Sclareol
Sclareol
CAS: 515-03-7
Molecular Formula: C20H36O2
Sclareol - Names and Identifiers
Sclareol - Physico-chemical Properties
| Molecular Formula | C20H36O2 |
| Molar Mass | 308.51 |
| Density | 0.954±0.06 g/cm3(Predicted) |
| Melting Point | 95-100 °C (lit.) |
| Boling Point | 218-220 °C/19 mmHg (lit.) |
| Specific Rotation(α) | -13 º (c=4, in carbon tetrachloride) |
| Flash Point | 169.1°C |
| JECFA Number | 2029 |
| Solubility | Soluble in 95% ethanol and oils |
| Vapor Presure | 5.36E-08mmHg at 25°C |
| Appearance | White crystalline powder |
| Color | White to Off-White |
| BRN | 2054148 |
| pKa | 14.49±0.29(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.489 |
| MDL | MFCD00869558 |
| Physical and Chemical Properties | white crystals. Boiling point> 340 ℃, melting point 101-103 ℃, specific optical rotation -11 °, soluble in 95% ethanol and oil. Very faint amber aroma. Long-lasting aroma. |
| Use | For flavor, spices, cigarettes, cosmetics, health food, food additives |
Sclareol - Risk and Safety
| WGK Germany | 2 |
| RTECS | QK0301900 |
| HS Code | 29061990 |
Sclareol - Reference
| Reference Show more | 1. [IF=5.882] Xue Han et al."Sclareol ameliorates hyperglycemia-induced renal injury through inhibiting the MAPK/NF-κB signaling pathway."PHYTOTHERAPY RESEARCH |
Sclareol - Reference Information
| FEMA | 4502 | (-)-SCLAREOL |
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| overview | perilla alcohol (English Sclareol) is a white crystalline powder extracted from the stems and leaves of the natural Labiatae plant-Salvia SclareL. It has a melting point of 95-105 ℃ and a weak amber (dragon saliva) aroma. The aroma is delicate, diffuse and durable, which can give the essence a vivid and harmonious aroma, it is an ideal raw material for the synthesis of ambergris products. It is mainly used for the synthesis of natural ambergris substitutes such as vanilla lactone and ambergris ether. A smaller amount is also used for the preparation of flavors. It is used in the field of medicine for antibacterial, anti-inflammatory, choleretic and anti-cancer. In the field of pesticides, it is used to control crop rust, powdery mildew, kill insects, mediate plant growth activity and plant defense function activity. |
| properties | perilla alcohol has an aroma similar to ambergris, with a lasting and delicate aroma, and is an ideal raw material for synthesizing ambergris products. Extraction and processing of products with petroleum ether. The degradation of the hard tail alcohol in tobacco produces cyclic ethers that reduce 2 carbon atoms, 1,2, 5,9-tetramethyl-2-hydroxydecalin, 2-hydroxybutanone, and vanilla lactone., Lactone is reduced to form another very important substance, Jianglonghuxiang ether. |
| perilla | also known as southern European salvia miltiorrhiza and rosette sage. A biennial or perennial herb of the genus Salvia in the Lamiaceae family, about 1~2 meters high, the lower stem is lignified, upright, branched, and the whole plant is short tomentose. Single leaf opposite, ovoid or oblong. Inflorescences, flowers bisexual, pink or light purple or white, bracts broadly ovate, corolla snow cyan. Nutlets ovoid, gray-brown, smooth. Flowering period is from June to July. Seed maturity period 7 months. Happy light, cold-resistant, drought-resistant, barren-resistant, afraid of waterlogging. The seedlings are not shade tolerant. Native to southern Europe. Introduced in the 1950s in my country, it is currently distributed in Shaanxi, Hebei, Henan, Zhejiang and other provinces. In particular, perilla, which grows in shallow mountainous areas in northern Shaanxi, has a high ester content and pure aroma due to the large temperature difference between day and night in this area, temperature, humidity and altitude are especially suitable for the growth of herbal medicines. Wide adaptability, cold tolerance, drought tolerance, barren tolerance. Seedlings are afraid of waterlogging and can withstand -8 ℃ to -10 ℃, while adult plants can withstand low temperatures around -25 ℃. Sufficient water is required in the early stage of flowering to achieve high yield. Seed reproduction should be sown in autumn. Fragrant raw materials can be collected in mid-to-late June of the following year. Parks and courtyards should be sown in spring. |
| synthesis method | perilla alcohol is extracted from the residue after water vapor extraction of perilla frutescens (Salvia Sclarea L.) with solvent extraction. Or the perilla plant is extracted with a solvent, after steam distillation, the volatile oil of the perilla is separated, and the residue is dewaxed and recrystallized to obtain the product (the solvent is: petroleum ether, trichloroethylene, etc.; the mixed solvent is methanol or petroleum ether solution of ethanol or ethylene glycol). |
| use | is mainly used to synthesize spices with ambergris-amber fragrance. when its fragrance fixing performance is directly used for fragrance blending, it is more suitable for perfume essence. Used for flavors, spices, cigarettes, cosmetics, health foods, food additives, etc. |
| production method | 1. perilla alcohol is extracted from the residue after water vapor extraction from Salvia Sclarea L. with solvent. Or the perilla plant is extracted with a solvent, after steam distillation, the volatile oil of the perilla is separated, and the residue is dewaxed and recrystallized to obtain the product (the solvent is: petroleum ether, trichloroethylene, etc.; the mixed solvent is methanol or petroleum ether solution of ethanol or ethylene glycol). 2. Tobacco: 9. |
Last Update：2024-04-09 20:52:54
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