Sapresta

Name	ARANIDIPINE
Synonyms	MPC-1304 Sapresta ARANIDIPINE Asanidipine 3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester
CAS	86780-90-7

Molecular Formula	C19H20N2O7
Molar Mass	388.37
Density	1.284±0.06 g/cm3(Predicted)
Melting Point	155°
Boling Point	530.0±50.0 °C(Predicted)
pKa	2.56±0.70(Predicted)
Storage Condition	2-8°C
Physical and Chemical Properties	Yellow prismatic crystals are obtained from ethyl acetate-hexane with a melting point of 155 ℃. Acute toxicity LD50 male and female mice, male and female rats (mg/kg):143,193,1982,1459 oral administration. Acute toxicity LD50 male and female mice (mg/kg):7.3,9.1 intraperitoneal injection.
In vivo study	Aranidipine (MPC-1304) is a new Ca 2+ channel antagonist in spontaneously hypertensive rats. Following oral administration of Aranidipine at doses of 3 and 10 mg/kg to spontaneously hypertensive rats (SHR), there are significant decreases in B max values for specific [ 3 H](+)-PN 200-110 binding to myocardial membranes compared to the control values. The B max values at 1 h (3 mg/kg), 1 and 6 h (10 mg/kg) are significantly decreased (47.7, 48.9 and 25.8%, respectively) compared to the control values. The effect is greatest at 1 h and decreases with time. The B max values at 6 h (3 mg/kg) and 12 or 24 h (10 mg/kg) after the oral administration of Aranidipine are not significantly different from the control values, suggesting the disappearance of the effect of Aranidipine. The K d values for myocardial [ 3 H](+)-PN 200-110 binding are unaltered by oral administration of Aranidipine.

Toxicity

LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano)

Last Update：2024-01-02 23:10:35

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CAS: 86780-90-7
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QQ: 3008007409

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