Saxagliptin 15ND2

Name	Saxagliptin
Synonyms	Onglyza BMS477118 BMS 477118 Saxagliptin SAXAGLIPTIN Saxagliptin 15ND2 Saxagliptin(BMS 477118) (1S,3S,5S)-2-[2(S)-Amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxy-tricyclo[3.3.13,7]dec-1-yl)-1-oxoethyl]-2-azabicyclo-[3.1.0]hexane-3-carbonitrile
CAS	361442-04-8
EINECS	1308068-626-2
InChI	InChI=1/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1

Molecular Formula	C18H25N3O2
Molar Mass	315.41
Density	1.35
Melting Point	103 - 107°C
Boling Point	548.7±35.0 °C(Predicted)
Flash Point	548.7℃
Solubility	DMSO (Slightly), Methanol (Sparingly)
Vapor Presure	2.51E-14mmHg at 25°C
Appearance	Solid
Color	White to Off-White
pKa	15.12±0.40(Predicted)
Storage Condition	2-8°C
Stability	Temperature Sensitive
Refractive Index	1.64
In vitro study	Inhibition of DPP4 by Saxagliptin has an inhibition constant Ki of 1.3 nM, which is 10-fold more potent than that of villagcliptin or sitagliptin (two other DPP4 inhibitors) with K I of 13 and 18 nM, respectively. In addition, Saxagliptin was more specific for DPP4 than DPP8 or DPP9 enzymes (400-and 75-fold, respectively). The active metabolite of Saxagliptin is 2 times less potent than Saxagliptin. Compared to a range of other proteases (> 2600 and <250-fold selectivity for DPP4 for sitagliptin and villagliptin over DPP8 and DPP9, respectively), both Saxagliptin and its active metabolite were highly selective (>4000-fold) for inhibition of dpp4. Saxagliptin reduces the degradation of the intestinal hypoglycemic hormone glucagon-like polypeptide -1, thereby enhancing its effect, and is associated with improved beta cell function and inhibition of glucagon secretion.
In vivo study	In Zucker

Risk Codes	R28 - Very Toxic if swallowed R38 - Irritating to the skin R41 - Risk of serious damage to eyes R48 - Danger of serious damage to health by prolonged exposure
Safety Description	S24/25 - Avoid contact with skin and eyes. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
UN IDs	3077
HS Code	29339900

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CAS: 361442-04-8
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Email: 2853786052@qq.com
Mobile: 86+15671228036
QQ: 2853786052

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Saxagliptin 15ND2

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