Saxagliptin
Saxagliptin
CAS: 361442-04-8
Molecular Formula: C18H25N3O2
Saxagliptin - Names and Identifiers
| Name | Saxagliptin |
| Synonyms | Onglyza BMS477118 BMS 477118 Saxagliptin SAXAGLIPTIN Saxagliptin 15ND2 Saxagliptin(BMS 477118) (1S,3S,5S)-2-[2(S)-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-tricyclo[3.3.13,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo-[3.1.0]hexane-3-carbonitrile |
| CAS | 361442-04-8 |
| EINECS | 1308068-626-2 |
| InChI | InChI=1/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1 |
Saxagliptin - Physico-chemical Properties
| Molecular Formula | C18H25N3O2 |
| Molar Mass | 315.41 |
| Density | 1.35 |
| Melting Point | 103 - 107°C |
| Boling Point | 548.7±35.0 °C(Predicted) |
| Flash Point | 548.7℃ |
| Solubility | DMSO (Slightly), Methanol (Sparingly) |
| Vapor Presure | 2.51E-14mmHg at 25°C |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 15.12±0.40(Predicted) |
| Storage Condition | 2-8°C |
| Stability | Temperature Sensitive |
| Refractive Index | 1.64 |
| In vitro study | Inhibition of DPP4 by Saxagliptin has an inhibition constant Ki of 1.3 nM, which is 10-fold more potent than that of villagcliptin or sitagliptin (two other DPP4 inhibitors) with K I of 13 and 18 nM, respectively. In addition, Saxagliptin was more specific for DPP4 than DPP8 or DPP9 enzymes (400-and 75-fold, respectively). The active metabolite of Saxagliptin is 2 times less potent than Saxagliptin. Compared to a range of other proteases (> 2600 and <250-fold selectivity for DPP4 for sitagliptin and villagliptin over DPP8 and DPP9, respectively), both Saxagliptin and its active metabolite were highly selective (>4000-fold) for inhibition of dpp4. Saxagliptin reduces the degradation of the intestinal hypoglycemic hormone glucagon-like polypeptide -1, thereby enhancing its effect, and is associated with improved beta cell function and inhibition of glucagon secretion. |
| In vivo study | In Zucker |
Saxagliptin - Risk and Safety
| Risk Codes | R28 - Very Toxic if swallowed R38 - Irritating to the skin R41 - Risk of serious damage to eyes R48 - Danger of serious damage to health by prolonged exposure |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| UN IDs | 3077 |
| HS Code | 29339900 |
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Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
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Product Name: Saxagliptin Visit Supplier Webpage Request for quotationCAS: 361442-04-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185
Wechat: chinaskyrun
Multiple SpecificationsSpot supply
Product Name: BMS-477118 Visit Supplier Webpage Request for quotationCAS: 361442-04-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: Saxagliptin Visit Supplier Webpage Request for quotationCAS: 361442-04-8
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
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View History
Saxagliptin
182181-19-7
Ban-Hoe
N-Phenylimidazole
VAROX 130-XL
1-Piperazinecarboxylicacid,4-ethyl-,ethenylester(9CI)
3-Furanol, 5-hexyltetrahydro-, acetate
Resveratrol tris(methyl carbonate)
Phenol, p-fluoro-
(3-chloro-2-hydroxy-propyl) prop-2-enoate
182181-19-7
Ban-Hoe
N-Phenylimidazole
VAROX 130-XL
1-Piperazinecarboxylicacid,4-ethyl-,ethenylester(9CI)
3-Furanol, 5-hexyltetrahydro-, acetate
Resveratrol tris(methyl carbonate)
Phenol, p-fluoro-
(3-chloro-2-hydroxy-propyl) prop-2-enoate