SPECTINOMYCIN
spectinomycin
CAS: 1695-77-8
Molecular Formula: C14H24N2O7
SPECTINOMYCIN - Names and Identifiers
| Name | spectinomycin |
| Synonyms | spectam spectinomycin spectinomicina spectinomycine actinospectacin espectinomicina antibiotic2233wp actinospectacina 8-bis(methylamino)- 4h-pyrano(2,3-b)(1,4)benzodioxin-4-one,decahydro-4a,7,9-trihydroxy-2-methyl-6, (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one (2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one dihydrochloride |
| CAS | 1695-77-8 |
| EINECS | 216-911-3 |
| InChI | InChI=1/C14H24N2O7.ClH/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;/h5,7-13,15-16,18-20H,4H2,1-3H3;1H/t5-,7-,8+,9+,10+,11-,12-,13+,14+;/m1./s1 |
SPECTINOMYCIN - Physico-chemical Properties
| Molecular Formula | C14H24N2O7 |
| Molar Mass | 332.35 |
| Density | 1.43±0.1 g/cm3(Predicted) |
| Melting Point | 185 °C (decomp) |
| Boling Point | 583.1±50.0 °C(Predicted) |
| Specific Rotation(α) | D25 -20° (water) |
| Flash Point | 306.4°C |
| Vapor Presure | 5.05E-16mmHg at 25°C |
| pKa | pKa1 6.95, pKa2 8.70(at 25℃) |
| Physical and Chemical Properties | Spectinomycin is an alkaline antibiotic, the stronger the alkaline, the stronger its antibacterial effect; But spectinomycin is not soluble in water, so it is often used in clinic as its hydrochloride, white or white crystalline powder, soluble in water. The aqueous solution dissolved in water was acidic, and the PH of the 1% aqueous solution was 3.8-5.6. |
SPECTINOMYCIN - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | spectinomycin is an aminoglycoside fast bactericidal antibiotic formed by the combination of neutral sugar and aminocyclohydrin, also known as spectinomycin and gonorrhea. It was discovered by American Mason in 1961. It is used in the clinical treatment of livestock and poultry veterinarians, and is mainly used to treat diseases caused by E. coli, Salmonella, Pasteurella and Mycoplasma caused by sensitive bacterial infections. spectinomycin is also used to treat respiratory, urinary and biliary tract infections caused by sensitive bacteria. The antibacterial spectrum is basically the same as tetracycline and oxytetracycline, and the antibacterial power in vivo and in vitro is stronger than tetracycline. Microorganisms have close cross-resistance to this product, tetracycline, oxytetracycline, etc. Good oral absorption. It is mainly used for upper respiratory tract infection, flat body inflammation, biliary tract infection, lymphadenitis, cellulitis, chronic bronchitis in the elderly caused by sensitive gram-positive bacteria and gram-negative bacilli. It is also used to treat typhus, Qiang disease, mycoplasma pneumonia, etc. It can also be used to treat cholera and to prevent falciparum malaria and leptospira infection. |
| pharmacological action | the antibacterial mechanism of spectinomycin hydrochloride is the same as other aminoglycoside antibiotics. after entering the bacterial cell, it selectively acts on the 30s subunit of the bacterial cell nucleus proteosome, thus producing a strong inhibitory effect on the protein synthesis of bacterial cells and a strong killing effect on sensitive bacteria. pharmacodynamics spectinomycin belongs to aminoglycoside antibacterial drugs, against a variety of gram-negative bacteria, such as Escherichia coli, Salmonella, Shigella, Proteus and other moderate inhibitory effect. Sensitive to Streptococcus, pneumococcus, Staphylococcus epidermidis and certain mycoplasmas (such as Mycoplasma gallisepticum, Mycoplasma turkey, Mycoplasma synovial fluid). Streptococcus viridans and Staphylococcus aureus are mostly insensitive. Intestinal bacteria are widely resistant to spectinomycin, but do not show cross-resistance with streptomycin. Lincomycin has good antibacterial activity against anaerobic bacteria, such as Clostridium, Streptococcus, Clostridium tetani, etc. Lincomycin mainly acts on the 50S subunit of the bacterial ribosome and affects protein synthesis by inhibiting the extension of the peptide chain. pharmacokinetics spectinomycin is only absorbed by 7% after oral administration, but maintains a high concentration in gastrointestinal tract. The tissue concentration of the drug is lower than the serum concentration. It is not easy to enter cerebrospinal fluid or eye, and the binding rate with plasma protein is not high. Most drugs are discharged through glomerular filtration in their original form. Lincomycin has poor oral absorption and can absorb 30% ~ 40% dosage. Food can reduce its absorption rate and amount. |
| product features | 1. spectinomycin has strong antibacterial power, low toxic and side effects, large safety factor and extremely low drug residue, and is commonly used in clinic. 2. spectinomycin has strong penetrating power to tissues and cells, and has a wide range of treatment. It can directly act on the ribosome of Mycoplasma septicum, solve the role of bacterial adhesion, and also act on Escherichia coli, Salmonella, Mycoplasma septicum. 3. The addition of special ingredients to this product can reduce the polysaccharide fiber and protein secreted by respiratory tract inflammation, reduce the viscosity of sputum, become thinner, easy to cough up, quickly relieve respiratory symptoms, and relieve the respiratory symptoms of mycoplasma. 4. Adding special excipients to this product can obviously improve the absorption degree of spectinomycin, so that Daguan can play a better role when it plays a role. |
| Veterinary clinical | Spectinomycin hydrochloride is a broad-spectrum rapid fungicide, which is effective against Escherichia coli, Salmonella, Pasteurella, Proteus, Streptococcus, Erysipelas filamentous bacteria, Staphylococcus aureus, Streptococcus hemolyticus, Streptococcus pneumoniae, Pneumonia and Mycoplasma caused livestock and poultry diseases, especially for mixed infection of Mycoplasma and Escherichia coli. In veterinary pharmacology, spectinomycin is mostly used to prevent and treat colibacillosis, avian cholera, and avian salmonellosis. It is often combined with lincomycin to prevent acute and chronic respiratory diseases caused by piglet diarrhea, mycoplasma pneumonia and mycoplasma septicum. What needs to be reminded is that whether it is spectinomycin hydrochloride or spectinomycin sulfate, it is necessary for grassroots veterinarians to pay attention to the kidney health of sick livestock and poultry (kidney disease is forbidden for livestock and poultry). The oral administration of livestock and poultry, since the listing of spectinomycin hydrochloride, there are not too many reports in this regard, so there is no need to consider this issue. |
| drug interaction | (1) combined with lincomycin can significantly increase the antibacterial activity against mycoplasma and expand the antibacterial spectrum. (2) The combination of lincomycin and anticholinesterase drugs can reduce the efficacy of the latter. (3) combined with erythromycin has antagonistic effect. (4) combined with opioid analgesics can lead to prolonged respiratory depression or respiratory paralysis. |
Last Update：2024-04-09 21:32:01
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CAS: 1695-77-8
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Mobile: 18021002903
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