T-2毒素(镰刀菌属)
T-2 Toxin
CAS: 21259-20-1
Molecular Formula: C24H34O9
T-2毒素(镰刀菌属) - Names and Identifiers
T-2毒素(镰刀菌属) - Physico-chemical Properties
| Molecular Formula | C24H34O9 |
| Molar Mass | 466.53 |
| Density | 1.1942 (rough estimate) |
| Melting Point | 151.5℃ |
| Boling Point | 489.35°C (rough estimate) |
| Specific Rotation(α) | D26 +15° (c = 2.58 in ethanol) |
| Flash Point | 2°C |
| Appearance | powder |
| Color | white |
| Merck | 13,9872 |
| pKa | 13.24±0.70(Predicted) |
| Storage Condition | −20°C |
| Refractive Index | 1.6230 (estimate) |
T-2毒素(镰刀菌属) - Risk and Safety
| Risk Codes | R26/27/28 - Very toxic by inhalation, in contact with skin and if swallowed. R38 - Irritating to the skin R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S28 - After contact with skin, wash immediately with plenty of soap-suds. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S22 - Do not breathe dust. |
| UN IDs | UN 3462 6.1/PG 1 |
| WGK Germany | 3 |
| RTECS | YD0100000 |
| FLUKA BRAND F CODES | 10-21 |
| HS Code | 29329990 |
| Hazard Class | 6.1(a) |
| Packing Group | I |
| Toxicity | LD50 orally in female rats: 4.0 mg/kg (Marasas); LD50 (mg/kg) in mice: 5.2 i.p., 4.2 i.v.; in rats: 7.0 intragastric, 0.9-1.3 i.p., 0.9 i.v., 2.0 s.c.; in guinea pigs: 3.0-4.0 orally, 5.3 intragastric, 1.0 i.m., 1.0-2.0 i.v., 1.0-2.0 s.c.; in pigs: 5.0 orally, 3.0 i.v. (Yagen, Bailer) |
T-2毒素(镰刀菌属) - Reference
| Reference Show more | 1. [IF=5.373] Han Yan et al."A label-free electrochemical immunosensing platform based on PEI-rGO/Pt@Au NRs for rapid and sensitive detection of zearalenone."Bioelectrochemistry. 2022 Feb;143:107955 2. [IF=5.279] Wei Liu et al."Glycolysis and Reactive Oxygen Species Production Participate in T-2 Toxin-Stimulated Chicken Heterophil Extracellular Traps."J Agr Food Chem. 2021;XXXX(XXX):XXX-XXX |
T-2毒素(镰刀菌属) - Reference Information
| (IARC) carcinogen classification | 3 (Vol. 31, Sup 7) 1987 |
| Overview | T-2 toxin is one of the most toxic class A mycotoxins of the trichothecene family produced by Fusarium spp, it is a major toxin that contaminates corn and wheat field crops and stored grains. It is widely distributed in nature and covers the whole world. In World Health Organization (WHO), the Food and Agriculture Organization of the United Nations (FAQ) and the joint meeting held in Geneva in T-2, the toxin was equated with aflatoxin as one of the naturally occurring dangerous food contamination poisons. |
| properties | T-2 a toxin is a tetracyclic sesquiterpene compound, a polymer of three isoprene units. The chemical name is 4β-15-diacetoxy-3 α-hydroxy-8 α-(3-methylbutyryloxy) -12,13-epoxy-spor-9-ene, the molecular formula is C24H34O9. The toxin is stable in nature, and has strong heat resistance and ultraviolet resistance. Therefore, it is not easy to be inactivated by autoclaving during food production and processing. T-2 the toxin is sterilized at 200-210 °c for 30-40 minutes or soaked in NaClO-NaOH solution for at least 4 hours before inactivation. Some fungi and enzymes have the ability to alter and remove T-2 of toxin toxicity. Epoxy rings and double bonds are considered to be toxic groups. When the epoxy ring is opened, the toxic effect of the toxin basically disappears. |
| biological activity | T-2 Toxin (T-2 Mycotoxin) is a Mycotoxin produced by various sickle cell strains in feed and grain. The LD50 values for T-2 Toxin in small rats were 5.2 and 1.5 mg/kg BWa, respectively. T-2 Toxin (T-2 Mycotoxin) can be converted into a variety of metabolites. The typical metabolites of T-2 Toxin in animals are HT-2 toxin and T-2-triol, both of which are hydrolysis products. T-2 Toxin (T-2 Mycotoxin) is an inhibitor that inhibits the binding and protein synthesis of peptidyl transferases (60S ribosomal subunit), which inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids and increases the level of lipid peroxides in the liver. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in immune system, gastrointestinal tract and fetal tissues. |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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