Scutellarin
Scutellarin
CAS: 27740-01-8
Molecular Formula: C21H18O12
Scutellarin - Names and Identifiers
| Name | Scutellarin |
| Synonyms | Scutellarin Scutellarein 7-glucuronide Scutellarein 4'-methyl ether 7-glucuronide (4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-7-yl β-D-Glucopyranosiduronicacid,5,6-dihydroxy-2- 4',5,6-Trihydroxy-7-[(β-D-glucopyranuronosyl)oxy]flavone 4',5,6-Trihydroxyflavon-7-yl β-D-glucopyranosiduronic acid 7-(beta-D-Glucopyranuronosyloxy)-5,6-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 5,6-Dihydroxy-4-oxo-2-(4-hydroxyphenyl)-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid |
| CAS | 27740-01-8 |
| EINECS | 1806241-263-5 |
| InChI | InChI=1/C21H18O12/c22-8-3-1-7(2-4-8)10-5-9(23)13-11(31-10)6-12(14(24)15(13)25)32-21-18(28)16(26)17(27)19(33-21)20(29)30/h1-6,16-19,21-22,24-28H,(H,29,30)/t16-,17-,18+,19-,21+/m0/s1 |
Scutellarin - Physico-chemical Properties
| Molecular Formula | C21H18O12 |
| Molar Mass | 462.36 |
| Density | 1.810±0.06 g/cm3(Predicted) |
| Melting Point | 300～301℃ |
| Boling Point | 891.6±65.0 °C(Predicted) |
| Solubility | DMSO (Slightly), Methanol (Very Slightly, Sonicated) |
| Appearance | neat |
| Color | Light Yellow to Yellow |
| BRN | 71779 |
| pKa | 2.72±0.70(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Physical and Chemical Properties | Soluble in alkali, glacial acetic acid, pyridine, slightly soluble in general organic solvents, insoluble in water. It is suggested that DMSO be used to dissolve the leaves of the labiatae plant high scutellaria (Scutellaria altissima L.) |
Scutellarin - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 3 |
| HS Code | 29389090 |
Scutellarin - Nature
Open Data Verified Data
- baicalin is light yellow needle Crystal, soluble in dimethylformamide, pyridine, slightly soluble in hot acetic acid, insoluble in methanol, ethanol, acetone, almost insoluble in water, ether, benzene, chloroform, in the acid solubility is small, not easy to acid hydrolysis.
- dosage form 0. 28% Baicalin-flavone aqueous solution.
Last Update：2024-01-02 23:10:35
Scutellarin - Preparation Method
Open Data Verified Data
extract from the root of Scutellaria baicalensis Georgi.
Last Update：2022-01-01 11:18:48
Scutellarin - Use
Open Data Verified Data
The Botanical fungicide, 0. 28% baicalin and flavone, diluted 300~400 times, can be used to control Apple rot.
Last Update：2022-01-01 11:18:49
Scutellarin - Safety
Open Data Verified Data
low toxicity. Acute Oral and percutaneous LD50 of rats were greater than 5000mg/kg.
Last Update：2022-01-01 11:18:49
Scutellarin - Reference Information
| brief introduction | scutellarin, also known as breviscapine, is a flavonoid active ingredient isolated from the Compositae plant breviscapine, also known as breviscapine. it is insoluble in water. because it contains carboxyl groups, it can form salts with alkali or alkaline salts, and is easily soluble in water, and water insoluble substances are discarded. |
| properties | scutellarin is yellow needle-like crystal (in ethanol). The melting point is greater than 310% and darkens above 230 ℃. Optical rotation -14 (water),-139 (pyridine). Soluble in alkali, glacial acetic acid, pyridine, slightly soluble in general organic solvents, insoluble in water. |
| source | scutellaria baicalin comes from the leaves of the labiatae plant Gao scutellaria (Scutellaria altissima L.), the stems and leaves of scutellaria baicalensis [S.baicalensis Georgi], and the whole grass of S. Barbara D. Don, etc. |
| pharmacological effects | scutellarin has a variety of pharmacological effects, such as antioxidant, anti-inflammatory, anti-cancer, neuroprotective effects, inhibitory activity of protein kinase c, and reduction of cardiovascular and cerebrovascular ischemia reperfusion injury. |
| biological activity | breviscapine (Breviscapine, Breviscapin, Scutellarein-7-glucuronide) is the main active flavonoid extracted from the Chinese herbal medicine scutellaria baicalensis Scutellaria baicalensis and breviscapine Erigeron breviscapus, and has many pharmacological effects, such as antioxidant, anti-tumor, antiviral and anti-inflammatory activities. Scutellarin can down-regulate STAT3/Girdin/Akt signaling in HCC cells and inhibit RANKL-mediated MAPK and NF-κB signaling pathways in osteoclasts. |
| target | TargetValue STAT3 () Akt () NF-κB () |
| Target | Value |
| Chemical properties | Soluble in alkali, glacial acetic acid, pyridine, slightly soluble in general organic solvents, insoluble in water. It is recommended to use DMSO to dissolve the leaves of the labiatae plant high scutellaria (Scutellaria altissima L.) |
| use | used for content determination/identification/pharmacological experiments, etc. Pharmacological effects: It has the effects of reducing cerebrovascular resistance, improving cerebral blood circulation, increasing cerebral blood flow and anti-platelet aggregation. It is clinically used for the treatment of paralysis after cerebrovascular disease. |
Last Update：2024-04-09 21:54:55
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