SRT1720
SRT1720
CAS: 1001645-58-4
Molecular Formula: C25H24ClN7OS
SRT1720 - Names and Identifiers
SRT1720 - Physico-chemical Properties
| Molecular Formula | C25H24ClN7OS |
| Molar Mass | 506.02236 |
| Density | 1.58 |
| Melting Point | >205°C (dec.) |
| Solubility | Soluble in DMSO (>25 mg/ml) |
| Appearance | Liquid |
| Color | White |
| Storage Condition | = -70C |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Use | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, which is more than 230 times weaker than SIRT2 and SIRT3. |
| In vitro study | The maximum activation rate of SRT1720 against the nearest acetylase homologs SIRT2 (EC1.5 at 37 μm) and SIRT3 (EC1.5 > 300 μm) was 781%. SRT1720 binds to the SIRT1 enzyme-peptide substrate complex at the allosteric site of the amino-terminal catalytic region, reducing the Michaelis constant value of the acetylated substrate. After one week of treatment with SRT1720, the Fed glucose level decreased, and after three weeks of treatment, the Fed glucose level decreased further, and the treatment continued for 10 weeks. Rosiglitazone activates PPARγ and has been used in the treatment of type II diabetes, while compared with Rosiglitazone, treatment with SRT1720 resulted in a significant decrease in glucose during the peritoneal glucose tolerance test. SRT1720 had no effect on mice fed a sugar-free diet, showing that activation of pharmacological SIRT1 does not produce hypoglycemia. Similar to Rosiglitazone, treatment with SRT1720 for 4 weeks significantly reduced hyperinsulinemia, restored some of the elevated insulin levels to normal srt1720-treated gastrocnemius, and increased mitochondrial capacities by 15% as measured by citrate synthase activity. High concentration of SRT1720 (15 μm) induced a slight decrease in normal cell viability, about 10-20%. SRT1720 significantly inhibited VEGF-dependent MM cell migration. |
| In vivo study | After caloric restriction in the DIO mice, including improved insulin sensitivity, normal glucose and insulin levels, and increased mitochondrial capacity, SRT1720 was observed to mimic a number of functions. In addition, SRT1720 increased insulin sensitivity, decreased plasma glucose, and increased mitochondrial capacity in diet-induced and genetically obese mice. Thus, SRT1720 is a promising new therapeutic agent for the treatment of diseases like type II diabetes. Consistent with improved glucose tolerance, the glucose injection rate (GIR) required to maintain normoglycemia was approximately 35% in srt1720-treated fa/fa mice, the overall glucose treatment efficiency improvement was approximately 20%. SRT1720 inhibits multiple myeloma growth when studied in animal tumor models. SRT1720 increases the toxicity of Bortezomib or Dexamethasone. |
SRT1720 - Reference
| Reference Show more | 1. [IF=2.984] Sumin Sun et al."Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway."PeerJ. 2022 May;10:e13376 2. [IF=5.882] Sumin Sun et al."Modification of lysine deacetylation regulates curcumol-induced necroptosis through autophagy in hepatic stellate cells."PHYTOTHERAPY RESEARCH |
SRT1720 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 1.976 ml | 9.881 ml | 19.762 ml |
| 5 mM | 0.395 ml | 1.976 ml | 3.952 ml |
| 10 mM | 0.198 ml | 0.988 ml | 1.976 ml |
| 5 mM | 0.04 ml | 0.198 ml | 0.395 ml |
Last Update：2024-01-02 23:10:35
SRT1720 - Reference Information
| biological activity | SRT1720 is a selective SIRT1 activator with EC50 of 0.16 μM, which is more than 230 times weaker than SIRT2 and SIRT3. SRT1720 HCl is a selective SIRT1 activator. EC50 is 0.16 μM in cell-free test, and its effect on SIRT2 and SIRT3 is more than 230 times weaker. SRT1720 can also induce autophagy. |
| Target | Value |
| SIRT1 (Cell-free assay) | 0.16 μM(EC50) |
Last Update：2024-04-09 20:52:54
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Spot supply
Product Name: SRT1720 Hydrochloride Visit Supplier Webpage Request for quotationCAS: 1001645-58-4
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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