Sulfadimidine
Sulfamethazine Base
CAS: 57-68-1
Molecular Formula: C12H14N4O2S
Sulfadimidine - Names and Identifiers
| Name | Sulfamethazine Base |
| Synonyms | SM2 A-502 Azolmetazin SULFAMETAZINE Sulfadimidine Sulfamethazine Sulphadimidine Sulfamethazine Base Sulfadimidine solution sulfadimidine standard solution N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin 6-(4'-aminobenzol-sulfonamido)-2,4-dimethylpyrimidin 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin benzenesulfonamide,4-amino-N-(4,6-dimethyl-2-pyrimiidinyl)- Benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)- |
| CAS | 57-68-1 |
| EINECS | 200-346-4 |
| InChI | InChI=1/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16) |
Sulfadimidine - Physico-chemical Properties
| Molecular Formula | C12H14N4O2S |
| Molar Mass | 278.33 |
| Density | 1.2997 (rough estimate) |
| Melting Point | 197 °C |
| Boling Point | 294°C (rough estimate) |
| Water Solubility | 150mg/100mL (29 ºC) |
| Solubility | Almost insoluble in water (solubility: 29°C,150mg/100ml;37°C,192 mg/ml), dissolved in hot ethanol, insoluble in ether, easily soluble in dilute acid or dilute alkali solution. |
| Appearance | White or yellowish crystals or powders |
| Color | white to off-white |
| Merck | 14,8905 |
| BRN | 261304 |
| pKa | 7.4, 2.65(at 25℃) |
| Storage Condition | 2-8°C |
| Stability | Stable, but light sensitive. Incompatible with strong oxidizing agents. |
| Sensitive | Sensitive to light |
| Refractive Index | 1.6440 (estimate) |
| MDL | MFCD00006066 |
| Physical and Chemical Properties | Melting point 197-200°C water-soluble 150mg/100mL (29°C) |
| Use | Has inhibitory effect on hemolytic Streptococcus, Pneumonia coccus and meningitis and other bacteria |
Sulfadimidine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S23 - Do not breathe vapour. S24/25 - Avoid contact with skin and eyes. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. |
| WGK Germany | 2 |
| RTECS | WO9275000 |
| FLUKA BRAND F CODES | 10 |
| TSCA | Yes |
| HS Code | 29350090 |
| Toxicity | LD50 i.p. in mice: 1.06 g/kg (Bobranski) |
Sulfadimidine - Upstream Downstream Industry
Sulfadimidine - Reference
| Reference Show more | 1. Ma Haikuan, Han Xiaohong, Zhang Dihua, etc. Detection and Analysis of sulfonamides in fish by surface enhanced Raman spectroscopy [J]. Acta laser biology Sinica, 2014, 23(006):560-565. 2. Zhao Suhua, fan Hongjie. Serotype identification and drug resistance analysis of avian Escherichia coli in northern Anhui [J]. Journal of Animal Husbandry and Veterinary Medicine, 2017, 49(004):95-98. 3. Zhang Zheng, Li Pan-jie, Jiang Cai-yun, etc. Investigation of metals and antibiotics in municipal wastewater treatment process [J]. Journal of Nanjing Normal University (Engineering and Technology Edition), 2018, 018(002):86-92. 4. Kollinger, Kefei, niudejun, et al. Screening of sulfonamide sensitive strains by UV mutagenesis and its application in the detection of milk sulfonamide antibiotics [J]. Modern food science and technology, 2019, 35(5):296-303. 5. Liu Minfang, Cao mengrui, Li Rongxu, etc. Isolation, identification and drug sensitivity analysis of salmonella from waterfowl in some areas of Guangdong province [J]. Heilongjiang Journal of Animal Science and Veterinary Medicine, 2018(10). 6. Ning Yu, Chen Yu, Yan Zhiming. Sulfonamides in milk based on SNW-1 magnetic solid phase extraction [J]. Fujian Journal of Agricultural Sciences, 2020,35(10):1154-1161. 7. [IF = 19.503] Cheng-Xin Chen et al."Non-covalent self-assembly synthesis of AQ2S@rGO nanocomposite for the degradation of sulfadiazine under solar irradiation: The indispensable effect of chloride."Appl Catal B- Environ. 2021 Dec;298:120495 8. [IF=6.057] Song Hu et al."Reliable performance of aggregation-induced emission nanoparticle-based lateral flow assay for norfloxacin detection in nine types of animal-derived food."Talanta. 2020 Nov;219:121245 9. [IF=6.498] Jingyun Shi et al."Groundwater antibiotics and microplastics in a drinking-water source area, northern China: Occurrence, spatial distribution, risk assessment, and correlation."Environ Res. 2022 Jul;210:112855 10. [IF=4.821] Jin-Ye Lang et al."Preparation of boronate-modified larger mesoporous polymer microspheres with fumed silica nanoparticle and toluene as synergistic porogen for selective separation of sulfonamides."Microchem J. 2022 Apr;175:107193 11. [IF=6.707] Nan Zhang et al."Growth of MOF@COF on corncob as effective adsorbent for enhancing adsorption of sulfonamides and its mechanism."Appl Surf Sci. 2022 Apr;580:152285 12. [IF=7.963] Zikun Dong et al."Mechanism for biodegradation of sulfamethazine by Bacillus cereus H38."Sci Total Environ. 2022 Feb;809:152237 13. [IF=7.312] Yunyun Li et al."Mass transfer enhancement for rapid selective extraction of pharmaceuticals by enlarging the microporous on isostructural zeolitic imidazolate Framework-8."SEPARATION AND PURIFICATION TECHNOLOGY. 2022 Jul;293:121102 14. [IF=5.833] Hu Wenyao et al."Flexible membrane composite based on sepiolite/chitosan/(silver nanoparticles) for enrichment and surface-enhanced Raman scattering determination of sulfamethoxazole in animal-derived food."MICROCHIMICA ACTA. 2022 May;189(5):1-12 15. [IF=3.365] Guo-Ying Chen et al."Nanozyme based on ZIF-8 for the colorimetric detection of sulfonamides in cow milk."ANALYTICAL BIOCHEMISTRY. 2022 Sep;652:114748 |
Sulfadimidine - Nature
Open Data Verified Data
white or yellowish crystalline powder, odorless, slightly bitter taste. Melting point 176 °c. Very slightly soluble in ether and water, soluble in dilute acid or dilute alkali, light color gradually darkened.
Last Update：2024-01-02 23:10:35
Sulfadimidine - Preparation Method
Open Data Verified Data
with sulfamidine as raw material, obtained by cyclization with acetylacetone.
Last Update：2022-01-01 10:10:54
Sulfadimidine - Introduction
No smell, slightly bitter taste, the color gradually darkens when exposed to light.
Last Update：2022-10-16 17:26:30
Sulfadimidine - Use
Open Data Verified Data
used as an antibacterial agent for the prevention and treatment of Staphylococcus and hemolytic Streptococcus infection, suitable for the treatment of hemolytic Streptococcus, meningococcus, Pneumonia cocci and other infections. Mainly used for the treatment of fowl cholera, Fowl typhoid fever, chicken coccidiosis and so on.
Last Update：2022-01-01 10:10:55
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Raw Materials for Sulfadimidine