Molecular Formula | C10H11NaO3 |
Molar Mass | 202.18 |
Density | 1.24 g/cm3 (25 °C) |
Melting Point | 302°C |
Boling Point | 294.3°C at 760 mmHg |
Flash Point | 124.6°C |
Water Solubility | 1000g/L at 23℃ |
Solubility | Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
Vapor Presure | 0.001Pa at 20℃ |
Appearance | White powder |
Color | White to Off-White |
pKa | 8.46[at 20 ℃] |
PH | 9.5-10.5 (1g/l, H2O, 20°C) |
Storage Condition | Store at +15°C to +25°C. |
Stability | Hygroscopic |
Sensitive | Easily absorbing moisture |
MDL | MFCD00016477 |
Physical and Chemical Properties | White hygroscopic powder, soluble in water, alkaline. |
Use | Widely used in medicine, food, textile industry and other fields such as anti-corrosion of cosmetics, feed, daily industrial products |
Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
WGK Germany | 2 |
RTECS | DH2850000 |
HS Code | 2918 29 00 |
Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
This strain is refined by reacting propyl p-hydroxybenzoate in an aqueous solution of sodium hydroxide. The content of cl0h11nao3 should range from 98.0% to 102.0% based on the water content.
take 0, 10g of this product, add 0631 of water to dissolve, determine according to law (general rule),p H value should be 9. 5~10. 5.
take this product l. After adding 10ml of water to dissolve, check according to law (General rule 0901 and General Rule 0 9 0 2 ), the solution should be clarified; If the color is colored with brown red No. 3 Standard Colorimetric solution (General rule 0901 first method) comparison, not deeper.
take 2.0g of this product, add 40ml of water to dissolve, adjust the solution to Neutral with dilute nitric acid, dilute to 50ml with water, shake, filter, take the filtrate 5 .0 m l, checked according to law (General rule 0801), with standard gasified sodium solution 7. Compared with the control solution made of 0 M l, it should not be deeper (0.035%).
Take 2 5 m l of continued filtrate under chloride item, check according to law (General 0802), and standard potassium sulfate solution 2. Compared with the control solution made of 4m l, it should not be deeper (0. 024%).
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make 1.0 mg of the solution was used as a test solution; An appropriate amount was taken in a precise amount, and diluted with a mobile phase to prepare a solution containing 10 eq per 1 μl as a control solution. According to the chromatographic conditions under the content determination item, take 20M1 of the control solution and inject it into the liquid chromatograph to adjust the detection sensitivity so that the peak height of the main component chromatographic peak is about 20% of the full scale; then 20ul of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 4 times of the retention time of the main component peak. If there is a peak consistent with the retention time of the p-Hydroxybenzoic acid peak in the chromatogram of the test solution, the peak area of 1 .4 times should not be greater than 3 times the main peak area of the control solution (3 .0% ), the peak area of other single impurities should not be greater than 0 of the main peak area of the control solution. 5 times (0. 5% ), the sum of the peak areas of other impurities shall not be greater than the main peak area of the control solution (1 .0%).
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 5 .0%.
take 2.0g of this product and check it according to law (General Rule 0 8 2 1 Third method); If the test solution is colored and cannot be colored with thin caramel, take 4.0g of this product, add 10ml of sodium hydroxide test solution and 20ml of water to dissolve, then divide them into two equal parts, add water to make 25ml in tube B, add 5 drops of sodium sulfide test solution in tube A, shake well, pass through filter membrane (pore size 3pm). Filter, then add 2ml of standard lead solution in a tube, add water to make it 25m l, and then add 5 drops of sodium sulfide test solution in two tubes of a and B respectively, for comparison, heavy metals should not be more than 10 parts per million.
take this product l .O g, add lg of calcium hydroxide, mix, add 2ml of water, stir well, after drying, slowly burn to complete charring with small fire, and then burn in 500~6 0 0 1 to make it gray-white, cold, add hydrochloric acid 5M l and water 23ml, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (0.0002%).
measured by high performance liquid chromatography (General 0512).
pharmaceutical excipients, bacteriostatic agents.
sealed storage.
LogP | 0.27 at 23℃ |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
biological activity | Propylparaben sodium (Propyl parahydroxybenzoate sodium) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben sodium is commonly used in cosmetics, medicine and food. Propylparaben sodium disrupts follicular growth and steroidogenic functions by altering the cell cycle, apoptosis, and steroidogenic pathways. Propylparaben sodium also reduced sperm count and motility in rats. |
use | water-soluble preservatives are used in dairy products, pickles, beverages, fruit juices, jellies and cakes (the maximum amount is the same as propyl paraben). Water-soluble preservative. Widely used in the pharmaceutical industry. It is widely used in the anti-corrosion of medicine, food, textile industry and other fields such as cosmetics, feed, and daily industrial products |