Sulfametoxipiridazine
sulfamethoxypyridazine
CAS: 80-35-3
Molecular Formula: C11H12N4O3S
Sulfametoxipiridazine - Names and Identifiers
| Name | sulfamethoxypyridazine |
| Synonyms | SMPZ Surirene Sulfozona Sultirene Sulfdurazin Sulfapyridazine Sulfametoxipiridazine sulfamethoxypyridazine Sulphamethoxypyridazine N1-(6-methoxypyridazin-3-yl)sulphanilamide Sulfanilamide, N1-(6-methoxy-3-pyridazinyl)- 4-amino-N-(6-methoxypyridazin-3-yl)benzenesulfonamide |
| CAS | 80-35-3 |
| EINECS | 201-272-5 |
| InChI | InChI=1/C11H12N4O3S/c1-18-11-7-6-10(13-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,15) |
Sulfametoxipiridazine - Physico-chemical Properties
| Molecular Formula | C11H12N4O3S |
| Molar Mass | 280.3 |
| Density | 1.3936 (rough estimate) |
| Melting Point | 182-183° |
| Boling Point | 564.9±60.0 °C(Predicted) |
| Flash Point | 295.4°C |
| Water Solubility | 579.5mg/L(25 ºC) |
| Solubility | Slightly soluble in acetone, very slightly soluble in ethanol, almost insoluble in water; soluble in dilute hydrochloric acid or alkaline hydroxide solution. |
| Vapor Presure | 8.8E-13mmHg at 25°C |
| Appearance | White or yellowish crystalline powder |
| Color | White to yellow |
| Merck | 14,8919 |
| BRN | 277076 |
| pKa | 6.7(at 25℃) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.6200 (estimate) |
| MDL | MFCD00057372 |
| Physical and Chemical Properties | White or yellowish crystalline powder; Odorless, bitter; Photochromic. The product is slightly soluble in acetone, very slightly soluble in ethanol, almost insoluble in water; Soluble in dilute hydrochloric acid or hydroxide alkali solution. The melting point of the product is 180~183 deg C (-177 deg C). |
| In vivo study | In preliminary studies in rats infected with Pneumocystis carvei, Sulfamethoxypyridazine was found to be very effective. Sulfamethoxypyridazine was also found to be as effective as sulfamethoxazole at a dose of 1 mg/kg body weight for the treatment of Pneumocystis carveyi-infected rats. In a mouse animal model, Sulfamethoxypyridazine was effective against Pneumocystis carinii, with ED50s of 0.06 mg/kg/day and 0.08 mg/kg/day derived from Giemsa and silver-plated staining scores, respectively. At a dose of 0.1 mg/kg/day or 0.3 mg/kg/day, Sulfamethoxypyridazine was significantly more effective against Pneumocystis carinii in a mouse animal model than 0.47 mg/kg/day. In goats, the biological half-life of Sulfamethoxypyridazine was 11.0 H and 13.7 H after im and SC administration, respectively. In goats, the systemic effectiveness of Sulfamethoxypyridazine was 68.6 and 58.7 after im and SC administration, respectively. In goats, the distribution and elimination half-lives of Sulfamethoxypyridazine were 6.28 hours for 0.1 hours, respectively. In goats, the apparent volume of distribution values and systemic clearance of Sulfamethoxypyridazine in the steady state were 0.39 ml/kg/min and 0.73 ml/kg/min, respectively. |
Sulfametoxipiridazine - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 2 |
| RTECS | WP0400000 |
| FLUKA BRAND F CODES | 10 |
| HS Code | 29350090 |
| Toxicity | LD50 orally in mice: 1750 mg/kg, (Seki) |
Sulfametoxipiridazine - Reference
| Reference Show more | 1. Wang Xuefeng, Wei Qingguang, fan Jiangping, et al. Sample pretreatment and detection conditions optimization of three sulfonamides and malachite green in aquatic products [J]. Journal of Food Safety and quality testing, 2018, 9(21):177-183. 2. Yan Shuai, Li Yongyu, Peng Yankun, Han Donghai, Liu Yachao. Design and experiment of automatic mixing control device for trace samples in Raman detection system [J]. Journal of Agricultural Machinery, 2021,52(01):324-332. |
Sulfametoxipiridazine - Introduction
No odor, bitter taste, discoloration in case of light. The frequency change is slightly soluble in acetone, slightly soluble in ethanol, and almost insoluble in the speech; it is easily soluble in dilute hydrochloric acid or alkali hydroxide solution.
Last Update：2022-10-16 17:28:58
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CAS: 80-35-3
Tel: 17505222756
Email: pules.cn@gmail.com
Mobile: +86-17551318830
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Multiple SpecificationsSpot supply
Product Name: Sulfamethoxypyridazine Visit Supplier Webpage Request for quotationCAS: 80-35-3
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