Sl-1010
Sodium Hyaluronate
CAS: 9067-32-7
Molecular Formula: C14H22NNaO11
Sl-1010 - Names and Identifiers
| Name | Sodium Hyaluronate |
| Synonyms | Sph Si-4402 Sl-1010 HA Sodium cockscomb hyaluronic Hyaluronesodium Hyaluronate Sodium Sodium Hyaluronate Hyaluronic acid sodium salt |
| CAS | 9067-32-7 |
| EINECS | 618-620-0 |
| InChI | InChI=1/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1 |
| InChIKey | MAKUBRYLFHZREJ-JWBQXVCJSA-M |
Sl-1010 - Physico-chemical Properties
| Molecular Formula | C14H22NNaO11 |
| Molar Mass | 403.31 |
| Melting Point | >209°C (dec.) |
| Specific Rotation(α) | D25 -74° (c = 0.25 in water): Rapport et al., J. Am. Chem. Soc. 73, 2416 (1951) |
| Water Solubility | SOLUBLE |
| Solubility | H2O: 5mg/mL, clear, colorless |
| Appearance | White powder |
| Color | White to cream |
| Merck | 13,4776 |
| PH | pH(2g/l,25℃) : 5.5～7.5 |
| Storage Condition | -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Physical and Chemical Properties | Sodium hyaluronate, also called sodium hyaluronate, is a physiologically active substance widely present in the human body. It is a polymer quality linear mucopolysaccharide formed by polymerizing a disaccharide unit composed of glucuronic acid and acetylhexosamine. Its molecular weight is 1 million. It forms a thick viscoelastic solution in water with physiological pH and ionic strength. Its molecular morphology is variable, so it can also be passed with a thinner injection needle. If 10mg of this product is dissolved in 1 ml of normal saline, its viscosity is 200,000 times higher than that of aqueous humor or normal saline. |
| Use | Widely used in high-grade cosmetics industry, for dry eye syndrome |
Sl-1010 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 3 |
| RTECS | MT7250000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 39139000 |
| Toxicity | LD50 oral in rabbit: > 1gm/kg |
Sl-1010 - Reference
| Reference Show more | 1. Huang Weijiu Liu Chenglong Yu Yongmei et al. Effect of IgG and HA on corrosion behavior of TZNT alloy [J]. Rare metal materials and engineering, 2014, 43(006):1473-1478. 2. Lu Jiang, Jiang Xiang, Lu Feng, etc. Study of compound tea polyphenols Perfusion Solution on canine magnesium ammonium phosphate urinary stones in vitro [J]. Heilongjiang Journal of Animal Husbandry and Veterinary Medicine, 2018, 000(011):188-190. 3. Wang Xin, Xu Liping, Wang paili, et al. Purification of hyaluronic acid by anion exchange resin [J]. Food Research and Development, 2015(2):45-48. 4. Xu Liping, Wang paili, Wang Xin. Study on extraction conditions of hyaluronic acid from chicken crown [J]. Journal of Harbin University of Commerce (natural sciences), 2013, 29(004):421-425. 5. Chen, Qiaoling, yuan, Lin, Wang, et al. Optimization of extraction process and in vitro anti-inflammatory activity of crude polysaccharides from Atractylodes lancea [J]. Biomedical Engineering and clinical practice 2019(5):517-523. 6. Fan Ziyan, Zhao Ziyan, Zhao Xiang, etc. Purification and in vitro anti-inflammatory activity of total triterpenoids from bilberry [J]. Journal of Nanjing Forestry University: natural sciences edition, 2019, 043(004):132-138. 7. Zhang Hao, He Linyan, Wang Yan, et al. Study on the efficacy of aloe vera gel in post-Sun repair [J]. Fragrance and flavor cosmetics, 2019, No.174(03):65-71. 8. Guan Lingjun, Chen Xiaojun, Shen Dianjing, etc. Study on the preparation and moisturizing properties of Anoplophora glabrifolia cream [J]. Journal of Forestry and Environmental Sciences, 2020, 036(002):P.26-32. 9. Guo Rui, Li Yan, Wang Ping. Evaluation of antioxidant and anti-inflammatory activities of three Solanum nigrum fruit extracts in vitro [J]. Modern food science and technology, 2020, v.36;No.246(02):100-107. 10. Zhang Xuan, Li Xiangwei, Song Wenlong, ni Shilei, Qiu Yan, Liu Huimin, Li Na. Preparation and cytotoxicity of hyaluronic acid microspheres [J]. Journal of Practical Stomatology, 2020,36(06):954-958. 11. Zhao Yue. Design, preparation and biological application of biomimetic Intelligent Polymer hydrogel materials [D]. Jilin University, 2020. 12. Wei Qiyuan, oucan pure, Su Lianyu, Zuge Fang, Tang xioneng, Huang Renbin. Effect of total flavonoids of Acacia on hepatic fibrosis induced by CCl_4 in rats [J]. Liaoning Journal of Traditional Chinese Medicine, 2020,47(09):176-179 226-227. 13. Xiao Yin, Hongguo Xie, Ruixin Li, Shenggang Yan, Heng Yin, Regulating association strength between quaternary ammonium chitosan and sodium alginate via hydration, Carbohydrate Polymers, Volume 255, 2021, 117390, ISSN 0144-8617, https://doi.org/10.1016/j.ca 14. You, Baihao, et al. "Bilayered HA/CS/PEGDA hydrogel with good biocompatibility and self-healing property for potential application in osteochondral defect repair." Journal of materials science & technology 34.6 (2018): 1016-1025.https://doi.org/10.1016/j.j 15. Huan Lei, Chenhui Zhu, Daidi Fan, Optimization of human-like collagen composite polysaccharide hydrogel dressing preparation using response surface for burn repair, Carbohydrate Polymers, Volume 239, 2020, 116249, ISSN 0144-8617, https://doi.org/10.1016/j. 16. [IF=7.46] Lihua Chen et al."A novel label-free electrochemical immunosensor modified by glutathione and hyaluronic acid for the ultrasensitive and ultraselective detection of brucellosis in dilute serum."Sensor Actuat B- Chem. 2019 May;287:510 17. [IF=5.04] Baihao You et al."Bilayered HA/CS/PEGDA hydrogel with good biocompatibility and self-healing property for potential application in osteochondral defect repair."J Mater Sci Technol. 2018 Jun;34:1016 18. [IF=25.671] Xie Renjian et al."Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis."Nat Biomed Eng. 2021 Oct;5(10):1189-1201 19. [IF=20.722] Yang Liu et al."Chinese herb-crosslinked hydrogel bearing rBMSCs-laden polyzwitterion microgels: Self-adaptive manipulation of micromilieu and stemness maintenance for restoring infarcted myocardium."Nano Today. 2021 Dec;41:101306 20. [IF=9.229] Mengjie Chang et al."Suppression of Sunscreen Leakage in Water by Amyloid-like Protein Aggregates."Acs Appl Mater Inter. 2021;13(36):42451-42460 21. [IF=8.947] Zhao Yue et al."The Infliximab-Based Self-Healing Hydrogel Composite Scaffold Enhances Stem Cells Survival, Engraftment, and Function in Aiding Rheumatoid Arthritis Management."Acta Biomaterialia. 2020 Oct 05 22. [IF=8.947] Yue Zhao et al."Infliximab-based self-healing hydrogel composite scaffold enhances stem cell survival, engraftment, and function in rheumatoid arthritis treatment."Acta Biomater. 2021 Feb;121:653 23. [IF=7.367] Xuemin Liu et al."A Biomimetic Biphasic Osteochondral Scaffold with Layer‐Specific Release of Stem Cell Differentiation Inducers for the Reconstruction of Osteochondral Defects."Adv Healthc Mater. 2020 Dec;9(23):2000076 24. [IF=6.988] Chang-Sheng Wang et al."Understanding the Effect of Conformational Rigidity on Rheological Behavior and Formation of Polysaccharide-Based Hybrid Hydrogels."Biomacromolecules. 2021;22(9):4016-4026 25. [IF=4.979] Yang Lei et al."Hybrid Pericardium with VEGF-Loaded Hyaluronic Acid Hydrogel Coating to Improve the Biological Properties of Bioprosthetic Heart Valves."Macromol Biosci. 2019 Jun;19(6):1800390 26. [IF=4.749] Muyang Sun et al."Stepwise Cross-Linking of Fibroin and Hyaluronic for 3D Printing Flexible Scaffolds with Tunable Mechanical Properties."Acs Biomater Sci Eng. 2021;7(3):916-925 27. [IF=9.381] Yifeng Yu et al."Thiolated hyaluronic acid/silk fibroin dual-network hydrogel incorporated with bioglass nanoparticles for wound healing."Carbohyd Polym. 2022 Mar;:119334 28. [IF=9.078] Shuangli Zhu et al."Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg2 for diabetic wounds."Compos Part B- Eng. 2022 Feb;231:109569 29. [IF=6.331] Zihan Yi et al."The sodium hyaluronate microspheres fabricated by solution drying for transcatheter arterial embolization."Journal of Materials Chemistry B. 2022 Apr;: 30. [IF=6.331] Meilin Chen et al."Gellan gum modified hyaluronic acid hydrogel as viscosupplement with lubrication maintenance and enzymatic resistance."Journal of Materials Chemistry B. 2022 May ;: |
Sl-1010 - Reference Information
| sodium hyaluronate injection | sodium hyaluronate is a non-pharmaceutical neutral medium. Sodium hyaluronate injection is colorless and clear viscous liquid. Sodium hyaluronate is the main component of joint synovial fluid, is one of the components of cartilage matrix, in the joint cavity lubrication, can reduce the friction between tissues, at the same time play its elastic effect, buffer stress on the role of articular cartilage, play should have physiological functions. High molecular weight, high concentration and high viscoelasticity of sodium hyaluronate in the joint cavity can significantly improve the inflammatory reaction of the joint, enhance the viscosity and lubrication function of the joint fluid, and protect the articular cartilage, promote the healing and regeneration of articular cartilage, relieve pain and increase joint mobility. General Joint sodium hyaluronate dosage: temporomandibular joint with 1ml(10mg), shoulder joint with 2ml(20mg), hip, knee joint with 2.5 (25mg). It is mainly used for the treatment of degenerative osteoarthritis, chronic traumatic arthritis, rheumatic or rheumatoid arthritis, temporomandibular arthritis, aseptic necrosis of femoral head, etc. |
| pharmacological effects | sodium hyaluronate has the effect of promoting wound healing. Sodium hyaluronate can form a macromolecular network barrier on the surface of the eye tissue, prevent the inflammatory substances from entering the wound and the lesion area, and can significantly improve the viscosity and adhesion of the liquid medicine, the drug is concentrated on the corneal surface for a long time to achieve a long-lasting and potent effect. Transparent sodium can stabilize the tear film, prolong the break-up time of the tear film, and relieve the symptoms of ocular dryness. For keratitis, corneal ulcers, corneal damage or other chemical and physical factors caused by corneal burns. |
| pharmacodynamics | ① can protect corneal endothelium, epithelium, Iris and retina during surgery. ② instead of aqueous humor without loss, the anterior chamber depth can be maintained during surgery. (3) injection into the vitreous cavity may contribute to retinal reattachment due to compression. (4) in glaucoma surgery, it can enter the conjunctival filter to maintain the protrusion of the filter pillow. (5) it is helpful to separate tissue surface to reduce adhesion. |
| pharmacokinetics | sodium hyaluronate is a component of normal aqueous humor and vitreous, when injected into the anterior chamber or vitreous cavity, the normal concentration of each part can be temporarily increased. The Healon in the anterior chamber is gradually diluted by the new aqueous humor and excreted through the angle of the chamber through the scleral sinus; The Healon injected into the vitreous cavity gradually penetrates into the anterior chamber and is discharged through the aqueous humor dilution. In the experiments of monkey eyes, it was observed that the Healon injected into the vitreous cavity disappeared completely until 60~70 days. During this process, the concentration gradually decreases and the molecular size does not change. The Healon injected into the anterior chamber of the monkey disappeared within 1 week, similar to the clinical observation of the human eye. |
| Clinical application | for intraocular lens, cataract, glaucoma, corneal transplantation and retinal detachment surgery. |
| usage and dosage | is generally used for Intracameral injection, 0.5~0.75 each time. The use of Healon during intraocular lens implantation can maintain the depth of the anterior chamber during the whole operation, so that cataract extraction and intraocular lens implantation have a wider position to operate, the shape and orientation of the tissue in the anterior chamber can be maintained, so that the operation can be carried out smoothly and the early postoperative complications can be reduced. The application of healthon in corneal transplantation can protect corneal endothelium from its tissue damage. |
| adverse reactions | a small number of patients treated with Healon may have transient postoperative intraocular pressure elevation (25-30mmHg). 1 ~ 2d after the return to normal. This increase in intraocular pressure did not occur again if the Healon was diluted by an infusion of balanced saline in the anterior chamber at the end of the procedure. |
| attention | 1. Local eye drops may sometimes have irritation, foreign body sensation, pruritus, congestion, diffuse surface keratitis, etc. After ophthalmic surgery, the drug is left in the eye after mixing with blood or residual crystals, can be delayed absorption and inflammation, and the occurrence of a transient increase in intraocular pressure. Local injection may have a transient pain swelling or Fever feeling. Possible allergic symptoms are: sometimes may occur blepharitis, Eyelid dermatitis, individual patients can also appear rash, itching, rarely appear Shock, urticaria. 2. [contraindications] The drug allergy, leg vein and lymphatic reflux disorder patients, knee joint infection or inflammation patients, joint cavity infection in the acute phase of the joint cavity injection. The use of a large amount of the present drug is prohibited at the time of surgery for a diabetic patient without a crystal. 3. [caution] a history of drug allergy, liver dysfunction or a history of liver dysfunction, the elderly, children, pregnant and lactating women. 4. During the operation, the drug should be used to prevent excessive filling. After the operation, the residual liquid should be removed with balanced salt solution as needed, so that the intraocular pressure can be controlled to prevent the intraocular pressure from increasing. 5. When used for osteoarthritis, such as adding prednisolone, can relieve pain, is conducive to the recovery of joint function. 6. For ophthalmic surgery, intraocular pressure should be closely monitored during and after surgery. information on the physicochemical properties, pharmacological effects, pharmacokinetics, clinical application, usage and dosage of sodium hyaluronate, a commonly used drug in ophthalmology, was edited by Yao Yao of chemcialbook (2015-09-24). |
| consumption | ≤ 200 mg/day |
| applicable food category | infants, pregnant women and lactating women are not suitable for consumption. Scope of use and the recommended maximum amount of use: milk and dairy products (0.2g/kg), beverages (liquid beverage is less than or equal to 50 mL packaging 2.0g/kg, 51-500 mL packaging 0.20g/kg, solid beverages are converted by the volume of liquid after Brewing), alcohol (1.0g/kg), cocoa products, chocolate and chocolate products (including cocoa butter and chocolate products) and Candy (3.0g/kg), frozen drink (2.0g/kg). |
| approval date | 2021-01-07 |
| Announcement No. | |
| announcement title | National Health Commission on the fruiting body of cicada (artificial cultivation) such as 15 kinds of "three new food" announcement |
| Trait | white particles or powder |
| Sodium hyaluronate content , g/100g | ≥ 87.0 |
| Moisture , g/100g | ≤ 10.0 |
| pH | 6.0–8.0 |
| Ash , g/100g | ≤ 13.0 |
| Use | for dry eye syndrome. widely used in high-grade cosmetics industry, for dry eye syndrome |
| production method | is a salt of a carboxyl group of hyaluronic acid and a metal sodium ion. Hyaluronic acid is commonly found in animals and humans, such as skin, muscle, cartilage, brain, Crown, artery and vein wall, etc. Commonly used to extract raw materials are male comb, umbilical cord, bull's eye and so on. The method for preparing chicken comb as a raw material is as follows. 1. Extraction: fresh comb washed with acetone, dehydrated and crushed, soaked in distilled water and extracted for 24h, repeated 3 times, combined filtrate. 2. Deproteinization and precipitation: the extract was mixed with equal volume of chloroform and stirred for 3H. The aqueous phase was separated, and 2 times the amount of ethanol was added. 3. After enzymatic hydrolysis, complexation, dissociation, precipitation of high quality hyaluronic acid. The salt is then formed with the metal sodium ion. |
Last Update：2024-04-09 21:01:54
Sl-1010 - Intro
Sodium hyaluronate, also known as sodium hyaluronate, is a sodium salt of hyaluronic acid, and its dried product is a white granular powder with no odor. Sodium hyaluronate, as a glycosaminoglycan, exists in the extracellular stroma and cornea of various connective tissue cells in the human body. It is composed of D-glucuronic acid and N-acetyl-D-glucosamine, and can also be artificially extracted from the fermentation broth of Streptococcus equi or chicken coronavirus. Sodium hyaluronate and its solutions are often used in ophthalmic and orthopedic surgeries, providing support for surgical instruments and providing lubrication and cushioning for soft tissue joints. It is also widely used for cosmetic purposes and added to various cosmetics to enhance the skin's water retention effect
Last Update：2024-04-09 02:00:40
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