Sorbitan monooleate
Span-80
CAS: 1338-43-8
Molecular Formula: C24H44O6
Sorbitan monooleate - Names and Identifiers
| Name | Span-80 |
| Synonyms | Span-80 Span 80 ionets80 sorgen40 glycomulo armotanmo sorbons80 emsorb2500 EmulsifierS80 Emulsifier S80 Sorbitan oleate Sorbitan monooleate Arlacel 80Sorbitan Monooleate Sorbitan Monooleate (Span 80) Sorbitan (Z)-mono-9-octadecenoate polyoxyethylene(20) sorbitan monooleate 1,4-anhydro-6-O-[(9Z)-octadec-9-enoyl]-D-glucitol [2-[(2R,3S,4R)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxy-ethyl] (Z)-octadec-9-enoate [(2R)-2-[(2R,3R,4S)-3,4-dihydroxytetrahydrofuran-2-yl]-2-hydroxy-ethyl] octadec-9-enoate |
| CAS | 1338-43-8 |
| EINECS | 215-665-4 |
| InChI | InChI=1/C24H44O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h9-10,20-21,23-26,28H,2-8,11-19H2,1H3/t20-,21+,23+,24+/m0/s1 |
| InChIKey | MPZLHRXPRGLWEB-AAZCQSIUSA-N |
Sorbitan monooleate - Physico-chemical Properties
| Molecular Formula | C24H44O6 |
| Molar Mass | 428.6 |
| Density | 0.986 g/mL at 25 °C(lit.) |
| Melting Point | 10～12℃ |
| Boling Point | 463.43°C (rough estimate) |
| Flash Point | >230°F |
| Water Solubility | Soluble in ethanol at 50mg/mlMiscible with water, ethanol, isopropanol and ether. Insoluble in acetone. |
| Solubility | Soluble in ethanol, isopropanol, mineral oil, vegetable oil, insoluble in water and propylene glycol |
| Appearance | yellow to amber viscous oily liquid |
| Specific Gravity | 0.986 |
| Color | Yellow |
| Merck | 13,8796 |
| BRN | 8172514 |
| Storage Condition | Store below +30°C. |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
| Sensitive | Easily absorbing moisture |
| Refractive Index | n20/D 1.48(lit.) |
| MDL | MFCD00080948 |
| Physical and Chemical Properties | Density 0.986 refractive index 1.48 flash point> 110°C |
| Use | Used in emulsion explosives, oil, medicine, cosmetics, textile, paint, leather and other industries |
Sorbitan monooleate - Risk and Safety
| Safety Description | 24/25 - Avoid contact with skin and eyes. |
| WGK Germany | 1 |
| RTECS | WG2932400 |
| TSCA | Yes |
| HS Code | 34021300 |
| Toxicity | LD50 orally in Rabbit: > 39800 mg/kg |
Sorbitan monooleate - Upstream Downstream Industry
Sorbitan monooleate - Reference
| Reference Show more | 1. Li Tong, Zhao Na, Shi Yu, et al. Optimization of Vitamin C Nanoemulsion Prescription and Its Percutaneous Permeability [J]. Journal of Shenyang Pharmaceutical University, 2018(7). 2. [IF = 5.396] Boru Chen et al."Enhancement of the solubility and antioxidant capacity of α-linolenic acid using an oil in water microemulsion." Food Funct. 2017 Aug;8(8):2792-2802 3. [IF = 7.312] Man-Ke Zhang et al."Magnetic alginate/PVA hydrogel microspheres with selective adsorption performance for aromatic compounds." Sep Purif Technol. 2021 Dec;278:119547 4. [IF = 6.165] Xiaoxue Liu et al."The palm oil-based microemulsion: Fabrication, characterization and rheological properties." J Mol Liq. 2020 Mar;302:112527 5. [IF = 4.539] Xiao-Jun Feng et al."Polydopamine-anchored polyether on Fe3O4 as magnetic recyclable nanoparticle-demulsifiers." Colloid Surface A. 2021 May;617:126142 6. [IF = 4.329] Ming Chen et al."Polyacrylamide Microspheres-Derived Fe3C @ N-doped Carbon Nanospheres as Efficient Catalyst for Oxygen Reduction Reaction." Polymers-Basel. 2019 May;11(5):767 7. [IF = 6.609] Fulong Ying et al."The kinetic effects of hydrate anti-agglomerants/surfactants." Fuel. 2022 Jun;318:123566 8. [IF = 7.328] Xueqing Yang et al."Development of PVA-based microsphere as a potential embolization agent." Mat Sci Eng C- Mater. 2022 Jan;:112677 9. [IF = 5.875] Yutong Wang et al."Extra virgin oil-based phospholipid complex/self-microemulsion enhances oral absorption of salvianolic acid B through inhibition of catechol-O-methyltransferase-mediated metabolism." Int J Pharmaceut. 2022 Jan;611:121330 10. [IF = 4.508] Cheng-Hai Yan et al."Formulation and stability of silkworm pupae oil microemulsion." Sustainable Chemistry and Pharmacy. 2022 Jun;27:100702 11. [IF = 5.89] Chunying Feng et al."Simple One-Step and Rapid Patterning of PDMS Microfluidic Device Wettability for PDMS Shell Production." Frontiers in Bioengineering and Biotechnology. 2022; 10: 891213 |
Sorbitan monooleate - Nature
Open Data Verified Data
Amber viscous oil, insoluble in water. Soluble in general hot oil and organic solvents; With good emulsifying and dispersing power. It is a water-in-oil surfactant.
Last Update：2024-01-02 23:10:35
Sorbitan monooleate - Preparation Method
Open Data Verified Data
Sorbitan and oleic acid were esterified.
Last Update：2022-01-01 09:28:40
Sorbitan monooleate - Standard
Authoritative Data Verified Data
This product is Sorbitan and oleic acid to form a mixture of esters, sorbitol dehydration, in alkaline catalyst, and oleic acid esterification prepared; or from sorbitol and oleic acid in 180 to 280*0 under the direct esterification of the system.
Last Update：2024-01-02 23:10:35
Sorbitan monooleate - Trait
Authoritative Data Verified Data
- This product is light yellow to yellow oily liquid, with slight abnormal odor.
- This product is insoluble in water or propylene glycol.
acid value
The acid value of this product (General Rule 0 7 1 3) is not more than 8.
saponification value
The saponification value of this product (General Rule 0 7 1 3) is 1 4 5~1 6 0 (saponification time 1 hour).
hydroxyl value
The Hydroxyl value of this product (General Rule 0 H 3) is 1 9 0~2 1 5.
iodine value
The iodine value of this product (General Rule 0 7 1 3) is 6 2~7 6.
perchlorination value
The peroxide value of this product (General Rule 0 7 1 3) is not more than 1 0.
Last Update：2022-01-01 11:23:34
Sorbitan monooleate - Introduction
Nonionic surfactants. Water/oil emulsifier. Gas chromatography stationary solution (maximum service temperature 150 ℃, solvent methanol), separation and analysis of oxygen-containing compounds. Stabilizer.
Last Update：2022-10-16 17:13:27
Sorbitan monooleate - Use
Open Data Verified Data
used as emulsifier, thickener, dispersant and rust inhibitor. In the emulsion explosives, textile oil as emulsifier; Paint industry as dispersant; Petroleum products as rust inhibitor and solvent; Titanium dioxide as a stabilizer in the production. And widely used in medicine, food and cosmetics industry.
Last Update：2022-01-01 09:28:40
Sorbitan monooleate - Differential diagnosis
Authoritative Data Verified Data
take about 2g of this product, put it in a 250m l flask, add 100ml of ethanol and 3 . 5 g of potassium hydroxide, and mix well. Heat reflux for 2 hours, add about 100ml of water, transfer to a 250ml beaker while hot, evaporate on a water bath and continue to add water, continue to evaporate until no ethanol odor, finally heat 100ml of water, slowly Dropwise add sulfuric acid solution (1-2) While it is hot until the litmus paper is neutral, record the consumed volume, continue to Dropwise add sulfuric acid solution (1-2) (about 10% of the above consumed volume), the liquid in the lower layer was clarified by standing. Transfer the above solution to a 10%-ml separatory funnel, extract with n-hexane for 3 times, each time, discard the n-hexane layer, and take the aqueous layer solution to adjust the p H value to 7 with potassium hydroxide solution. 0, water bath evaporation to dryness, the residue (if necessary, the residue is triturated) plus anhydrous ethanol 150ml, stirred with a glass rod, boiled in a water bath for 3 minutes, the above solution was placed in a funnel covered with diatomaceous earth, filtered, the solution was evaporated to dryness, and the residue was dissolved with 2ml of methanol as a test solution, 4-desosorbide 25mg with sorbitol 2 5M g, add methanol lm l to dissolve, as a reference solution. According to the thin layer chromatography (General 0502) test, absorb the above two solutions each 2 ml, respectively point on the same-silica gel G thin layer plate, with acetone-glacial acetic acid (50: 1) for Development, spread out, take out, dry, spray sulfuric acid solution (1- 2) to just wet, immediately heat at 20C0C until the spots are clear, cool, immediately check, the position and color of the spots of the test solution should be the same as that of the control solution.
Last Update：2022-01-01 11:23:35
Sorbitan monooleate - Exam
Authoritative Data Verified Data
fatty acid composition
take this product O . l g, put in 25ml Erlenmeyer flask, add 0.2ml of 5m o l/L sodium hydroxide methanol solution, shake to dissolve, heat reflux for 30 minutes, add 2ml of 14% boron trifluoride methanol solution along the condenser, heat reflux for 30 minutes, add n-heptane 4 m l along the condenser tube, heat and reflux for 5 minutes, cool, add 10ml saturated gasification sodium solution, shake for 15 seconds, add saturated gasification sodium solution to the neck of the bottle, mix well, let stand and separate the layers, take 2ml of the upper layer, wash with water for three times, 2 m l each time, take the upper layer and dry it with anhydrous sodium sulfate, as the test solution f, the following appropriate amount of each fatty acid methyl ester reference substance was accurately weighed, and dissolved and diluted with n-heptane to prepare methyl myristate 0.5mg and methyl palmitate 1 per l of lm l. Omg, methyl palmitoleate 0.5mg: methyl stearate 0.5mg, methyl oleate 6. Omg, methyl linoleate 1. Omg, methyl linolenic acid 0.5M g of mixed control solution (1 ), take l.O m I, put in a 10ml measuring flask, dilute to the scale with n-heptane, shake, as a mixed control solution (2). According to the gas chromatography method (General rule 0521), the capillary column with polyethylene glycol as stationary liquid is used as the column, the initial temperature is 1 70V, and the temperature is raised to 230TC at the rate of 2 t per minute, the sample inlet temperature was 250 * C, the detector temperature was 250TC, and 1M1 of each of the mixed reference solution (1) and (2) was injected into the human gas chromatograph to record the chromatogram, the resolution of the fatty acid methyl ester peak of each component in the mixed control solution (1) was not less than 1 .8, the theoretical plate number according to the peak of oleic acid methyl ester is not less than 30 000, the signal to noise ratio of the minimum fatty acid methyl ester peak in the mixed reference solution (2) should be greater than 5. Take Test Solution 1 ^ 1, inject human gas chromatograph, calculate according to peak area normalization method, containing myristic acid is not more than 5 ,0%, Palmitic acid not more than 1 6 .0%, palmitoleic acid not more than 8.0%, stearic acid not more than 6 .0%, oleic acid is 65.0% ~ 8 8.0%, linoleic acid not more than 18.0%, linolenic acid not more than 4 .0%, other fatty acids not more than 4 .0%.
moisture
take this product, according to the determination of moisture (General rule 0832 first method 1), the water content shall not exceed 1 .0%.
ignition residue
The l.O g of this product shall be taken for inspection according to law (General rule 0841), and the remaining residue shall not exceed.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 11:23:35
Sorbitan monooleate - Category
Authoritative Data Verified Data
pharmaceutical excipients, emulsifiers and Defoamers.
Last Update：2022-01-01 11:23:36
Sorbitan monooleate - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 11:23:36
Sorbitan monooleate - Reference Information
| hydrophilic and hydrophilic balance value (HLB value) | 4.3 |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| introduction | Span -80 is a yellow oily liquid, easily soluble in water, ethanol, methanol or ethyl acetate, and extremely slightly soluble in mineral oil. It is a w/o type emulsifier, which has strong emulsification, dispersion and lubrication effects, and can be mixed with various surfactants, especially suitable for Tween-60, and the compound use effect is better. HLB value 4.7, melting point 52-57 ℃. |
| use | span 80 is mainly used as solubilizer or emulsifier for injection and oral liquid; Dispersant for capsules; Emulsifier and matrix for ointment; Substrate for suppository, etc. Used as an emulsifier in the food industry. As an emulsifier in the production of food and cosmetics; as a dispersant in the paint and coating industry; as a stabilizer in the production of titanium dioxide; as an insecticide, wetting agent, and emulsifier in the production of pesticides; as a cosolvent in petroleum products; It can also be used as an antirust agent for antirust oil. Lubricants and softeners for textiles and leather. this product is used as emulsifier, stabilizer, thickener and wetting agent in medicine, cosmetics and textile industry, as dispersant and emulsifier in oil field. used in emulsion explosives, petroleum, medicine, cosmetics, textile, paint, leather and other industries used as gas chromatography stationary liquid, also used as emulsifier used as W/O food emulsifier, used alone or mixed with Tween -60, Tween -80, Tween -65. Our country stipulates that it can be used for vegetable protein beverages, milk, hydrogenated vegetable oil, bread, cakes and milk sugar, with a maximum usage of 1.5 g/kg; The maximum usage in fruit juice (flavor) beverages is 0.05 g/kg. In addition, it can also be used for the preservation of vegetables and fruits (coating film), and it can be used appropriately according to production needs. Good oil-in-water emulsifier. Gas chromatography stationary solution (maximum service temperature 150 ℃, solvent methanol), separation and analysis of oxygen-containing compounds. Stabilizer. Thickeners for food, cosmetics and drugs. Fiber lubricants and softeners for the textile industry. Non-ionic surfactants can be used to form oil-in-water emulsions and can be combined with low HLB surfactants to form water-in-oil emulsions. |
| application | span -80 is used as emulsifier, solubilizer, stabilizer, softener, antistatic agent, etc. It is suitable for medicine, cosmetics, textile, paint and other industrial fields. 1. Used as an emulsifier in the food industry, used in the production of beverages, milk sugar, ice cream, bread, cakes, malt extract, margarine, chocolate, etc.; used as an antistatic agent for acrylic fiber in the textile industry, The components of soft oiling agent; used as emulsifier and stabilizer in food, pesticide, medicine, cosmetics, paint, and plastic industry; used as antifogging drops for PVC, EVA, PE and other films, the dosage in PVC is 1.5 ~ 1.8% and in EVA is 0.7 ~ 1%. 2. in medicine and makeup |
| identification test | the iodine value of fatty acid (oleic acid) obtained from content analysis should be between 80 and 100. Iodine value was determined by OT-27 method. |
| content analysis | is the same as the content method in "sorbitan monolaurate (10042). |
| toxicity | ADl 0~25 mg/kg(FA0/WHO,1994). |
| usage limit | GB 2760-2001(g/kg): fruit and vegetable preservation (coating) GMF'; Juice (flavor) beverage 0.05; Vegetable protein beverage, milk, bread, hydrogenated vegetable oil, cake, milk sugar, 1.5. |
| production method | see sorbitol anhydride monostearate (10003) add 70% sorbitol to a stainless steel reaction kettle, add 0.6% mass water loss catalyst (phosphoric acid or p-toluenesulfonic acid), alcohol: acid = 1:(1.5~1.7)(molar ratio), raise the temperature to below 150 ℃, and lose water for 3 hours; then, oleic acid preheated to 90% and esterification catalyst (KOH or NaOH) of 0.3% mass are added into sorbitol, and the temperature is raised to 210 ℃ for 4~5h under the condition of nitrogen filling. When the acid value is less than 8mg KOH/g, the reaction is over. After standing, cooling and filtering, the product is obtained. put 88 kg sorbitol into the reaction kettle, dehydrate under reduced pressure, after dehydration, press 130 kg of refined oleic acid and appropriate amount of sodium hydroxide (as catalyst). Stirring, vacuumizing, slowly heating, reaction at 200~210 ℃ for 6 h. The acid value is measured by sampling. When the acid value is 6~7, the esterification reaction is completed. Cooling and cooling, standing for 24 h, standing after the upper and lower layers, the lower layer is black jelly, separated and discarded. Put the upper clarification hydraulic pressure into the decolorization kettle, heat to about 65 ℃ to decolorize with activated carbon, and decolorize at 80~85 ℃ for 1 h. Filtration, the filtrate is dehydrated under vacuum for 5 h to obtain the finished product. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:11:58
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Raw Materials for Sorbitan monooleate