SR-12813
Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate; SRL; HTMT dimaleate; 1ilh; 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol
CAS: 126411-39-0
Molecular Formula: C24H42O7P2
SR-12813 - Names and Identifiers
| Name | Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate SRL HTMT dimaleate 1ilh 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol |
| Synonyms | SRL 1ilh SR12813 SR 12813 SR-12813 GW485801 GW 485801 GW-485801 HTMT dimaleate SR-12813(GW 485801) 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate [[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-phosphonicacidtetraethylester Phosphonic acid, P,P'-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]ethenylidene]bis-, P,P,P',P'-tetraethyl ester |
| CAS | 126411-39-0 |
SR-12813 - Physico-chemical Properties
| Molecular Formula | C24H42O7P2 |
| Molar Mass | 504.53 |
| Melting Point | 119-121℃ |
| Solubility | 10 mM in DMSO |
| Appearance | solid |
| Storage Condition | Sealed in dry,Room Temperature |
| Target | IC50: 0.85 μM (HMG-CoA Reductase) |
| In vitro study | SR12813 is a very potent activator of human and rabbit-derived PXR with EC50 of 200 nM and 700 nM, respectively. The activation of PXR in rats and mice is very weak. SR-12813 inhibited the integration of tritiated water into cholesterol with an IC50 of 1.2 μm, but had no effect on fatty acid synthesis. SR-12813 reduced intracellular HMG-CoA reductase activity, with an IC50 of 0.85 μm, it inhibited HMG-CoA reductase activity very rapidly, T1/2=10 min. |
| In vivo study | SR12813 is able to lower cholesterol levels in many animals such as rats, dogs and primates. |
SR-12813 - Risk and Safety
| WGK Germany | 3 |
| HS Code | 29319090 |
SR-12813 - Reference
| Reference Show more | 1. Berkhout T, et al. The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Biol Chem. 1996 Jun 14;271(24):14376-82.2. Jiang W, et al. Forward genetic screening for regulators involved in cholesterol synthesis using validation-based insertional mutagenesis. PLoS One. 2014 Nov 26;9(11):e112632.3. Sergio C Chai, et al. Small-molecule modulators of PXR and CAR. Biochim Biophys Acta.2016 Sep;1859(9):1141-1154. |
SR-12813 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.982 ml | 9.91 ml | 19.82 ml |
| 5 mM | 0.396 ml | 1.982 ml | 3.964 ml |
| 10 mM | 0.198 ml | 0.991 ml | 1.982 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.396 ml |
Last Update：2024-01-02 23:10:35
SR-12813 - Reference Information
| biological activity | SR-12813 is an agonist of pregnane X receptor (PXR). |
| Target | Value |
| pregnane X receptor | |
| HMG-CoA reductase | 850 nM |
Last Update：2024-04-09 20:49:11
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Product Name: Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate; SRL; HTMT dimaleate; 1ilh; 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol Visit Supplier Webpage Request for quotationCAS: 126411-39-0
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Product Name: Tetraethyl 2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate; SRL; HTMT dimaleate; 1ilh; 4-[2,2-bis(diethoxyphosphoryl)ethenyl]-2,6-ditert-butylphenol Visit Supplier Webpage Request for quotationCAS: 126411-39-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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