SP-146
SP-146
CAS:
Molecular Formula: C₂₅H₂₀FN₇O
SP-146 - Names and Identifiers
SP-146 - Physico-chemical Properties
| Molecular Formula | C₂₅H₂₀FN₇O |
| Molar Mass | 453.47 |
| Storage Condition | -20℃ |
| Use | SP-146 is a highly effective, selective and ATP competitive Aurora B inhibitor. IC50 is 0.316 nM, with> 2000 times selectivity for FLT3 and KIT, IC50 is 1475.6 nM and 1307.6 nM respectively. SP-146 is selective for breast cancer cells such as MDA-MD-468 (GI50=107 nM). SP-146 can be used in the research of triple negative breast cancer (TNBC). |
SP-146 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.205 ml | 11.026 ml | 22.052 ml |
| 5 mM | 0.441 ml | 2.205 ml | 4.41 ml |
| 10 mM | 0.221 ml | 1.103 ml | 2.205 ml |
| 5 mM | 0.044 ml | 0.221 ml | 0.441 ml |
Last Update：2024-01-02 23:10:35
