ST2825

Name	ST 2825
Synonyms	ST2825 ST 2825 (2R,4'R,8'aR)-1-[2-[4-[[2-(2,4-Dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxospiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide Spiro[pyrrolidine-2,7'(6'H)-[2H]pyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide, 1-[2-[4-[[2-(2,4-dichlorophenoxy)acetyl]amino]phenyl]acetyl]tetrahydro-6'-oxo-, (2R,4'R,8'aR)-
CAS	894787-30-5

Molecular Formula	C27H28Cl2N4O5S
Molar Mass	591.51
Density	1.51±0.1 g/cm3(Predicted)
Boling Point	939.0±65.0 °C(Predicted)
Solubility	10 mM in DMSO
pKa	12.86±0.70(Predicted)
Storage Condition	-20℃
In vitro study	ST2825 blocks IL-1R/TLR signaling by interfering with MyD88 homodimerization. ST2825 inhibits this interaction in a concentration-dependent manner with ~40% inhibition of dimerization at 5 μM ST2825 and 80% inhibition at 10 μM ST2825.
In vivo study	ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. The animals are administered orally with the appropriate vehicles or ST2825 at doses ranging from 50 to 200 mg/kg, 5 min prior to i.p. injection with 20 μg/kg IL-1β. ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg.

Last Update：2024-01-02 23:10:35

biological activity	ST 2825 is a specific MyD88 dimerization inhibitor. ST 2825 interferes with the recruitment of IRAK1 and IRAK4 by MyD88 and inhibits IL-1β-mediated NF-κB transcriptional activity.
Target	MyD88
in vitro study	ST2825 blocks IL-1R/TLR signaling by interposing with MyD88 homodiderivation. ST2825 indications this interaction in a concentration-dependent manner with ~ 40% inhibition of differentiation at 5 μm ST2825 and 80% inhibition at 10 μm ST2825.
in vivo study	ST2825 dose-dependently inhibits IL-1β-induced production of IL-6 in treated mice after oral administration. The animals are administered orally with the appropriate vehicles or ST2825 at orders ranging from 50 to 200 mg/kg, 5 min prior to I .p. injection with 20 μg/kg IL-1β. ST2825 exertes a significant inhibition of IL-1β-stimulated production of IL-6 at 100 and 200 mg/kg.

Last Update：2024-04-09 21:01:54

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CAS: 894787-30-5
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Product Name: ST 2825 Visit Supplier Webpage Request for quotation
CAS: 894787-30-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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ST2825

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