Sulfadiazine
Sulfadiazine
CAS: 68-35-9
Molecular Formula: C10H10N4O2S
Sulfadiazine - Names and Identifiers
| Name | Sulfadiazine |
| Synonyms | SD Eksadiazine Sulfadiazine Sulphadiazine Sulfadiazine,(S) Sulfadiazine zinc salt 4-amino-N-2-pyrimidinyl N1-(2-Pyrimidinyl)-sulfanilamide -AMino-N-2-pyriMidinylbenzenesulfonaMide 4-Amino-N-2-pyrimidinyl-benzenesulfonamide 4-azanyl-N-pyrimidin-2-yl-benzenesulfonamide 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N1-(Pyrimidin-2-yl)sulfanilamide |
| CAS | 68-35-9 |
| EINECS | 200-685-8 |
| InChI | InChI=1/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H-,12,13,14,15,16) |
Sulfadiazine - Physico-chemical Properties
| Molecular Formula | C10H10N4O2S |
| Molar Mass | 250.28 |
| Density | 1.3780 (rough estimate) |
| Melting Point | 253 °C (dec.) (lit.) |
| Boling Point | 512.6±52.0 °C(Predicted) |
| Water Solubility | 67.13mg/L(25 ºC) |
| Solubility | Almost insoluble in water, slightly soluble in ethanol or acetone, easily soluble in dilute hydrochloric acid, sodium hydroxide solution or ammonia solution |
| Appearance | powder or crystals(white to faint yellow, faint pink) |
| Color | white |
| Merck | 14,8903 |
| BRN | 6733588 |
| pKa | pKa 2.21(H2Ot = 25I = 0.5 (NaCl)) (Uncertain) |
| Storage Condition | 2-8°C |
| Sensitive | Sensitive to light |
| Refractive Index | 1.6440 (estimate) |
| MDL | MFCD00006065 |
| Physical and Chemical Properties | White or off-white crystals or powders. Melting point 252-256 °c. Almost insoluble in water, at 37 C, pH = 5.6 water solubility of 13mg/100ml,pH = 7.5 water solubility of 200mg/100ml. Slightly soluble in ethanol or acetone, soluble in dilute hydrochloric acid, sodium hydroxide solution or ammonia solution, odorless, tasteless, light gradient dark. |
| Use | Sulfonamides for the treatment of infections caused by hemolytic streptococci, Pneumonia cocci, meningococci, Neisseria gonorrhoeae, E. Coli |
Sulfadiazine - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R36/37/38 - Irritating to eyes, respiratory system and skin. R42/43 - May cause sensitization by inhalation and skin contact. R43 - May cause sensitization by skin contact R42 - May cause sensitization by inhalation |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | WP1925000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29335990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 oral in mouse: 1500mg/kg |
Sulfadiazine - Upstream Downstream Industry
| Raw Materials | N,N-Dimethylformamide Calcium carbide Diethylamine Sulphaguanidine Sodium methoxide Phosphorus trichloride thiamine Ethyl Alcohol |
Sulfadiazine - Reference
| Reference Show more | 1. Zhuang Bintao, Ma Yuanyuan, Xie Shichen, Peng Junjie, Liang panhong, Zhu Xingquan, Yang Xiaoye, He Junjun. Effect Analysis of monensin sodium, sulfadiazine and artemether against Toxoplasma gondii RH strain tachyzoites in vitro and in vivo [J]. Chinese veterinary science, 2020,50(05):624-630. 2. Li Zhongling, Zhang Hongyan, Fu Bo, etc. Study on fermentation conditions of butyric acid bacteria MYS66 [J]. China Brewing, 2018, 037(002):75-79. 3. Chi Xiang, Zhou Wenbing, Wu Lin, etc. Oxidation removal of three tetracyclines and three sulfonamides from biogas slurry by Fenton process [J]. Journal of Agricultural Environment Science, 2018, 37(11):100-104. 4. Chi Xiang, Jin Yue, Zhou Wenbing, et al. Oxidation removal of three tetracyclines and three sulfonamides from biogas slurry by ultrasound-Fenton process [J]. Journal of Environmental Sciences, 2019(7). 5. Kollinger, Kefei, niudejun, et al. Screening of sulfonamide sensitive strains by UV mutagenesis and its application in the detection of milk sulfonamide antibiotics [J]. Modern food science and technology, 2019, 35(5):296-303. 6. Jin Yue, Zhou Wenbing, Xiao Naidong, Cai Jianbo, Cai Huan, Wang shuofeng. Removal of three sulfonamide antibiotics from pig farm biogas slurry by BiFeO_3/H_2O_2 Fenton-like system [J]. Journal of Agricultural Resources and Environment, 2020,37(06):945-950. 7. [IF = 19.503] Cheng-Xin Chen et al."Non-covalent self-assembly synthesis of AQ2S@rGO nanocomposite for the degradation of sulfadiazine under solar irradiation: The indispensable effect of chloride."Appl Catal B- Environ. 2021 Dec;298:120495 8. [IF=7.514] Zi-Tao Zhong et al."Quantitative analysis of various targets based on aptamer and functionalized Fe3O4@graphene oxide in dairy products using pregnancy test strip and smartphone."Food Chem. 2021 Aug;352:129330 9. [IF=7.514] Yanan Cao et al."Rapid and selective extraction of norfloxacin from milk using magnetic molecular imprinting polymers nanoparticles."Food Chem. 2021 Aug;353:129464 10. [IF=6.057] Ruirui Xie et al."Lanthanide-functionalized metal-organic frameworks based ratiometric fluorescent sensor array for identification and determination of antibiotics."Talanta. 2021 Aug;231:122366 11. [IF=6.498] Jingyun Shi et al."Groundwater antibiotics and microplastics in a drinking-water source area northern China: Occurrence, spatial distribution, risk assessment, and correlation."Environ Res. 2022 Jul;210:112855 12. [IF=6.707] Nan Zhang et al."Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism."Appl Surf Sci. 2022 Apr;580:152285 13. [IF=4.223] Zhang Shiqiu et al."Enhanced removal of tetracycline via advanced oxidation of sodium persulfate and biochar adsorption."ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. 2022 May;:1-12 14. [IF=4.223] Zhang Shiqiu et al."Enhanced removal of tetracycline via advanced oxidation of sodium persulfate and biochar adsorption."ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. 2022 May;:1-12 15. [IF=4.759] Ji-Cheng Sun et al."Metal-organic framework modified carbon cloth for electric field enhanced thin film microextraction of sulfonamides in animal-derived food."JOURNAL OF CHROMATOGRAPHY A. 2022 May;:463120 16. [IF=4.759] Ji-Cheng Sun et al."Metal-organic framework modified carbon cloth for electric field enhanced thin film microextraction of sulfonamides in animal-derived food."JOURNAL OF CHROMATOGRAPHY A. 2022 May;:463120 17. [IF=5.833] Hu Wenyao et al."Flexible membrane composite based on sepiolite/chitosan/(silver nanoparticles) for enrichment and surface-enhanced Raman scattering determination of sulfamethoxazole in animal-derived food."MICROCHIMICA ACTA. 2022 May;189(5):1-12 |
Sulfadiazine - Introduction
Sulfadiazine is a sulfa antibiotic. Sulfadiazine eliminates the bacteria that cause infection by stopping the production of folic acid in bacterial cells, and is often used to treat urinary tract infections (UTI). The combination of sulfadiazine and pyrimethamine can be used to treat toxoplasmosis caused by Toxoplasma gondii.
Last Update：2022-10-16 17:27:53
Sulfadiazine - Compound sulfadiazine tablets
Authoritative Data Verified Data
This product contains sulfadiazine (C10H10N402S) and trimethoprim (C14H18N403) should be labeled with the amount of 90.0% ~ 110.0%.
prescription
sulfadiazine 400g
Trimethoprim 50g
Appropriate amount of excipients
Made into 1000 tablets
trait
This product is white tablet.
identification
- take an appropriate amount of fine powder of this product (about 0.lg of sulfadiazine), add 3ml of 0.4% sodium hydroxide solution and 3ml of water respectively, shake, filter, and take the filtrate and 0.5ml of copper sulfate test solution, that is, a cyan-green precipitate is generated, which changes to a purple-gray color after being placed.
- take an appropriate amount of fine powder of this product (about 25mg of trimethoprim), add 5ml of 0.4% sodium hydroxide solution, shake well, add 5ml of chloroform, shake extraction, and take 5ml of chloroform solution and dilute sulfuric acid, after shaking, 2 drops of iodine solution were added to form a brown precipitate in the dilute sulfuric acid layer.
- in the chromatogram recorded under the content determination item, the retention time of the two main peaks of the test solution should be consistent with the retention time of the corresponding two main peaks of the control solution.
- take an appropriate amount of fine powder of this product (about 50mg equivalent to sulfadiazine) to show the identification reaction of the first aromatic amine (General rule 0301).
examination
- dissolution of this product, according to the dissolution and release determination method (General 0931 second method), with 0.lmol/L hydrochloric acid solution 1000ml as the dissolution medium, the speed is 75 revolutions per minute, according to the law, after 60 minutes, take 10ml of the solution, filter, take 5ml of the continued filtrate with precision, in a 25ml measuring flask, dilute to the scale with mobile phase, shake well, and measure according to law according to the method under the item of determination containing child, and calculate the dissolution amount of sulfadiazine and trimethoprim in each tablet. The limit shall be 70% of the labeled amount and shall be in accordance with the regulations.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- determined by HPLC (General 0512) 9
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Acetonitrile-0.3% ammonium acetate solution (20:80) as mobile phase; The detection wavelength was 220nm. The number of theoretical plates shall not be less than 3000 calculated by trimethoprim peak, and the separation degree between sulfadiazine peak and trimethoprim peak shall meet the requirements.
- determination of 10 tablets of this product, precision weighing, fine grinding, precision weighing an appropriate amount (equivalent to sulfadiazine 80mg), put in a 100ml measuring flask, add 0.lmol/L sodium hydroxide solution 10ml, shake to dissolve sulfadiazine, then add the appropriate amount of methanol, shake to dissolve trimethoprim, dilute to the scale with methanol, shake, filter, 5ml of the continuous filtrate was accurately measured, placed in a 50ml measuring flask, diluted with mobile phase to the scale, and then shaken to be used as a sample solution. 20 u1 was accurately measured and human liquid chromatograph was injected, record the chromatogram; Take the sulfadiazine control product 80mg and trimethoprim control product 10mg separately, and put them into the same 100ml measuring flask, add 0.lmol/L sodium hydroxide solution 10ml, shake to dissolve sulfadiazine, then add the appropriate amount of methanol, shake to dissolve trimethoprim, dilute to the scale with methanol, shake well, take the appropriate amount with precision, then the mobile phase was quantitatively diluted to prepare a solution containing sulfadiazine 80ug and trimethoprim 10ug per lml, and the same method was used for determination. According to the external standard method to calculate the peak area, that is.
category
sulfonamides.
storage
light shielding, sealed storage.
Last Update：2022-01-01 14:18:34
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Raw Materials for Sulfadiazine