Skepinone-L

Name	Skepinone-L
Synonyms	CS-1010 SKEPINONE Skepinone-L (R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann 3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one 2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one 5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-
CAS	1221485-83-1

Molecular Formula	C24H21F2NO4
Molar Mass	425.42
Density	1.384±0.06 g/cm3(Predicted)
Melting Point	130-134°C
Boling Point	629.0±55.0 °C(Predicted)
Solubility	DMSO (Slightly), Methanol (Slightly)
Appearance	Solid
Color	Light Yellow to Yellow
pKa	13.49±0.20(Predicted)
Storage Condition	2-8°C(protect from light)
In vitro study	Skepinone-L showed a concentration-dependent inhibition of HSP27 (Ser82) phosphorylation through the p38 MAPK pathway, the intracellular IC50 was about 25 nM, and it was also able to reduce TNF-α regulated by p38 MAPK, concentrations of IL-1β and IL-10, IC50 ranged from 30 to 50 nM. Skepinone-L (1 μm) abrogates the phosphorylation of the platelet p38 MAPK substrate Hsp27 activated by CRP, thrombin, or thromboxane A2 analog U-46619 stimulation, while also impairing platelet secretion and aggregation.
In vivo study	In Vivo, skepinone-L inhibited the Gal/LPS-induced release of TNF-α by 77%.

Last Update：2024-01-02 23:10:35

biological activity	Skepinone-L is a selective p38 MAPK inhibitor with an IC50 of 5 nM. Skepinone-L (CBS3830) is a selective p38 MAPK inhibitor with an IC50 of 5 nM.
Target	Value
p38α	5 nM

Last Update：2024-04-09 20:49:11

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CAS: 1221485-83-1
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QQ: 3008007409

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