TEBUFENPYRAD
tebufenpyrad
CAS: 119168-77-3
Molecular Formula: C18H24ClN3O
TEBUFENPYRAD - Names and Identifiers
TEBUFENPYRAD - Physico-chemical Properties
| Molecular Formula | C18H24ClN3O |
| Molar Mass | 333.86 |
| Density | 1.1639 (rough estimate) |
| Melting Point | 61-62° |
| Boling Point | 468.4±45.0 °C(Predicted) |
| Flash Point | 237.1°C |
| Vapor Presure | 5.99E-09mmHg at 25°C |
| Appearance | neat |
| BRN | 8636471 |
| pKa | 13.19±0.46(Predicted) |
| Storage Condition | 0-6°C |
| Refractive Index | 1.5790 (estimate) |
| Physical and Chemical Properties | Melting Point: 61-62 vapor pressure: 0.010787mPa(40 ℃) Appearance: pure white crystal solubility: water 2.8mg/L(25 °c). Soluble in acetone, methanol, chloroform, acetonitrile, hexane and benzene and other organic solvents. |
| Use | It is an amide acaricide with excellent effects on various mites, Hemiptera and Homoptera |
TEBUFENPYRAD - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | 2588 |
| WGK Germany | 3 |
| RTECS | UQ6276400 |
| HS Code | 29331990 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in male, female rats (mg/kg): 595, 997 orally; >2000, >2000 dermally; LC50 in male rats (mg/m3): 2660 by inhalation (Inoue, Fukuchi) |
TEBUFENPYRAD - Reference
| Reference Show more | 1. [IF=7.086] Jiaxin Li et al."Effects of tebufenpyrad on freshwater systems dominated by Neocaridina palmata, Physa fontinalis, and Ceratophyllum demersum."CHEMOSPHERE. 2022 Sep;303:135118 |
TEBUFENPYRAD - Reference Information
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| acaricide | pyrazolamide is a fast and efficient new type of pyrazolamide acaricide, which was jointly developed by Mitsubishi Company of Japan and cyanamide company of the United States. It is quick and efficient for all kinds of mites and mites in the whole development period, and has a long duration of effect, with dicofol, phenylbutyltin, thiazone, etc., no cross-resistance, low toxicity, no systemic, but permeability, excellent selectivity to the target crop, the recommended dose (25 ~ 200mgAI/L) to most crops without drug damage. Pyramid is an obligate acaricide, which is an insect mitochondrial respiration inhibitor. Its mechanism of action is to inhibit electron transfer at site I. It does not act on biogenic amines or acetylcholine receptors in insects, nor does it act as a specific muscle or nerve agent. Its physiological and medicinal effects are rapid, and the effect on red spider eggs and adult mites is good. The effective period can reach more than 40 days, and it has a certain ability to withstand rain erosion. Low toxicity to humans, birds and bees and safe for crops. It is used to control harmful mites (including spider mites and whole claw mites) on apples, citrus, pears, peaches and almonds, spider mites of tea trees, various mites on vegetables (such as spider mites, red leaf mites and spider mites), spider mites and small claw mites on cotton. |
| usage | (1) fruit tree mites. The harmful mites (including spider mites and whole claw mites) on apples, pears, peaches and almonds were controlled at a dose of 50~200mg ai/L. (2) tea tree leaf mite. The dose of 33~200mg ai/L was used to control the leaf mites of tea plants. (3) vegetable mites. Various mites on vegetables, such as cotton leaf mites, red leaf mites and spider mites, were controlled at a dose of 25~200mg ai/L. (4) cotton mites. The dose of 250~750mg ai/L was used to control spider mites and small claw mites on cotton. (5) control citrus red spider. When the citrus red spider insect mouth rises and reaches the control density, apply the medicine, and spray evenly with 2000~3000 times of 10% pyridoxamine wettable powder (effective concentration 33~50mg/L), which has a good effect on citrus red spider mites and eggs, and can control the amount of harmful mites below the control index. (6) apple red spider. In the apple mite juvenile mite stage application is the best period, with 10% pyridoxamine wettable powder 2000~3000 times liquid (effective concentration of 33~50ml/L) uniform spray, on the apple mite mite all mite state have good control effect, on the active mite population control effect is obvious, and on apple spider mite overwintering eggs have a strong killing effect. |
| precautions | (1) the safe use of pesticides shall be observed, and the staff shall take personal safety protection measures when applying pesticides. (2) Store away from fire and heat sources, store in places where children and livestock cannot contact, and avoid direct sunlight. (3) It is toxic to fish and cannot be used in or near fish ponds; do not pollute the water area when cleaning equipment and disposing of waste liquid. (4) skin contact with pyridoxamine liquid medicine should be washed with a large amount of soap water; After the eyes are splashed with liquid medicine, they should be washed with water for more than 15 minutes and seek medical treatment quickly. (5) If poisoning occurs, you should be sent to the hospital for treatment immediately. |
| toxicity | acute oral LD50 in rats is 595~997 mg/kg, acute percutaneous LD50 is greater than 2000 mg/kg, and acute percutaneous LD50 in mice is 210~224 mg/kg. No irritation to rabbit skin. Acute inhalation of LC50 in rats was 3.01mg/L. The dose of subchronic toxicity test in rats was 100mg/kg, and that in mice was 300mg/kg. The non-effective dose of chronic toxicity test in rats is 1.0 mg/kg per day, and that in mice is 4.0 mg/kg per day. No mutagenic effect was found by Ames test and micronucleus test. Carp LC500.073mg/L, safe for bees. |
| use | high-efficiency and fast amide acaricides have unique chemical properties and modes of action, no cross resistance, and are quick-acting, efficient, long-lasting, low-toxicity, and no systemic (permeability) characteristics in the whole development process of various mites and mites. It also has a certain control effect on hemiptera pests such as aphids, leafhoppers, whiteflies, and is mainly used in cotton, fruit trees, vegetables, tea trees and other crops. The recommended concentration is 20~200mg/L. It is an amide acaricide, which is effective against various mites, Hemiptera and Homoptera pests, and is quick and efficient for mites in each growth period, and has a long lasting period. |
| production method | diethyl oxalate reacts with butanone to obtain ethyl propionyl pyruvate. ethanol or toluene is used as solvent, and the temperature is controlled at 0 ℃, which is conducive to the reaction. Then cycliding with hydrazine hydrate produces 3-ethyl-pyrazole -5-carboxylate, the reaction temperature is 15 ℃, the time is 2h, and the product is extracted with chloroform. Methylation with (CH3)2SO4, ethyl 3-ethyl -1-methyl pyrazole -5-carboxylic acid was obtained, chloroform was used as solvent, methylating agent was added dropwise at room temperature, and reacted at 40 ℃ for 2 hours. After thioyl chloride treatment, 4-chloro -3-ethyl -1-methyl pyrazole -5-carboxylic acid ethyl ester was prepared, and the temperature was heated and refluxed for 3 hours. NaOH was added for hydrolysis, heating and reflux for 5 hours, hydrochloric acid was added to adjust the pH value of 2~3, and solid was precipitated; then interact with SOCl2 to change the carboxyl group into an acyl chloride group; finally, it reacts with tert-butyl benzylamine in the presence of chloroform and triethylamine to obtain pyridoxamine. |
| category | pesticide |
| toxicity classification | poisoning |
| acute toxicity | oral administration-rat LD50: 595 mg/kg; Inhalation-rat LC50: 2660 mg/m3 |
| stimulation data | eye-rabbit 100 mg severe |
| flammability hazard characteristics | flammability; fire scene decomposes toxic hydrogen chloride, nitrogen oxide gas |
| storage and transportation characteristics | warehouse low temperature, ventilation, drying |
| fire extinguishing agent | water, carbon dioxide, foam, sand |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 21:54:55
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