammatory effect. |
Last Update：2024-04-09 02:00:07
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