Sodiumpropylester4-hydroxybenzoate
Sodium propyl p-hydroxybenzoate
CAS: 35285-69-9
Molecular Formula: C10H11NaO3
Sodiumpropylester4-hydroxybenzoate - Names and Identifiers
Sodiumpropylester4-hydroxybenzoate - Physico-chemical Properties
| Molecular Formula | C10H11NaO3 |
| Molar Mass | 202.18 |
| Density | 1.24 g/cm3 (25 °C) |
| Melting Point | 302°C |
| Boling Point | 294.3°C at 760 mmHg |
| Flash Point | 124.6°C |
| Water Solubility | 1000g/L at 23℃ |
| Solubility | Freely soluble in water, sparingly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
| Vapor Presure | 0.001Pa at 20℃ |
| Appearance | White powder |
| Color | White to Off-White |
| pKa | 8.46[at 20 ℃] |
| PH | 9.5-10.5 (1g/l, H2O, 20°C) |
| Storage Condition | Store at +15°C to +25°C. |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| MDL | MFCD00016477 |
| Physical and Chemical Properties | White hygroscopic powder, soluble in water, alkaline. |
| Use | Widely used in medicine, food, textile industry and other fields such as anti-corrosion of cosmetics, feed, daily industrial products |
Sodiumpropylester4-hydroxybenzoate - Risk and Safety
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 2 |
| RTECS | DH2850000 |
| HS Code | 2918 29 00 |
| Toxicity | LD50 orally in Rabbit: > 5000 mg/kg |
Sodiumpropylester4-hydroxybenzoate - Standard
Authoritative Data Verified Data
This strain is refined by reacting propyl p-hydroxybenzoate in an aqueous solution of sodium hydroxide. The content of cl0h11nao3 should range from 98.0% to 102.0% based on the water content.
Last Update：2024-01-02 23:10:35
Sodiumpropylester4-hydroxybenzoate - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder.
- This product is soluble in water, slightly soluble in ethanol.
Last Update：2022-01-01 11:25:43
Sodiumpropylester4-hydroxybenzoate - Introduction
Easily soluble in water, slightly soluble in alcohol, insoluble in methylene chloride, alkaline.
Last Update：2022-10-16 17:24:50
Sodiumpropylester4-hydroxybenzoate - Differential diagnosis
Authoritative Data Verified Data
- take 1 0 m g of this product, put it in a test tube, add 1 0.6% sodium carbonate solution lm l, heat, boil for 30 seconds, and let it cool, add 0.1% 4-aminoantipyrine in Borate Buffer (pH 9. 0 )(take 0. 618% boric acid 0. lm o l/L potassium chloride solution 1000ml with 0. lm o l/L sodium hydroxide solution 420ml mixed to get) 5ml and 5. 3% potassium ferricyanide solution lm l, mixed well, the solution turned red.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- identification reaction of sodium salt of this product (General rule 0301).
Last Update：2022-01-01 11:25:44
Sodiumpropylester4-hydroxybenzoate - Exam
Authoritative Data Verified Data
alkalinity
take 0, 10g of this product, add 0631 of water to dissolve, determine according to law (general rule),p H value should be 9. 5~10. 5.
clarity and color of solution
take this product l. After adding 10ml of water to dissolve, check according to law (General rule 0901 and General Rule 0 9 0 2 ), the solution should be clarified; If the color is colored with brown red No. 3 Standard Colorimetric solution (General rule 0901 first method) comparison, not deeper.
chloride
take 2.0g of this product, add 40ml of water to dissolve, adjust the solution to Neutral with dilute nitric acid, dilute to 50ml with water, shake, filter, take the filtrate 5 .0 m l, checked according to law (General rule 0801), with standard gasified sodium solution 7. Compared with the control solution made of 0 M l, it should not be deeper (0.035%).
sulfate
Take 2 5 m l of continued filtrate under chloride item, check according to law (General 0802), and standard potassium sulfate solution 2. Compared with the control solution made of 4m l, it should not be deeper (0. 024%).
Related substances
take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make 1.0 mg of the solution was used as a test solution; An appropriate amount was taken in a precise amount, and diluted with a mobile phase to prepare a solution containing 10 eq per 1 μl as a control solution. According to the chromatographic conditions under the content determination item, take 20M1 of the control solution and inject it into the liquid chromatograph to adjust the detection sensitivity so that the peak height of the main component chromatographic peak is about 20% of the full scale; then 20ul of the test solution and the control solution are respectively injected into the liquid chromatograph, and the chromatogram is recorded to 4 times of the retention time of the main component peak. If there is a peak consistent with the retention time of the p-Hydroxybenzoic acid peak in the chromatogram of the test solution, the peak area of 1 .4 times should not be greater than 3 times the main peak area of the control solution (3 .0% ), the peak area of other single impurities should not be greater than 0 of the main peak area of the control solution. 5 times (0. 5% ), the sum of the peak areas of other impurities shall not be greater than the main peak area of the control solution (1 .0%).
moisture
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 5 .0%.
Heavy metals
take 2.0g of this product and check it according to law (General Rule 0 8 2 1 Third method); If the test solution is colored and cannot be colored with thin caramel, take 4.0g of this product, add 10ml of sodium hydroxide test solution and 20ml of water to dissolve, then divide them into two equal parts, add water to make 25ml in tube B, add 5 drops of sodium sulfide test solution in tube A, shake well, pass through filter membrane (pore size 3pm). Filter, then add 2ml of standard lead solution in a tube, add water to make it 25m l, and then add 5 drops of sodium sulfide test solution in two tubes of a and B respectively, for comparison, heavy metals should not be more than 10 parts per million.
arsenic salt
take this product l .O g, add lg of calcium hydroxide, mix, add 2ml of water, stir well, after drying, slowly burn to complete charring with small fire, and then burn in 500~6 0 0 1 to make it gray-white, cold, add hydrochloric acid 5M l and water 23ml, according to the law inspection (General Principles 0822 The first law), should comply with the provisions (0.0002%).
Last Update：2022-01-01 11:25:45
Sodiumpropylester4-hydroxybenzoate - Content determination
Authoritative Data Verified Data
measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system applicability test using eighteen alkyl silane bonded silica gel as filler; Methanol -1% glacial acetic acid (60 : 40) as mobile phase, the detection wavelength was 254nm. Sodium hydroxyphenyl propyl ester and p-Hydroxybenzoic acid were taken, and the flow was matched to make each lm l containing 0. lm g mixed solution, take 20m1 injection liquid chromatograph, record chromatogram, the separation degree of p-Hydroxybenzoic acid peak and hydroxyphenyl propyl ester peak should meet the requirements.
- determination of the appropriate amount of this product, precision weighing, plus mobile phase dissolution and quantitative dilution made per lm l containing sodium hydroxyphenyl propyl ester 0. lm g solution, the precise amount of 20M1 injected into the liquid chromatograph, record the chromatogram; Another appropriate amount of hydroxyphenyl propyl ester reference substance, the same method for determination. According to the external standard method, the peak area is calculated by multiplying the coefficient of 1 .1 2 2.
Last Update：2022-01-01 11:25:45
Sodiumpropylester4-hydroxybenzoate - Category
Authoritative Data Verified Data
pharmaceutical excipients, bacteriostatic agents.
Last Update：2022-01-01 11:25:45
Sodiumpropylester4-hydroxybenzoate - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 11:25:46
Sodiumpropylester4-hydroxybenzoate - Reference Information
| LogP | 0.27 at 23℃ |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| biological activity | Propylparaben sodium (Propyl parahydroxybenzoate sodium) is an antibacterial preservative that can be produced by plants and bacteria. Propylparaben sodium is commonly used in cosmetics, medicine and food. Propylparaben sodium disrupts follicular growth and steroidogenic functions by altering the cell cycle, apoptosis, and steroidogenic pathways. Propylparaben sodium also reduced sperm count and motility in rats. |
| use | water-soluble preservatives are used in dairy products, pickles, beverages, fruit juices, jellies and cakes (the maximum amount is the same as propyl paraben). Water-soluble preservative. Widely used in the pharmaceutical industry. It is widely used in the anti-corrosion of medicine, food, textile industry and other fields such as cosmetics, feed, and daily industrial products |
Last Update：2024-04-09 21:01:54
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