SS28
SS28
CAS: 141172-08-9
Molecular Formula: C18H20O3
SS28 - Names and Identifiers
SS28 - Physico-chemical Properties
| Molecular Formula | C18H20O3 |
| Molar Mass | 284.35 |
| Density | 1.089±0.06 g/cm3(Predicted) |
| Boling Point | 414.3±40.0 °C(Predicted) |
SS28 - References
| biological activity | SS28 is a SRT501 analog with oral bioavailability, which can inhibit tubulin polymerization, cell cycle arrest was induced at G2/M. SS28 causes apoptosis rather than necrosis. |
| Target | Tubulin. |
| Cell Line: | CEM, Reh, Nalm6, SUDHL8, Molt4, A549, HeLa 293T cells. CEM and A549 cells. |
| Concentration: | 1, 5, 10 and 20 μM. 2 μM (CEM) and 5 μM (A549). |
| Incubation Time: | 48 and 72 h. 6, 12, 18, 24 and 30 h. |
| Result: | CEM and A549 exhibited maximum sensitivity to SS28 followed by SUDHL8, Molt4 and Reh, whereas Nalm6 showed moderate sensitivity after 48 h of the treatment. IC 50 values of SS28 in CEM and A549 cell line were 2.6 and 5.2 μM, respectively, whereas in SUDHL8, Molt4, Reh and Nalm6 were 2.7, 5.1, 7.9 and 21 μ M, respectively after 48 h of treatment. Showed significant accumulation of cells at G2/M phase in a time-dependent manner (6 to 24 h) and a subsequent increase in the sub-G1 population, indicative of apoptosis at 30 h in case of A549. Similarly, studies in CEM also showed a distinct G2/M arrest after 12 h of treatment, as compared to vehicle control. There was no further tumor progression in the mice when SS28 was administered, unlike the untreated tumor control mice. |
| Animal Model: | BALB/c mice using EAC cells. |
| Dosage: | 15 mg/kg. |
| Administration: | Orally on every alternate day for 9 doses. |
Last Update：2024-04-09 15:17:00
