ST072042
A2793
CAS: 88349-90-0
Molecular Formula: C13H12ClNO3
ST072042 - Names and Identifiers
ST072042 - Physico-chemical Properties
| Molecular Formula | C13H12ClNO3 |
| Molar Mass | 265.69 |
| Density | 1.291±0.06 g/cm3(Predicted) |
| Boling Point | 393.4±27.0 °C(Predicted) |
| Solubility | Soluble in DMSO |
| pKa | 1.97±0.29(Predicted) |
| Storage Condition | -20℃ |
| Use | A2793 is an efficient dual TWIK-related acid-sensitive K+ channel (TASK)-1/TRESK inhibitor, with an IC50 of 6.8 μM for mTRESK. A2764 is more selective for TRESK, and it only moderately influences TREK-1 and TALK-1 |
| In vitro study | A2793 (100 µM) inhibits the unstimulated channel by 43.0±8.9% (n=5) while after ionomycin activation the reduction of the TRESK current is 85.5±2.9% (n=5). A2793 inhibits TASK-1 (100 µM, 53.4±13,5%, n=5), while A2764 is more selective for TRESK, it only moderately influences TREK-1 and TALK-1. A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells which do not express TASK-1. |
ST072042 - Reference
| Reference Show more | [1]. Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. |
ST072042 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
| 10 mM | 0 ml | 0 ml | 0 ml |
| 5 mM | 0 ml | 0 ml | 0 ml |
Last Update：2024-01-02 23:10:35
ST072042 - Reference Information
| biological activity | A2793 (Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate) is TWIK-related spinal cord potential channel (TRESK, k2P18, KCNK18) and TASK-1 (KCNK3), The IC50 value for mouse TRESK was 6.8 μm. |
| Target | Value |
| mTRESK (Cell-free assay) | 6.8 μM |
Last Update：2024-04-09 21:11:58
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CAS: 88349-90-0
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CAS: 88349-90-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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