T90101

T90101 - Names and Identifiers

Name	7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline
Synonyms	T90101 7-TRIFLUOROMETHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline Isoquinoline, 1,2,3,4-tetrahydro-7-(trifluoromethyl)-
CAS	199678-32-5
InChI	InChI=1/C10H10F3N/c11-10(12,13)9-2-1-7-3-4-14-6-8(7)5-9/h1-2,5,14H,3-4,6H2

T90101 - Physico-chemical Properties

Molecular Formula	C10H10F3N
Molar Mass	201.19
Density	1.213±0.06 g/cm3(Predicted)
Boling Point	228.9±35.0 °C(Predicted)
Flash Point	92.2°C
Vapor Presure	0.0716mmHg at 25°C
pKa	8.85±0.20(Predicted)
Refractive Index	1.475

T90101 - Introduction

7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline is an organic compound with the molecular formula C10H13F3N and the structural formula:

! [7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline](https://upload.wikimedia.org/wikipedia/commons/f/f8/7(trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline.svg)

Nature:
1. Appearance: 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline is a white or light yellow crystalline solid.
2. Melting Point: about 61-64 ℃.
3. Boiling point: About 155-156 ℃.
4. Density: about 1.228 g/cm.
5. Solubility: Soluble in alcohol, ether and ether solvent.

Use:
7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline is an organic synthetic compound that can be used to synthesize drugs, pesticides and other organic compounds. It can be used as an intermediate for antipsychotic and sedative drugs, as a hydrogenation reagent in organic synthesis, and as a catalyst for Heterocyclic Synthesis.

Method:
7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline can be prepared in a variety of ways. Common methods include:
1. Reacting trifluoromethyl butyl ether with aniline in the presence of aluminum chloride, and obtaining the target product through hydrogenation reaction;
2.1,2,3,4-tetrahydroisoquinoline is reacted with a trifluoromethylating reagent (such as trifluoromethyliodomethane) under basic conditions to yield 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline.

Safety Information:
When using or handling 7-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline, the following safety precautions should be observed:
1. Avoid inhalation, ingestion or contact with skin and eyes. Wear appropriate protective equipment such as gloves, goggles and protective clothing.
2. Maintain good ventilation conditions and avoid dust, smoke or vapor during operation.
3. Should be stored in a sealed container, placed in a cool, dry place, away from the fire and oxidant.
4. Waste shall be disposed of in accordance with relevant regulations. For large spills or accidents, appropriate clean-up and disposal measures should be taken, following standard operating procedures for chemical spills and waste disposal.

Last Update：2024-04-09 02:00:44