SULFONAPHTHAL
Phenol Red
CAS: 143-74-8
Molecular Formula: C19H14O5S
SULFONAPHTHAL - Names and Identifiers
| Name | Phenol Red |
| Synonyms | PR Phenol Red SULFONAPHTHAL TIMTEC-BB SBB006473 PHENOLSULFONPHTHALEIN Phenol Red, indicator Phenolsulfonphthalein Phenolsulfonephthalein PHENOL REDRESEARCH GRADE PHENOSULFOHEPHTHALEIN INDICATOR PHENOL RED FREE ACID CELL CULTURE TESTED 3,3-BIS(P-HYDROXYPHENYL)-2,1-3H-BENZOXATHIOLE 4,4'-(1,1-dioxido-3H-2,1-benzoxathiole-3,3-diyl)diphenol Phenol, 4,4'-(3H-2,1-benzoxathiol-3-ylidene)bis-, S,S-dioxide A-HYDROXY-A A-BIS(P-HYDROXYPHENYL)-O-TOLUENESULFONIC ACID G-SULTONE |
| CAS | 143-74-8 |
| EINECS | 205-609-7 |
| InChI | InChI=1/C19H14O5S/c20-15-9-5-13(6-10-15)19(14-7-11-16(21)12-8-14)17-3-1-2-4-18(17)25(22,23)24-19/h1-12,20-21H |
| InChIKey | BELBBZDIHDAJOR-UHFFFAOYSA-N |
SULFONAPHTHAL - Physico-chemical Properties
| Molecular Formula | C19H14O5S |
| Molar Mass | 354.38 |
| Density | 1.445 Mg m-3 |
| Melting Point | >300 °C |
| Boling Point | >300°C |
| Flash Point | >300°C |
| Water Solubility | 0.77 g/L |
| Solubility | 1 M NaOH: soluble1mg/mL |
| Vapor Presure | 2.84E-13mmHg at 25°C |
| Appearance | Deep red crystalline powder |
| Color | Red |
| Odor | Odorless |
| Maximum wavelength(λmax) | ['557nm, 558nm, 360nm, 423nm, 433nm'] |
| Merck | 14,7247 |
| BRN | 326470 |
| pKa | 7.9(at 25℃) |
| PH | 6.8～8.4 |
| Storage Condition | no restrictions. |
| Refractive Index | 1.5300 (estimate) |
| MDL | MFCD00003552 |
| Physical and Chemical Properties | Deep red crystalline powder. 1g of this product is soluble in 1300ml water, about 350ml alcohol, 500ml acetone, almost insoluble in ether and chloroform, soluble in hydroxide alkali or carbonate alkali solution is deep red, stable in the air. |
| Use | Used as acid-base indicator |
SULFONAPHTHAL - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R34 - Causes burns |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. |
| WGK Germany | 3 |
| RTECS | SJ7490000 |
| TSCA | Yes |
| HS Code | 29349990 |
| Toxicity | LD50 orl-rat: >600 mg/kg CTOXAO 4(2),185,71 |
SULFONAPHTHAL - Reference
| Reference Show more | 1. Chen Weiyu Qian Yafanggu Man Cang Li Nanqi. Absorption of Vanilla Saponin B in Small Intestine by Self-emulsifying Drug Delivery System with Different Charges [J]. Science and technology bulletin 2015 31(11):110-113. 2. ren chaohui. study on expectorant, antitussive and anti-inflammatory effects of hundred-tailed ginseng [J]. Anhui agricultural sciences, v.43;No.480(11):116-118. 3. [IF = 4.411] Xu Zhang et al."In Vitro and In Situ Characterization of the Intestinal Absorption of Capilliposide B and Capilliposide C from Lysimachia capillipes Hemsl." Molecules. 2019 Jan;24(7):1227 4. [IF = 5.571] Tianxiang Shen et al."The study of intestinal absorption and biodistribution in vivo of propon pump inhibitors." Eur J Pharm Biopharm. 2020 Apr;149:135 5. [IF = 5.037] Xindong Jiang et al."An analysis of the biopharmaceutical behaviour of proton pump inhibitors with different physicochemical properties." Life Sci. 2021 Dec;286:120042 |
SULFONAPHTHAL - Introduction
Acid-base indicator; blood carbon dioxide total measurement. Indicator for preparing disaccharide iron urea medium in bacterial serum test, etc.
Last Update：2022-10-16 17:13:56
SULFONAPHTHAL - Reference Information
| pH indicator color change ph range | 6.6(YELLOW)-8.0(RED) |
| main applications | Display device, sol-gel matrix, photoreceptors, fuel cells, waveguides, paints, detergents, cosmetics, antiperspirant composition, diapers, screening bacteria, detecting viable cells, diagnosis of urogenital ureaplasmosis, treatment of pathogen infections, amyloid-associated diseases, glaucoma, pulmonary hypertension, asthma, chronic obstructive pulmonary disease, erectile dysfunction, Raynaud's syndrome, heparin overdose, vulvodynia, wound healing, psychoactive drugs, evaluating dental caries activity |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | phenol red, also known as phenol red, is a dark red crystalline powder with a molecular weight of 354.38 and a CAS number of 143- 74-8. Soluble in water, alcohol, acetone, almost insoluble in ether and chloroform. It is soluble in hydroxide or carbonate. The solution is dark red, stable in the air, and can be used for identification medium in microbial culture; acid-base refers to indicator; blood carbon dioxide Total measurement; instructions for preparing disaccharide iron urea medium in bacterial serum test agent, etc. |
| preparation method | preparation method of phenol red solution: 0.1g phenol red and 5.7 mL 0.05 mol/L NaOH solution are ground in a mortar, dissolved in pure water to prepare 250 mL test solution. |
| application | is used as a raw material for the production of phenolic resin, caprone and adipic acid, and is also used in the plastic and pharmaceutical industries. Acid-base refers to indicator; determination of total blood carbon dioxide; indication of preparation of disaccharide iron urea medium in bacterial serum test agent, etc. |
| overview of risks | phenol red has strong corrosive effect on skin and mucous membrane, and can inhibit central nervous system or damage liver and kidney functions. Acute poisoning: Inhalation of high concentrations of vapor can cause headache, dizziness, fatigue, blurred vision, pulmonary edema, etc. Ingestion causes gastrointestinal burns, burning pain, exhaled air with phenol smell, vomit or stool can carry blood, gastrointestinal perforation may occur, shock, pulmonary edema, liver or kidney damage may occur, acute renal failure may occur, Can die of respiratory failure. Eye contact can cause burns. It can cause acute renal failure after a certain incubation period after being absorbed by the burned skin. Chronic poisoning: can cause headache, dizziness, cough, loss of appetite, nausea, vomiting, severe cases cause proteinuria. Can cause dermatitis. |
| first aid measures | skin contact: immediately remove contaminated clothing, wipe with glycerin, polyethylene glycol or polyethylene glycol and alcohol mixture (7:3), and then wash thoroughly with water. Or rinse with plenty of flowing water for at least 15 minutes. Medical treatment. eye contact: immediately lift the eyelids and rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes. Medical treatment. Inhalation: Quickly leave the scene to fresh air. Keep the airway unobstructed. If breathing is difficult, give oxygen. If breathing stops, artificial respiration is performed immediately. Medical treatment. Intake: immediately drink 15~30mL of vegetable oil. To induce vomiting. Medical treatment. |
| toxicology | acute toxicity: LD50:317 mg/kg (rat oral);850 mg/kg (rabbit percutaneous) LC50:316 mg/m3 (rat inhalation) irritation: rabbit eye: 1mg, severe irritation. Rabbit percutaneous: 500mg/24 hours, severe stimulation. |
| main reference | [1]https://wenku.baidu.com/view/bcc2839e02768e9950e738b9.html. [2]https://wenda.so.com/q/1365064549060489. [3]https://wenku.baidu.com/view/4006a3c0f8c75fbfc77db24c.html. [4] https://wenku.baidu.com/view/f97b3a4ca9956bec0975f46527d3240c8447a1c 0.html. [5]http://www.lnleheng.com/chanpin10benfenhong.html. |
| use | used as acid-base indicator, color change range pH:6.8 (sulfonate)-8.4 (red). It is also used in biochemical research. acid-base indicator, color change range pH:6.8 (yellow)-8.4 (red). Determination of total blood carbon dioxide, indicator of disaccharide iron urea medium prepared in bacterial serum test. Its sodium salt is used to determine liver function. It is also used in biochemical research. |
| production method | co-thermal melting of o-sulfobenzoic anhydride and phenol, adding anhydrous zinc chloride and reacting at 135-140 ℃ for 7h, then pouring the condensate into hot water, filtering, washing the solid with water, and further purifying by acid-base precipitation to obtain the finished product. |
Last Update：2024-04-10 22:29:15
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