Saloxium
salicylylsalicylic acid
CAS: 552-94-3
Molecular Formula: C14H10O5
Saloxium - Names and Identifiers
| Name | salicylylsalicylic acid |
| Synonyms | Salina diagen Salysal Saloxium salflex salgesic disalcid salsitab salsalate amigesic sasapyrine mono-gesic Salicyl-salicylate salicyloylsalicylicacid salicylylsalicylic acid 2-salicylsalicylic acid Salicyloxysalicylic acid Salicyloylsalicylic acid salicylicacid,bimolecularester 2-[(2-hydroxybenzoyl)oxy]benzoic acid 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoate 2-hydroxybenzoic acid 2-carboxyphenyl ester |
| CAS | 552-94-3 |
| EINECS | 209-027-4 |
| InChI | InChI=1/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)/p-1 |
Saloxium - Physico-chemical Properties
| Molecular Formula | C14H10O5 |
| Molar Mass | 258.23 |
| Density | 1.3326 (rough estimate) |
| Melting Point | 139-151 °C |
| Boling Point | 361.48°C (rough estimate) |
| Flash Point | 188°C |
| Water Solubility | HYDROLYSIS |
| Solubility | Soluble in water (hydrolyzes slowly), DMSO (52 mg/ml at 25 °C), ethanol (52 mg/ml |
| Vapor Presure | 3.88E-10mmHg at 25°C |
| Appearance | White crystal |
| Color | white to tan |
| Merck | 14,8339 |
| pKa | pKa 3.5 (Uncertain);9.8 (Uncertain) |
| Storage Condition | 2-8°C |
| Sensitive | Moisture Sensitive |
| Refractive Index | 1.4825 (estimate) |
| MDL | MFCD00020252 |
| Physical and Chemical Properties | Melting point 148-151°C water-soluble hydrogen |
| Use | Used as analgesic and anti-inflammatory drugs |
Saloxium - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R50 - Very Toxic to aquatic organisms R22 - Harmful if swallowed |
| Safety Description | S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | DH2080000 |
| TSCA | Yes |
| HS Code | 29182300 |
Saloxium - Standard
Authoritative Data Verified Data
This product is 2-Hydroxybenzoic acid -2-carboxyl phenyl ester. Calculated as dried product, containing no less than 99.0% of C14H10O5.
Last Update：2024-01-02 23:10:35
Saloxium - Trait
Authoritative Data Verified Data
- This product is white crystalline powder; Odorless.
- This product is soluble in ethanol or ether, and almost insoluble in water.
melting point
The melting point of this product (General 0612) is 140~146°C.
Last Update：2022-01-01 11:33:06
Saloxium - Differential diagnosis
Authoritative Data Verified Data
take about 0.5g of this product, add 5ml of sodium hydroxide solution, boil and show the identification reaction of salicylate (General rule 0301).
Last Update：2022-01-01 11:33:07
Saloxium - Exam
Authoritative Data Verified Data
chloride
take 1.0g of this product, add 20ml of water, shake, filter, take 4ml of filtrate, check according to law (General rule 0801), and compare with the control solution made of 1 ml of standard sodium chloride solution, no more concentrated (0.005%).
sulfate
take 5ml of filtrate under chloride examination, add 1 ml of dilute hydrochloric acid and 3ml of barium chloride test solution, and no turbidity.
free salicylic acid
take this product l.O g, add chloroform 20ml to dissolve, as a test solution; Take about 25mg of salicylic acid, precision weighing, 100ml flask, add chloroform dissolved and diluted to the scale, shake, 20ml was accurately measured and used as a control solution. Put the above two solutions in the separatory funnel, and extract 4 times with ferric nitrate solution [Take lg of ferric nitrate, dissolve with nitric acid solution (0.1-100), and dilute to 1000ml], 20ml each time, take the ferric nitrate solution, filter, put it in a 100ml measuring flask, dilute it to the scale with ferric nitrate solution, and shake it well. The absorbance was measured at a wavelength of 0401 NM according to UV-Vis spectrophotometry (general rule). The absorbance of the test solution shall not be greater than that of the control solution.
loss on drying
take this product, with phosphorus pentoxide as desiccant, at 60°C under reduced pressure drying to constant weight, weight loss should not exceed 0.5% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Heavy metals
take 5ml of filtrate under chloride check item, add several drops of sodium sulfide test solution, and the solution should not develop color.
Last Update：2022-01-01 11:33:07
Saloxium - Content determination
Authoritative Data Verified Data
take this product about 0.5g, precision weighing, add ethanol 40ml to dissolve, add phenolphthalein indicator solution 0.2 ml, with sodium hydroxide titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 25.82mg of C14H10O5.
Last Update：2022-01-01 11:33:08
Saloxium - Category
Authoritative Data Verified Data
antipyretic analgesic, non-steroidal anti-inflammatory drugs.
Last Update：2022-01-01 11:33:08
Saloxium - Storage
Authoritative Data Verified Data
light shielding, sealed storage.
Last Update：2022-01-01 11:33:08
Saloxium - Double salicylate tablets
Authoritative Data Verified Data
This product contains double salicyl ester (C14H1005) should be the label amount of 95.0% ~ 105.0%.
trait
This product is white tablet.
identification
take an appropriate amount of fine powder of this product (about 0.3g of salicylate bihydrate), add 5ml of sodium hydroxide solution, shake to dissolve the salicylate dihydrate, filter, and boil the filtrate, according to the identification test under the double water Yang Ester, the same reaction was shown.
examination
- free salicylic acid: take an appropriate amount of fine powder of this product (about 0.3g of salicylate bissalicinate), weigh it accurately, put it in a separatory funnel, and add 50ml of chloroform to dissolve the salicylate, add 2.5ml of 1 mol/L hydrochloric acid solution and 7.5ml of water, shake, separate the chloroform layer, filter, wash with 10ml of chloroform, and combine the chloroform solution as the test solution; another about 45mg of salicylic acid was added to a 50ml measuring flask, then chloroform was added to dissolve and dilute to the scale, and then the mixture was shaken. Put the above two solutions in the separatory funnel, and extract 4 times with ferric nitrate solution [Take lg of ferric nitrate, dissolve with nitric acid solution (0.1-100), and dilute to 1000ml], 20ml each time, take the ferric nitrate solution, filter, put it in a 100ml measuring flask, dilute it to the scale with ferric nitrate solution, and shake it well. The absorbance was measured at a wavelength of 0401 NM according to UV-Vis spectrophotometry (general rule). The absorbance of the test solution shall not be greater than that of the control solution.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
Take 20 tablets of this product, precise weighing, fine grinding, precise weighing appropriate amount (about equivalent to 0.3g of double water Poplar ester), add 40ml of ethanol, shake to dissolve double water Poplar Ester, phenolphthalein indicator solution 0.2, with sodium hydroxide titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of sodium hydroxide titration solution (0.1 mol/L) corresponds to 25.82mg of C14H10O5.
category
The same as salicylate.
specification
0.3g
storage
light shielding, sealed storage.
Last Update：2022-01-01 11:33:09
Saloxium - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | bissalicylate (salsalate,SAL) is a salicylic acid dimer connected to head and tail, which does not stimulate gastric mucosa and has no inhibitory effect on platelets. Salicylic acid drugs are common non-steroidal anti-inflammatory drugs. They are widely used as antipyretic, analgesic, anti-inflammatory and anti-rheumatic drugs. Their effects on lowering blood sugar and preventing thrombotic diseases have also attracted attention. |
| pharmacological effects | bissalicylate is similar to aspirin, and has antipyretic, analgesic and anti-inflammatory effects. |
| biological activity | Sasapyrine (Salsalate, NSC-49171) is an oral non-steroidal anti-inflammatory drug. |
| use | as an analgesic and anti-inflammatory drug |
Last Update：2024-04-09 21:21:28
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Spot supply
Product Name: Acetylsalicylic Acid Impurity 5（Acetylsalicylic Acid EP Impurity E） Visit Supplier Webpage Request for quotationCAS: 552-94-3
Tel: 0714-3999186
Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052
Wechat: 15671228036
Product Name: Salicylsalicylic Acid Visit Supplier Webpage Request for quotation
CAS: 552-94-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 552-94-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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